FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286276043> ?p ?o ?g. }

• W4286276043 endingPage "2469" @default.
• W4286276043 startingPage "2459" @default.
• W4286276043 abstract "The main purpose of this study was to develop and evaluate solid self-nanoemulsifying drug delivery systems (S-SNEDDs) of Atorvastatin/ Ezetimibe combination to combine the advantages of liquid SNEDDs with those of solid dosage forms and investigate the effect of solidification on both lipid lowering efficiency and the ability to enhance oral bioavailability of included poorly water soluble drugs. Spray dried solid powder was prepared using Aerosil 200 based on its high adsorption capacity and the ratio of liquid SNEDDs: Aerosil was (4:1) due to the smaller droplet size produced after reconstitution compared to other ratios. Surface morphology characteristics and drug-excipients interactions were evaluated via Scanning Electron Microscopy (SEM) and Fourier Transformed Infrared Spectroscopy (FTIR). Crystallinity nature affect drug dissolution so, it was determined by Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction (PXRD). Pharmacokinetic study investigated the ability of (S-SNEDDS) to improve oral bioavailability of included drugs while, pharmacodynamic study evaluate its efficiency to control serum cholesterol levels compared to pure drugs suspension and liquid SNEDDs. Solid spray dried powder showed very good flowability (3.41±0.23g/s) and rapid dispersion in water with maintaining the self-emulsifying efficiency of liquid formula. Physicochemical evaluation of powder showed spherical separated particles with no significant drug-excipients interactions and drugs are molecularly dispersed or in amorphous state that improve dissolution rate as proven by in-vitro release studies. Pharmacokinetic and pharmacodynamic studies proved that the solidification process had no remarkable effect on the efficiency of liquid formula to enhance oral bioavailability of incorporated drugs and control serum cholesterol level compared to pure drugs suspension. S-SNEDDS was proved as efficient candidate to improve oral bioavailability of Atorvastatin / Ezetimibe combination and control cholesterol serum levels." @default.
• W4286276043 created "2022-07-21" @default.
• W4286276043 creator A5001715635 @default.
• W4286276043 creator A5007603427 @default.
• W4286276043 creator A5034073006 @default.
• W4286276043 creator A5051739624 @default.
• W4286276043 date "2022-06-28" @default.
• W4286276043 modified "2023-09-23" @default.
• W4286276043 title "Impact on HDL and LDL of Hyperlipidemic Rat Models: Designed Solid Self-Nanoemulsifying Drug Delivery Systems with Atorvastatin and Ezetimibe combination" @default.
• W4286276043 cites W1679579176 @default.
• W4286276043 cites W1735246829 @default.
• W4286276043 cites W1810099862 @default.
• W4286276043 cites W1978636439 @default.
• W4286276043 cites W1981081691 @default.
• W4286276043 cites W1987507883 @default.
• W4286276043 cites W1991622083 @default.
• W4286276043 cites W1994691989 @default.
• W4286276043 cites W2008807497 @default.
• W4286276043 cites W2011891393 @default.
• W4286276043 cites W2022672711 @default.
• W4286276043 cites W2027096794 @default.
• W4286276043 cites W2027948774 @default.
• W4286276043 cites W2028001133 @default.
• W4286276043 cites W2033390870 @default.
• W4286276043 cites W2034095303 @default.
• W4286276043 cites W2040640911 @default.
• W4286276043 cites W2051541743 @default.
• W4286276043 cites W2056209601 @default.
• W4286276043 cites W2069983835 @default.
• W4286276043 cites W2074207007 @default.
• W4286276043 cites W2090485171 @default.
• W4286276043 cites W2115584863 @default.
• W4286276043 cites W2116136295 @default.
• W4286276043 cites W2151678885 @default.
• W4286276043 cites W2215836808 @default.
• W4286276043 cites W2223308790 @default.
• W4286276043 cites W2266613891 @default.
• W4286276043 cites W2271939593 @default.
• W4286276043 cites W2329224899 @default.
• W4286276043 cites W2410838866 @default.
• W4286276043 cites W2474660317 @default.
• W4286276043 cites W2510302043 @default.
• W4286276043 cites W2525752015 @default.
• W4286276043 cites W2613271837 @default.
• W4286276043 cites W2620579620 @default.
• W4286276043 cites W2732877934 @default.
• W4286276043 cites W2742595555 @default.
• W4286276043 cites W2769848125 @default.
• W4286276043 cites W2790498566 @default.
• W4286276043 cites W2794302209 @default.
• W4286276043 cites W2800189899 @default.
• W4286276043 cites W2805973280 @default.
• W4286276043 cites W2948961403 @default.
• W4286276043 cites W2972610603 @default.
• W4286276043 cites W3033587473 @default.
• W4286276043 cites W3036831731 @default.
• W4286276043 cites W3085532306 @default.
• W4286276043 cites W3128019583 @default.
• W4286276043 cites W4229786838 @default.
• W4286276043 doi "https://doi.org/10.52711/0974-360x.2022.00411" @default.
• W4286276043 hasPublicationYear "2022" @default.
• W4286276043 type Work @default.
• W4286276043 citedByCount "0" @default.
• W4286276043 crossrefType "journal-article" @default.
• W4286276043 hasAuthorship W4286276043A5001715635 @default.
• W4286276043 hasAuthorship W4286276043A5007603427 @default.
• W4286276043 hasAuthorship W4286276043A5034073006 @default.
• W4286276043 hasAuthorship W4286276043A5051739624 @default.
• W4286276043 hasConcept C101335993 @default.
• W4286276043 hasConcept C112705442 @default.
• W4286276043 hasConcept C121332964 @default.
• W4286276043 hasConcept C127413603 @default.
• W4286276043 hasConcept C15920480 @default.
• W4286276043 hasConcept C159985019 @default.
• W4286276043 hasConcept C160892712 @default.
• W4286276043 hasConcept C171250308 @default.
• W4286276043 hasConcept C181389837 @default.
• W4286276043 hasConcept C185592680 @default.
• W4286276043 hasConcept C192562407 @default.
• W4286276043 hasConcept C2778163477 @default.
• W4286276043 hasConcept C2778657065 @default.
• W4286276043 hasConcept C2779587474 @default.
• W4286276043 hasConcept C2779820397 @default.
• W4286276043 hasConcept C39519442 @default.
• W4286276043 hasConcept C42360764 @default.
• W4286276043 hasConcept C43617362 @default.
• W4286276043 hasConcept C46275449 @default.
• W4286276043 hasConcept C521977710 @default.
• W4286276043 hasConcept C55493867 @default.
• W4286276043 hasConcept C71924100 @default.
• W4286276043 hasConcept C97355855 @default.
• W4286276043 hasConcept C98274493 @default.
• W4286276043 hasConceptScore W4286276043C101335993 @default.
• W4286276043 hasConceptScore W4286276043C112705442 @default.
• W4286276043 hasConceptScore W4286276043C121332964 @default.
• W4286276043 hasConceptScore W4286276043C127413603 @default.
• W4286276043 hasConceptScore W4286276043C15920480 @default.
• W4286276043 hasConceptScore W4286276043C159985019 @default.

• next