FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286268455> ?p ?o ?g. }

• W4286268455 endingPage "106045" @default.
• W4286268455 startingPage "106045" @default.
• W4286268455 abstract "The development of new antimicrobial agents is necessary to overcome the emerging antimicrobial resistance among infectious microbial pathogens. Herein, we successfully designed and synthesized quinolinequinones (QQs) with N-phenylpiperazine (QQ1-7) containing strong or weak EDG in the amino moiety by converting hydroxyquinoline (HQ) to the dichloroquinolinequinone (QQ) via chlorooxidation. We performed an extensive antimicrobial activity assessment of the QQs with N-phenylpiperazine (QQ1-7). Among the seven quinolinequinones (QQs) with N-phenylpiperazine tested, QQ3 and QQ4 were the most active molecules against Staphylococcus aureus (ATCC® 29213) with a MIC value of 1.22 μg/mL. In addition to this, while QQ4 was more than six (6) times more effective towards Enterococcus faecalis (ATCC® 29212), QQ3 was twenty-six (26) times more effective against same strain. Furthermore, the evaluation of antimicrobial activity indicated that six of seven synthesized QQs (QQ1-4, QQ6, and QQ7) exhibited superior biological potency, eight (8) times for five of them (QQ1-4 and QQ6) and two (2) times for QQ7, against Staphylococcus epidermidis (ATCC® 12228). Besides, all QQs except QQ5 displayed excellent antifungal activity against the fungi Candida albicans (ATCC® 10231). Among these, the two QQs (QQ3 and QQ4), which showed the lowest values against gram-positive bacterial strains (Staphylococcus aureus (ATCC® 29213), Staphylococcus epidermidis (ATCC® 12228), and Enterococcus faecalis (ATCC® 29212)) as well as fungal strains (Candida albicans (ATCC® 10231) and Candida parapsilosis (ATCC® 22019)), were further evaluated for their biofilm inhibition properties and their mode of action with in vitro potential antimicrobial activity against each of 20 clinically obtained resistant strains of gram-positive bacteria, and bactericidal activity using time-kill curve assay. In this study, we investigated the bactericidal effects of QQ3 against methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans strains. The findings of this study suggest that a significant bactericidal effect was seen with all tested 1 × MIC and 4 × MIC concentrations used within 24 h. Our findings present significant implications for an antimicrobial drug candidate for treating infections, especially those caused by clinically resistant MRSA isolates." @default.
• W4286268455 created "2022-07-21" @default.
• W4286268455 creator A5014836794 @default.
• W4286268455 creator A5019966710 @default.
• W4286268455 creator A5023372956 @default.
• W4286268455 creator A5046040400 @default.
• W4286268455 creator A5050883078 @default.
• W4286268455 creator A5052263481 @default.
• W4286268455 creator A5069330789 @default.
• W4286268455 creator A5070571759 @default.
• W4286268455 creator A5089056853 @default.
• W4286268455 date "2022-11-01" @default.
• W4286268455 modified "2023-10-02" @default.
• W4286268455 title "Discovery of quinolinequinones with N-phenylpiperazine by conversion of hydroxyquinoline as a new class of antimicrobial agents targeting resistant pathogenic microorganisms" @default.
• W4286268455 cites W1256502351 @default.
• W4286268455 cites W1988500745 @default.
• W4286268455 cites W2003835776 @default.
• W4286268455 cites W2019657105 @default.
• W4286268455 cites W2033969373 @default.
• W4286268455 cites W2063039714 @default.
• W4286268455 cites W2084724444 @default.
• W4286268455 cites W2086945873 @default.
• W4286268455 cites W2094807012 @default.
• W4286268455 cites W2097498294 @default.
• W4286268455 cites W2139783224 @default.
• W4286268455 cites W2145538332 @default.
• W4286268455 cites W2321554465 @default.
• W4286268455 cites W2409717177 @default.
• W4286268455 cites W2561010246 @default.
