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- W4286313897 abstract "Diffuse interstitial fibrosis (IF), which may be related to irreversibility of LV dysfunction (LVD), has been documented in animal models of PVC-induced cardiomyopathy (PIC) but has never been assessed in humans. In patients with suspected PIC, detection of IF with CMR-T1 mapping may improve risk stratification and predict response to catheter ablation We investigated the value of T1-mapping in identifying irreversibility of PIC after successful PVC elimination in patients with no evidence of macroscopic scar on late gadolinium enhancement (LGE) CMR imaging We studied 73 consecutive patients (42±17 years, 56% males, LVEF 37±8%) with frequent (mean burden 18%) PVC and LVD (LVEF<50%) who underwent successful PVC ablation and had either a significant improvement in LVD (LVEF ≥50% or improvement ≥10% from baseline) after treatment [Group 1, n=48 (65%)] or had no recovery of LVEF [Group 2, n=25 (34%)] after a minimum follow-up of 6 months after the procedure. Before ablation, all patients were extensively evaluated to rule out other causes of LVD and underwent CMR including LGE and native T1-mapping as an indicator of IF burden. There were no significant differences between the two groups in terms of age, gender, baseline LVEF, baseline PVC burden (22±13% vs. 27±14%; p=0.7) and PVC burden at follow-up (3±1% vs. 2±1%; p=0.2). Compared to Group 2, Group 1 patients had shorter PVC-QRS duration (136±13ms vs. 149±23ms, p<0.01) and lower values of native T1-time (948±36ms vs. 1082±52ms, p<0.01). After multivariable adjustment, T1-time (OR 0.96, 95% CI 0.95-0.98; p<0.01) remained an independent predictor of LVD reversibility In patients with suspected PIC undergoing catheter ablation, lack of LVEF recovery following successful PVC suppression is predicted by a higher burden of diffuse IF at baseline CMR. Whether IF is a consequence of frequent PVC or expression of an underlying structural heart disease remains to be elucidated" @default.
- W4286313897 created "2022-07-21" @default.
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- W4286313897 date "2022-05-01" @default.
- W4286313897 modified "2023-10-18" @default.
- W4286313897 title "PO-714-08 DIFFUSE INTERSTITIAL FIBROSIS DETECTED BY CMR-T1 MAPPING TO IDENTIFY IRREVERSIBILITY OF LV CARDIOMYOPATHY IN PATIENTS WITH FREQUENT PREMATURE VENTRICULAR COMPLEXES" @default.
- W4286313897 doi "https://doi.org/10.1016/j.hrthm.2022.03.1158" @default.
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