Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286357598> ?p ?o ?g. }
- W4286357598 endingPage "57" @default.
- W4286357598 startingPage "50" @default.
- W4286357598 abstract "BACKGROUND: It is known that a considerable number of drugs in clinical use or under development are water-insoluble drugs with poor bioavailability. The liposomal delivery system has drawn attention as one of the noteworthy approaches to increase both dissolution and absorption because of its biocompatibility and ability to encapsulate hydrophobic molecules in the lipid domain. However, several drawbacks have been reported, the most common is liposome structural instability . OBJECTIVE: To encapsulate alpha tocopherol into liposomes, to determine the new formulation stability and to study the drug-release of alpha tocopherol into the sperm cryopreservation medium. MATERIALS AND METHODS: The liposomes prepared by an ethanol injection method were characterized for size stability, alpha tocopherol release and sperm motility tests. RESULTS: The prepared unilamellar vesicles had both narrow size distribution (around 99 nm) and a good physical and chemical stability at 4°C during 12 months. The liposomes did not release the vitamin E immediately, but retained the protectant for 24 hours, probably due to the rigidity of the liposomal fence which was reinforced by adding cholesterol. Then, all vitamin E molecules were released by 48 hours. Release was potentially by Fickian diffusion probably by the creation of mini-ducts due to both agitation and fence hydration. Moreover, semen motility treated with vitamin E liposome preparations was significantly improved compared to all other treatments (including commonly used sperm conservation media). CONCLUSION : The stable vitamin E liposomes formulated in this work are a promising alternative for semen cryopreservation protection." @default.
- W4286357598 created "2022-07-21" @default.
- W4286357598 creator A5008536585 @default.
- W4286357598 creator A5023589722 @default.
- W4286357598 creator A5030802800 @default.
- W4286357598 creator A5038134309 @default.
- W4286357598 creator A5060848661 @default.
- W4286357598 creator A5082294887 @default.
- W4286357598 date "2022-01-01" @default.
- W4286357598 modified "2023-10-16" @default.
- W4286357598 title "Drug Release, Stability And Efficiency Of Vitamin E Loaded In Liposomes For Bovine Sperm Protection In Cryopreservation Medium" @default.
- W4286357598 cites W1949122484 @default.
- W4286357598 cites W1965711466 @default.
- W4286357598 cites W1987843843 @default.
- W4286357598 cites W1996208962 @default.
- W4286357598 cites W1997105512 @default.
- W4286357598 cites W2000226272 @default.
- W4286357598 cites W2001943417 @default.
- W4286357598 cites W2013141559 @default.
- W4286357598 cites W2018066310 @default.
- W4286357598 cites W2025680762 @default.
- W4286357598 cites W2038225831 @default.
- W4286357598 cites W2059184743 @default.
- W4286357598 cites W2060526135 @default.
- W4286357598 cites W2061510929 @default.
- W4286357598 cites W2066080860 @default.
- W4286357598 cites W2082865634 @default.
- W4286357598 cites W2084941491 @default.
- W4286357598 cites W2094569055 @default.
- W4286357598 cites W2095382272 @default.
- W4286357598 cites W2102089901 @default.
- W4286357598 cites W2115439624 @default.
- W4286357598 cites W2155195157 @default.
- W4286357598 cites W2166458266 @default.
- W4286357598 cites W2545660909 @default.
- W4286357598 cites W2560952980 @default.
- W4286357598 cites W2735150307 @default.
- W4286357598 cites W2754792841 @default.
- W4286357598 cites W2780935590 @default.
- W4286357598 cites W2810900124 @default.
- W4286357598 cites W2884193607 @default.
- W4286357598 cites W2902253808 @default.
- W4286357598 cites W2965352872 @default.
- W4286357598 cites W2991301011 @default.
- W4286357598 cites W3010572615 @default.
- W4286357598 cites W3011686755 @default.
- W4286357598 cites W3040413990 @default.
- W4286357598 cites W3082281885 @default.
- W4286357598 doi "https://doi.org/10.54680/fr22110110612" @default.
- W4286357598 hasPublicationYear "2022" @default.
- W4286357598 type Work @default.
- W4286357598 citedByCount "2" @default.
- W4286357598 countsByYear W42863575982023 @default.
- W4286357598 crossrefType "journal-article" @default.
- W4286357598 hasAuthorship W4286357598A5008536585 @default.
- W4286357598 hasAuthorship W4286357598A5023589722 @default.
- W4286357598 hasAuthorship W4286357598A5030802800 @default.
- W4286357598 hasAuthorship W4286357598A5038134309 @default.
- W4286357598 hasAuthorship W4286357598A5060848661 @default.
- W4286357598 hasAuthorship W4286357598A5082294887 @default.
- W4286357598 hasConcept C12554922 @default.
- W4286357598 hasConcept C16685009 @default.
- W4286357598 hasConcept C178790620 @default.
- W4286357598 hasConcept C179933525 @default.
- W4286357598 hasConcept C185154212 @default.
- W4286357598 hasConcept C185592680 @default.
- W4286357598 hasConcept C196843134 @default.
- W4286357598 hasConcept C2777551382 @default.
- W4286357598 hasConcept C2777632594 @default.
- W4286357598 hasConcept C2778004101 @default.
- W4286357598 hasConcept C2778093475 @default.
- W4286357598 hasConcept C2779820397 @default.
- W4286357598 hasConcept C2781087480 @default.
- W4286357598 hasConcept C2781449162 @default.
- W4286357598 hasConcept C43617362 @default.
- W4286357598 hasConcept C55493867 @default.
- W4286357598 hasConcept C71924100 @default.
- W4286357598 hasConcept C86803240 @default.
- W4286357598 hasConcept C95444343 @default.
- W4286357598 hasConcept C98274493 @default.
- W4286357598 hasConceptScore W4286357598C12554922 @default.
- W4286357598 hasConceptScore W4286357598C16685009 @default.
- W4286357598 hasConceptScore W4286357598C178790620 @default.
- W4286357598 hasConceptScore W4286357598C179933525 @default.
- W4286357598 hasConceptScore W4286357598C185154212 @default.
- W4286357598 hasConceptScore W4286357598C185592680 @default.
- W4286357598 hasConceptScore W4286357598C196843134 @default.
- W4286357598 hasConceptScore W4286357598C2777551382 @default.
- W4286357598 hasConceptScore W4286357598C2777632594 @default.
- W4286357598 hasConceptScore W4286357598C2778004101 @default.
- W4286357598 hasConceptScore W4286357598C2778093475 @default.
- W4286357598 hasConceptScore W4286357598C2779820397 @default.
- W4286357598 hasConceptScore W4286357598C2781087480 @default.
- W4286357598 hasConceptScore W4286357598C2781449162 @default.
- W4286357598 hasConceptScore W4286357598C43617362 @default.
- W4286357598 hasConceptScore W4286357598C55493867 @default.
- W4286357598 hasConceptScore W4286357598C71924100 @default.
- W4286357598 hasConceptScore W4286357598C86803240 @default.