FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286294893> ?p ?o ?g. }

• W4286294893 endingPage "e15030" @default.
• W4286294893 startingPage "e15030" @default.
• W4286294893 abstract "e15030 Background: Glioblastoma (GBM) is a short term life-threatening tumor, while lower-grade glioma (LGG) is a heterogeneous entity with longer survival due to its natural history. As few therapeutic options emerged in the past decades, innovation is lead by targetable molecular alterations such as FGFR, BRAF, NTRK... Therefore, molecular profiling access is critical for patients. Methods: We collected data from patients with GBM and LGG whose tumor sample underwent a molecular profiling with Foundation Medicine FMI testing trough clinical trials. Results: In the GBM group, we identified 26 patients, 18 males and 8 females. Medium age was 47. Median OS was 20.3 months (IC 95% 14.3-26.2). All patients were IDH wide type, one had a methylated MGMT with 13 unknown. Among them, we identified 126 alterations. The most frequent were: AKT (15.4%), BARD1 (15.4%), CDKN2A (28.5%), CDKN2B (42.3%), CKDN2C (7%), FAM (15.4%), kit (23.1%); MLL (30.7%), MTAP (loss 30.7%,) NF1 (30.7%), NOTCH (23.1%), PDGFRA (26.9%), RB1 (23.1%), tp53 (53.8%). PTEN alteration was present in 13 patients with 3 of them with 2 alterations. EGFR was found with more than 1 alteration in 5 patients: 10 amplifications, 2 rearrangements, 6 deletion and 14 other mutation. Finally, we identified also: 1 patient with a mutation of RET, 2 patients with non-actionable NTRK mutations, 3 MDM2 mutated patients. Two patients with an FGFR alteration underwent a treatment with Erdafitinib. In the LGG group we identified 11 patients, 7 females, with a medium age of 34 years old; median OS was 116.8 months/ 9.6 years (CI 95% 45.8-187.8). All patients were IDH mutated, 2 of them with a IDH2 alteration. 1p19q codeletion was detected in 3 patients with 5 unknown; 1 patent was found to have an MGMT methylation, 8 were not tested. A total of 81 mutations were identified with the most frequent: ATRX (54.5%), CDKN2A (18.1%), EGFR (36.4%) with 2 amplifications and 2 rearrangement; TERT (36.4%), tp53 (54.4%), TSC, NOTCH and PTEN loss in 27.7%. One of the patient has a TMB high (117) and he received immunotherapy in a clinical trial. Each of thr 36 patients had at least 6 mutations. We don’t know the percentage of patients who underwent a molecular profile without any alteration founded. Targetable drivers with a clinical relevance were: FGFR, NTRK, ALK, PTEN, MDM2, CDKN2A and CDKN2B. Conclusions: Molecular profiling gives an important data collection and therapeutic options on poor prognostic tumors such as GBM and LGG and may lead to explore new pathways of innovations." @default.
• W4286294893 created "2022-07-21" @default.
• W4286294893 creator A5015636598 @default.
• W4286294893 creator A5028963681 @default.
• W4286294893 creator A5070827373 @default.
• W4286294893 creator A5086705074 @default.
• W4286294893 creator A5090587408 @default.
• W4286294893 date "2022-06-01" @default.
• W4286294893 modified "2023-10-16" @default.
• W4286294893 title "Molecular alterations detected on patients with glioblastoma and low-grade glioma: Review of 37 cases." @default.
• W4286294893 doi "https://doi.org/10.1200/jco.2022.40.16_suppl.e15030" @default.
• W4286294893 hasPublicationYear "2022" @default.
• W4286294893 type Work @default.
• W4286294893 citedByCount "0" @default.
• W4286294893 crossrefType "journal-article" @default.
• W4286294893 hasAuthorship W4286294893A5015636598 @default.
• W4286294893 hasAuthorship W4286294893A5028963681 @default.
• W4286294893 hasAuthorship W4286294893A5070827373 @default.
• W4286294893 hasAuthorship W4286294893A5086705074 @default.
• W4286294893 hasAuthorship W4286294893A5090587408 @default.
• W4286294893 hasConcept C121608353 @default.
• W4286294893 hasConcept C126322002 @default.
• W4286294893 hasConcept C143998085 @default.
• W4286294893 hasConcept C16930146 @default.
• W4286294893 hasConcept C2775922572 @default.
• W4286294893 hasConcept C2776300330 @default.
• W4286294893 hasConcept C2777609662 @default.
• W4286294893 hasConcept C2778227246 @default.
• W4286294893 hasConcept C2780265364 @default.
• W4286294893 hasConcept C37307934 @default.
• W4286294893 hasConcept C502942594 @default.
• W4286294893 hasConcept C55493867 @default.
• W4286294893 hasConcept C62478195 @default.
• W4286294893 hasConcept C71924100 @default.
• W4286294893 hasConcept C86554907 @default.
• W4286294893 hasConcept C86803240 @default.
• W4286294893 hasConceptScore W4286294893C121608353 @default.
• W4286294893 hasConceptScore W4286294893C126322002 @default.
• W4286294893 hasConceptScore W4286294893C143998085 @default.
• W4286294893 hasConceptScore W4286294893C16930146 @default.
• W4286294893 hasConceptScore W4286294893C2775922572 @default.
• W4286294893 hasConceptScore W4286294893C2776300330 @default.
• W4286294893 hasConceptScore W4286294893C2777609662 @default.
• W4286294893 hasConceptScore W4286294893C2778227246 @default.
• W4286294893 hasConceptScore W4286294893C2780265364 @default.
• W4286294893 hasConceptScore W4286294893C37307934 @default.
• W4286294893 hasConceptScore W4286294893C502942594 @default.
• W4286294893 hasConceptScore W4286294893C55493867 @default.
• W4286294893 hasConceptScore W4286294893C62478195 @default.
• W4286294893 hasConceptScore W4286294893C71924100 @default.
• W4286294893 hasConceptScore W4286294893C86554907 @default.
• W4286294893 hasConceptScore W4286294893C86803240 @default.
• W4286294893 hasIssue "16_suppl" @default.
• W4286294893 hasLocation W42862948931 @default.
• W4286294893 hasOpenAccess W4286294893 @default.
• W4286294893 hasPrimaryLocation W42862948931 @default.
• W4286294893 hasRelatedWork W2126062426 @default.
• W4286294893 hasRelatedWork W2137361994 @default.
• W4286294893 hasRelatedWork W2155140015 @default.
• W4286294893 hasRelatedWork W2995185855 @default.
• W4286294893 hasRelatedWork W3197275894 @default.
• W4286294893 hasRelatedWork W3625525 @default.
• W4286294893 hasRelatedWork W4280622094 @default.
• W4286294893 hasRelatedWork W4286294893 @default.
• W4286294893 hasRelatedWork W4293497193 @default.
• W4286294893 hasRelatedWork W4295817416 @default.
• W4286294893 hasVolume "40" @default.
• W4286294893 isParatext "false" @default.
• W4286294893 isRetracted "false" @default.
• W4286294893 workType "article" @default.