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- W4286266677 endingPage "102861" @default.
- W4286266677 startingPage "102861" @default.
- W4286266677 abstract "Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ inflammatory damage and wide spectrum of autoantibodies. The autoantibodies, especially anti-dsDNA and anti-Sm autoantibodies are highly specific to SLE, and participate in the immune complex formation and inflammatory damage on multiple end-organs such as kidney, skin, and central nervous system (CNS). However, the underlying mechanisms of autoantibody-induced tissue damage and systemic inflammation are still not fully understood. Single cell analysis of autoreactive B cells and monoclonal antibody screening from patients with active SLE has improved our understanding on the origin of autoreactive B cells and the antigen targets of the pathogenic autoantibodies. B cell depletion therapies have been widely studied in the clinics, but the development of more specific therapies against the pathogenic B cell subset and autoantibodies with improved efficacy and safety still remain a big challenge. A more comprehensive autoantibody profiling combined with functional characterization of autoantibodies in diseases development will shed new insights on the etiology and pathogenesis of SLE and guide a specific treatment to individual SLE patients." @default.
- W4286266677 created "2022-07-21" @default.
- W4286266677 creator A5008764568 @default.
- W4286266677 creator A5034957547 @default.
- W4286266677 creator A5074674277 @default.
- W4286266677 date "2022-10-01" @default.
- W4286266677 modified "2023-10-11" @default.
- W4286266677 title "Autoantibodies in systemic lupus erythematosus: From immunopathology to therapeutic target" @default.
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