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- W4286383407 abstract "Salivary gland-like breast tumors are rare and diagnostic challenging tumors. The tumors show similar histological features and molecular diagnostic alterations to their counterpart in the salivary glands, except for acinic cell carcinomas . Some tumors show a complex epithelial and myoepithelial composition (pleomorphic adenoma , basal cell adenoma, adenomyoepithelioma , and adenoid cystic carcinoma). In contrast, others are predominantly epithelial (polymorphous adenocarcinoma, mucoepidermoid carcinoma , secretory carcinoma, and acinic cell carcinoma). Some tumors are benign, while others are carcinomas of low malignant potential. Occasional cases show high-grade transformation and aggressive behavior, with distant metastases . Despite being triple-negative tumors, they do not require conventional chemotherapy in most instances, except for cases with high-grade histology and metastases. Limited experience exists in metastatic secretory carcinomas with pan-NTRK inhibitor therapy, which is promising. Los tumores de la mama tipo glándula salival son raros y de diagnóstico difícil. Estos tumores tienen características histológicas y alteraciones moleculares similares a sus tumores homólogos de la glándula salival, excepto los casos de carcinoma de células acinares. Algunos tumores muestran una composición compleja, estando formados por células epiteliales y mioepiteliales (adenoma pleomórfico, adenoma de células basales, adenomioepitelioma, carcinoma adenoide quístico). Otros tumores son predominantemente epiteliales (adenocarcinoma polimorfo, carcinoma mucoepidermoide, carcinoma secretor, carcinoma de células acinares). Algunos tumores son benignos y otros son carcinomas de bajo potencial de malignidad. Ocasionalmente, estos tumores muestran transformación de alto grado y comportamiento agresivo, con metastasis a distancia. A pesar de ser tumores triple-negativos, no requieren quimioterpia convencional en la mayoría de los casos, excepto los casos con histología de alto grado y metástasis. Existe una limitada experiencia en el tratamiento del carcinoma secretor metastásico con inhibidores de pan-NTRK, con resultados prometedores." @default.
- W4286383407 created "2022-07-22" @default.
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- W4286383407 date "2022-07-01" @default.
- W4286383407 modified "2023-09-30" @default.
- W4286383407 title "Salivary gland-like breast tumors: A review of diagnostic features and prognosis" @default.
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- W4286383407 doi "https://doi.org/10.1016/j.senol.2022.04.004" @default.
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