Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286285282> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4286285282 abstract "Abstract Background Bladder cancer (BCa) is a malignant tumor that occurs in the bladder mucosa with high mortality. Circular RNAs (circRNAs), newly discovered noncoding RNAs, are associated with the occurrence and development of BCa. However, the effects of circRNAs in BCa have not been fully elucidated. Through the GEO (Gene Expression Omnibus) database, an abnormally expressed circular RNA, circHGS (hsa_circ_0004721), was first identified in BCa. In this study, we clarified the roles and potential mechanism of circHGS in BCa progression. Methods The level of circHGS in tissue and cell was assessed by qRT-PCR. The proliferation, migration and invasion of BCa cells were detected by CCK8, colony formation assay, wound-healing assay, and Transwell assays, respectively. The interaction between circHGS/VEGFC and miR-513a-5p was detected by dual luciferase and qRT-PCR. VEGFC protein level was detected by western blotting. Nude mouse xenograft model was used to clarify the role of circHGS in tumor growth in vivo . Results CircHGS, originating from the HGS gene, is upregulated in BCa tissues compared to normal tissues. Functionally, silencing of circHGS apparently suppressed BCa cell proliferation, migration and invasion, but circHGS overexpression showed the opposite result. In vivo experiments also suggested that knockdown of circHGS suppressed tumor growth. Mechanistically, circHGS functions as a sponge of miR-513a-5p to elevate VEGFC expression and activate the AKT/mTOR signaling pathway, ultimately promoting BCa progression. Conclusion Our findings indicated that circHGS promotes BCa progression via the miR-513a-5p/VEGFC/AKT/mTOR pathway and can be a promising therapeutic target of BCa." @default.
- W4286285282 created "2022-07-21" @default.
- W4286285282 creator A5026621177 @default.
- W4286285282 creator A5056970564 @default.
- W4286285282 creator A5057378727 @default.
- W4286285282 creator A5062690945 @default.
- W4286285282 creator A5079552709 @default.
- W4286285282 creator A5090583644 @default.
- W4286285282 date "2022-06-06" @default.
- W4286285282 modified "2023-09-23" @default.
- W4286285282 title "CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p/VEGFC axis and activating the AKT/mTOR signaling pathway" @default.
- W4286285282 doi "https://doi.org/10.21203/rs.3.rs-1689119/v1" @default.
- W4286285282 hasPublicationYear "2022" @default.
- W4286285282 type Work @default.
- W4286285282 citedByCount "0" @default.
- W4286285282 crossrefType "posted-content" @default.
- W4286285282 hasAuthorship W4286285282A5026621177 @default.
- W4286285282 hasAuthorship W4286285282A5056970564 @default.
- W4286285282 hasAuthorship W4286285282A5057378727 @default.
- W4286285282 hasAuthorship W4286285282A5062690945 @default.
- W4286285282 hasAuthorship W4286285282A5079552709 @default.
- W4286285282 hasAuthorship W4286285282A5090583644 @default.
- W4286285282 hasBestOaLocation W42862852821 @default.
- W4286285282 hasConcept C104317684 @default.
- W4286285282 hasConcept C119056186 @default.
- W4286285282 hasConcept C121608353 @default.
- W4286285282 hasConcept C127561419 @default.
- W4286285282 hasConcept C137738243 @default.
- W4286285282 hasConcept C1491633281 @default.
- W4286285282 hasConcept C173396325 @default.
- W4286285282 hasConcept C2779256057 @default.
- W4286285282 hasConcept C2780352672 @default.
- W4286285282 hasConcept C502942594 @default.
- W4286285282 hasConcept C54355233 @default.
- W4286285282 hasConcept C62112901 @default.
- W4286285282 hasConcept C62478195 @default.
- W4286285282 hasConcept C75217442 @default.
- W4286285282 hasConcept C86554907 @default.
- W4286285282 hasConcept C86803240 @default.
- W4286285282 hasConcept C95444343 @default.
- W4286285282 hasConceptScore W4286285282C104317684 @default.
- W4286285282 hasConceptScore W4286285282C119056186 @default.
- W4286285282 hasConceptScore W4286285282C121608353 @default.
- W4286285282 hasConceptScore W4286285282C127561419 @default.
- W4286285282 hasConceptScore W4286285282C137738243 @default.
- W4286285282 hasConceptScore W4286285282C1491633281 @default.
- W4286285282 hasConceptScore W4286285282C173396325 @default.
- W4286285282 hasConceptScore W4286285282C2779256057 @default.
- W4286285282 hasConceptScore W4286285282C2780352672 @default.
- W4286285282 hasConceptScore W4286285282C502942594 @default.
- W4286285282 hasConceptScore W4286285282C54355233 @default.
- W4286285282 hasConceptScore W4286285282C62112901 @default.
- W4286285282 hasConceptScore W4286285282C62478195 @default.
- W4286285282 hasConceptScore W4286285282C75217442 @default.
- W4286285282 hasConceptScore W4286285282C86554907 @default.
- W4286285282 hasConceptScore W4286285282C86803240 @default.
- W4286285282 hasConceptScore W4286285282C95444343 @default.
- W4286285282 hasLocation W42862852821 @default.
- W4286285282 hasOpenAccess W4286285282 @default.
- W4286285282 hasPrimaryLocation W42862852821 @default.
- W4286285282 hasRelatedWork W2801038214 @default.
- W4286285282 hasRelatedWork W2899204875 @default.
- W4286285282 hasRelatedWork W2948341381 @default.
- W4286285282 hasRelatedWork W3003597902 @default.
- W4286285282 hasRelatedWork W3005549771 @default.
- W4286285282 hasRelatedWork W3095403005 @default.
- W4286285282 hasRelatedWork W3217378727 @default.
- W4286285282 hasRelatedWork W4221012682 @default.
- W4286285282 hasRelatedWork W4281708914 @default.
- W4286285282 hasRelatedWork W4322723986 @default.
- W4286285282 isParatext "false" @default.
- W4286285282 isRetracted "false" @default.
- W4286285282 workType "article" @default.