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- W4286356160 abstract "A chemical investigation on the herb Gerbera anandria (Linn) Sch-Bip led to the isolation and identification of six previously undescribed coumarin derivatives, named Gerberdriasins A-F (1-6). Structurally, their chemical structures and absolute configurations were determined by nuclear magnetic resonance (1D and 2D NMR), high resolution electrospray ionization mass spectroscopy (HR-ESI-MS), experimental and quantum mechanical nuclear magnetic resonance (QM-NMR) methods, Mosher's method and calculated electronic circular dichroism (ECD) experiments. The biological activity of the obtained compounds showed that they displayed significant neuroprotective effects against scopolamine-induced injury in PC12 cells at the concentrations 12.5, 25.0 and 50.0 nM. Further study demonstrated that 1 could inhibit cell apoptosis, decrease malondialdehyde (MDA) levels and increase superoxide dismutase (SOD) activity in scopolamine-treated PC12 cells." @default.
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- W4286356160 date "2022-01-01" @default.
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- W4286356160 title "Gerberdriasins A–F, six undescribed coumarin derivatives from <i>Gerbera anandria</i> (Linn) Sch-Bip and their protective effects on scopolamine-induced injury in PC12 cells" @default.
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- W4286356160 doi "https://doi.org/10.1039/d2ra03166c" @default.
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