Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286298037> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4286298037 endingPage "e21092" @default.
- W4286298037 startingPage "e21092" @default.
- W4286298037 abstract "e21092 Background: There is an emerging role of immunotherapy plus chemotherapy (ICC) in the front-line setting for the treatment of Non-Small Cell Lung Cancer (NSCLC) with reported improvement in overall survival (OS) and progression-free survival (PFS). In this review, we highlighted the efficacy and safety of combination regimens as a first-line therapy for NSCLC. Methods: A comprehensive literature search was done on PubMed, Cochrane, Embase, WOS, and Scopus until Dec-2021. The outcomes included progression free survival (PFS) and/or overall survival (OS) and treatment-related adverse events (TRAEs). The inverse variance method was used to generate hazard ratios (HR) with the corresponding 95% confidence intervals for the OS and PFS. Meanwhile, Mantle-Hazard variance was used to create risk ratios for TRAEs. Results: The total eleven randomized controlled trials (RCTs) involving 6,386 patients (pts) were included. 3,850 pts received ICC while 2536 pts received chemotherapy., Four studies each used atezolizumab and pembrolizumab while one study each used nivolumab, tislelizumab, and camrelizumab. The ICC group showed a significant improvement in both PFS (HR, 0.60; 95% CI, 0.54-0.66; p = < 0.00001) and OS (HR, 0.77; 95% CI, 0.68-0.87; p = < 0.0001). Atezolizumab combinations have better PFS and OS compared to the other combinations; HR 0.65 (0.59-0.71) and 0.82 (0.74-0.90), respectively. There was no statistically significant difference between the ICC and control groups regarding TRAEs (RR, 1.07; 95% CI, 0.99-1.16; p = 0.09). Further subgroup analysis is mentioned in the table. Conclusions: The ICC seems to be a promising front-line therapy for NSCLC with superior PFS and OS compared to chemotherapy alone and without significant increase in TRAES. [Table: see text]" @default.
- W4286298037 created "2022-07-21" @default.
- W4286298037 creator A5001755429 @default.
- W4286298037 creator A5007904679 @default.
- W4286298037 creator A5009647324 @default.
- W4286298037 creator A5035349031 @default.
- W4286298037 creator A5041321890 @default.
- W4286298037 creator A5043261871 @default.
- W4286298037 creator A5043907474 @default.
- W4286298037 creator A5074187192 @default.
- W4286298037 creator A5077073372 @default.
- W4286298037 creator A5078253569 @default.
- W4286298037 creator A5080354924 @default.
- W4286298037 creator A5080709675 @default.
- W4286298037 creator A5083375074 @default.
- W4286298037 date "2022-06-01" @default.
- W4286298037 modified "2023-10-16" @default.
- W4286298037 title "Immunotherapy plus chemotherapy versus chemotherapy alone as first-line treatment for non-small cell lung cancer: A systematic review and meta-analysis." @default.
- W4286298037 doi "https://doi.org/10.1200/jco.2022.40.16_suppl.e21092" @default.
- W4286298037 hasPublicationYear "2022" @default.
- W4286298037 type Work @default.
- W4286298037 citedByCount "0" @default.
- W4286298037 crossrefType "journal-article" @default.
- W4286298037 hasAuthorship W4286298037A5001755429 @default.
- W4286298037 hasAuthorship W4286298037A5007904679 @default.
- W4286298037 hasAuthorship W4286298037A5009647324 @default.
- W4286298037 hasAuthorship W4286298037A5035349031 @default.
- W4286298037 hasAuthorship W4286298037A5041321890 @default.
- W4286298037 hasAuthorship W4286298037A5043261871 @default.
- W4286298037 hasAuthorship W4286298037A5043907474 @default.
- W4286298037 hasAuthorship W4286298037A5074187192 @default.
- W4286298037 hasAuthorship W4286298037A5077073372 @default.
- W4286298037 hasAuthorship W4286298037A5078253569 @default.
- W4286298037 hasAuthorship W4286298037A5080354924 @default.
- W4286298037 hasAuthorship W4286298037A5080709675 @default.
- W4286298037 hasAuthorship W4286298037A5083375074 @default.
- W4286298037 hasConcept C121608353 @default.
- W4286298037 hasConcept C126322002 @default.
- W4286298037 hasConcept C143998085 @default.
- W4286298037 hasConcept C168563851 @default.
- W4286298037 hasConcept C197934379 @default.
- W4286298037 hasConcept C207103383 @default.
- W4286298037 hasConcept C2775949291 @default.
- W4286298037 hasConcept C2776256026 @default.
- W4286298037 hasConcept C2776694085 @default.
- W4286298037 hasConcept C2777701055 @default.
- W4286298037 hasConcept C2780030458 @default.
- W4286298037 hasConcept C2780057760 @default.
- W4286298037 hasConcept C2780739268 @default.
- W4286298037 hasConcept C44249647 @default.
- W4286298037 hasConcept C71924100 @default.
- W4286298037 hasConcept C95190672 @default.
- W4286298037 hasConceptScore W4286298037C121608353 @default.
- W4286298037 hasConceptScore W4286298037C126322002 @default.
- W4286298037 hasConceptScore W4286298037C143998085 @default.
- W4286298037 hasConceptScore W4286298037C168563851 @default.
- W4286298037 hasConceptScore W4286298037C197934379 @default.
- W4286298037 hasConceptScore W4286298037C207103383 @default.
- W4286298037 hasConceptScore W4286298037C2775949291 @default.
- W4286298037 hasConceptScore W4286298037C2776256026 @default.
- W4286298037 hasConceptScore W4286298037C2776694085 @default.
- W4286298037 hasConceptScore W4286298037C2777701055 @default.
- W4286298037 hasConceptScore W4286298037C2780030458 @default.
- W4286298037 hasConceptScore W4286298037C2780057760 @default.
- W4286298037 hasConceptScore W4286298037C2780739268 @default.
- W4286298037 hasConceptScore W4286298037C44249647 @default.
- W4286298037 hasConceptScore W4286298037C71924100 @default.
- W4286298037 hasConceptScore W4286298037C95190672 @default.
- W4286298037 hasIssue "16_suppl" @default.
- W4286298037 hasLocation W42862980371 @default.
- W4286298037 hasOpenAccess W4286298037 @default.
- W4286298037 hasPrimaryLocation W42862980371 @default.
- W4286298037 hasRelatedWork W2622595542 @default.
- W4286298037 hasRelatedWork W2947313540 @default.
- W4286298037 hasRelatedWork W2948845624 @default.
- W4286298037 hasRelatedWork W2981883049 @default.
- W4286298037 hasRelatedWork W2988525911 @default.
- W4286298037 hasRelatedWork W3215044659 @default.
- W4286298037 hasRelatedWork W4221037704 @default.
- W4286298037 hasRelatedWork W4313857758 @default.
- W4286298037 hasRelatedWork W4317566941 @default.
- W4286298037 hasRelatedWork W4322754005 @default.
- W4286298037 hasVolume "40" @default.
- W4286298037 isParatext "false" @default.
- W4286298037 isRetracted "false" @default.
- W4286298037 workType "article" @default.