• W4286268455 cites W2569578041 @default.
• W4286268455 cites W2762475172 @default.
• W4286268455 cites W2765798932 @default.
• W4286268455 cites W2779140005 @default.
• W4286268455 cites W2791907327 @default.
• W4286268455 cites W2810554058 @default.
• W4286268455 cites W2895120513 @default.
• W4286268455 cites W2905340147 @default.
• W4286268455 cites W2944171090 @default.
• W4286268455 cites W2947056101 @default.
• W4286268455 cites W2952005855 @default.
• W4286268455 cites W2985795334 @default.
• W4286268455 cites W3029915622 @default.
• W4286268455 cites W3033081752 @default.
• W4286268455 cites W3040929658 @default.
• W4286268455 cites W3095661868 @default.
• W4286268455 cites W3120152238 @default.
• W4286268455 cites W3157313792 @default.
• W4286268455 cites W3159928340 @default.
• W4286268455 cites W3168432527 @default.
• W4286268455 cites W3178305855 @default.
• W4286268455 cites W3188973755 @default.
• W4286268455 cites W3196604517 @default.
• W4286268455 cites W3199965461 @default.
• W4286268455 cites W3206097689 @default.
• W4286268455 cites W3214309831 @default.
• W4286268455 cites W4213354399 @default.
• W4286268455 cites W4225371833 @default.
• W4286268455 doi "https://doi.org/10.1016/j.bioorg.2022.106045" @default.
• W4286268455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35921788" @default.
• W4286268455 hasPublicationYear "2022" @default.
• W4286268455 type Work @default.
• W4286268455 citedByCount "1" @default.
• W4286268455 countsByYear W42862684552023 @default.
• W4286268455 crossrefType "journal-article" @default.
• W4286268455 hasAuthorship W4286268455A5014836794 @default.
• W4286268455 hasAuthorship W4286268455A5019966710 @default.
• W4286268455 hasAuthorship W4286268455A5023372956 @default.
• W4286268455 hasAuthorship W4286268455A5046040400 @default.
• W4286268455 hasAuthorship W4286268455A5050883078 @default.
• W4286268455 hasAuthorship W4286268455A5052263481 @default.
• W4286268455 hasAuthorship W4286268455A5069330789 @default.
• W4286268455 hasAuthorship W4286268455A5070571759 @default.
• W4286268455 hasAuthorship W4286268455A5089056853 @default.
• W4286268455 hasConcept C145081991 @default.
• W4286268455 hasConcept C185592680 @default.
• W4286268455 hasConcept C2777949923 @default.
• W4286268455 hasConcept C2779489039 @default.
• W4286268455 hasConcept C2779895986 @default.
• W4286268455 hasConcept C2780917455 @default.
• W4286268455 hasConcept C4937899 @default.
• W4286268455 hasConcept C523546767 @default.
• W4286268455 hasConcept C54355233 @default.
• W4286268455 hasConcept C86803240 @default.
• W4286268455 hasConcept C89423630 @default.
• W4286268455 hasConceptScore W4286268455C145081991 @default.
• W4286268455 hasConceptScore W4286268455C185592680 @default.
• W4286268455 hasConceptScore W4286268455C2777949923 @default.
• W4286268455 hasConceptScore W4286268455C2779489039 @default.
• W4286268455 hasConceptScore W4286268455C2779895986 @default.
• W4286268455 hasConceptScore W4286268455C2780917455 @default.
• W4286268455 hasConceptScore W4286268455C4937899 @default.
• W4286268455 hasConceptScore W4286268455C523546767 @default.
• W4286268455 hasConceptScore W4286268455C54355233 @default.
• W4286268455 hasConceptScore W4286268455C86803240 @default.
• W4286268455 hasConceptScore W4286268455C89423630 @default.
• W4286268455 hasFunder F4320329283 @default.
• W4286268455 hasLocation W42862684551 @default.
• W4286268455 hasLocation W42862684552 @default.

• next