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• W4286375552 abstract "GPR158 is an orphan G protein-coupled receptor (GPCR) that is broadly expressed in the brain and displays unique structural characteristics and signaling mechanisms. GPR158 is a binding partner for the regulator of G protein signaling 7 (RGS7) and augments its expression, subcellular localization, and catalytic activity. Recent cryo-electron microscopy (cryo-EM) studies have revealed the structure of GPR158 alone and in complex with RGS7. The GPR158-RGS7 complex is shown to be regulated by chronic stress exposure and is a modulator of stress-induced depression. This review highlights the signaling mechanism and function of GPR158-RGS7 and provides a context for the unique formation of GPCR-RGS complexes." @default.
• W4286375552 created "2022-07-21" @default.
• W4286375552 creator A5046284980 @default.
• W4286375552 creator A5055688524 @default.
• W4286375552 date "2022-01-01" @default.
• W4286375552 modified "2023-09-25" @default.
• W4286375552 title "The interaction, mechanism and function of GPR158-RGS7 cross-talk" @default.
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• W4286375552 doi "https://doi.org/10.1016/bs.pmbts.2022.06.007" @default.
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