FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286436660> ?p ?o ?g. }

• W4286436660 endingPage "153271" @default.
• W4286436660 startingPage "153271" @default.
• W4286436660 abstract "Air pollution is a public health threat and global epidemiological studies have shown that ambient air pollutants are closely related to various poor health conditions, including neurodegenerative diseases. Here, we evaluated the toxic effects and the underlying mechanisms of fine airborne particulate matter (PM2.5) on human glioblastoma LN-229 cells. Our results showed that exposure of LN-229 cells to PM2.5 (≥ 200 μg/mL) significantly reduced cell viability. PM2.5 exposure increased autophagy, apoptosis, and ROS production in the cells. Pre-treatment with a ROS scavenger, catalase, or depletion of mtDNA (ρ0 cells) abolished PM2.5-induced autophagy and apoptosis. PM2.5 exposure also activated MAPK signals in cells, which were blocked by catalase pre-treatment or mtDNA depletion. Furthermore, inhibition of JNK, but not ERK1/2 or p38, attenuated PM2.5-induced autophagy and apoptosis in cells. Finally, suppression of autophagy with Bafilomycin A1 or Beclin 1 siRNA exacerbated PM2.5-induced apoptosis, indicating a protective role of autophagy against PM2.5-induced apoptosis. Our results demonstrated that exposure of LN-229 cells to PM2.5 caused autophagy and apoptosis through PM2.5-induced ROS generation, mainly by mitochondria, and JNK activation. Autophagy may have a transient protective response in PM2.5-induced apoptosis. These findings have important implications for understanding the potential neurotoxicity of PM2.5." @default.
• W4286436660 created "2022-07-22" @default.
• W4286436660 creator A5003371947 @default.
• W4286436660 creator A5003794405 @default.
• W4286436660 creator A5010776860 @default.
• W4286436660 creator A5017244097 @default.
• W4286436660 creator A5019052956 @default.
• W4286436660 creator A5022706237 @default.
• W4286436660 date "2022-07-01" @default.
• W4286436660 modified "2023-09-26" @default.
• W4286436660 title "A protective role of autophagy in fine airborne particulate matter-induced apoptosis in LN-229 cells" @default.
• W4286436660 cites W1480951384 @default.
• W4286436660 cites W1513946969 @default.
• W4286436660 cites W1539342474 @default.
• W4286436660 cites W1550589316 @default.
• W4286436660 cites W1553524486 @default.
• W4286436660 cites W1555144266 @default.
• W4286436660 cites W172276776 @default.
• W4286436660 cites W1780295430 @default.
• W4286436660 cites W1988542962 @default.
• W4286436660 cites W1990738892 @default.
• W4286436660 cites W1993996670 @default.
• W4286436660 cites W1999211990 @default.
• W4286436660 cites W2010340076 @default.
• W4286436660 cites W2034116049 @default.
• W4286436660 cites W2034132952 @default.
• W4286436660 cites W2037905234 @default.
• W4286436660 cites W2043297200 @default.
• W4286436660 cites W2044621729 @default.
• W4286436660 cites W2048776263 @default.
• W4286436660 cites W20515147 @default.
• W4286436660 cites W2066404923 @default.
• W4286436660 cites W2072535567 @default.
• W4286436660 cites W2072816579 @default.
• W4286436660 cites W2079790626 @default.
• W4286436660 cites W2081145901 @default.
• W4286436660 cites W2087348016 @default.
• W4286436660 cites W2094599199 @default.
• W4286436660 cites W2106988699 @default.
• W4286436660 cites W2111127953 @default.
• W4286436660 cites W2121429373 @default.
• W4286436660 cites W2121966499 @default.
• W4286436660 cites W2133801172 @default.
• W4286436660 cites W2151253668 @default.
• W4286436660 cites W2218192779 @default.
• W4286436660 cites W222006012 @default.
• W4286436660 cites W2325021767 @default.
• W4286436660 cites W2410919115 @default.
• W4286436660 cites W2529390893 @default.
• W4286436660 cites W2775815660 @default.
• W4286436660 cites W2792025613 @default.
• W4286436660 cites W2794644642 @default.
• W4286436660 cites W2805952973 @default.
• W4286436660 cites W2885509648 @default.
• W4286436660 cites W2886059981 @default.
• W4286436660 cites W2922417724 @default.
• W4286436660 cites W2942859470 @default.
• W4286436660 cites W2986778737 @default.
• W4286436660 cites W2989892704 @default.
• W4286436660 cites W2990638839 @default.
• W4286436660 cites W3008579488 @default.
• W4286436660 cites W3013207020 @default.
• W4286436660 cites W3063760387 @default.
• W4286436660 cites W3083416415 @default.
• W4286436660 cites W3092966039 @default.
• W4286436660 cites W3093459267 @default.
• W4286436660 cites W3098441039 @default.
• W4286436660 cites W3108610826 @default.
• W4286436660 cites W3110853227 @default.
• W4286436660 cites W3113536907 @default.
• W4286436660 cites W3129009349 @default.
• W4286436660 cites W3136688855 @default.
• W4286436660 cites W3171124897 @default.
• W4286436660 cites W4249336109 @default.
• W4286436660 cites W4254119740 @default.
• W4286436660 cites W4362172418 @default.
• W4286436660 doi "https://doi.org/10.1016/j.tox.2022.153271" @default.
• W4286436660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35872226" @default.
• W4286436660 hasPublicationYear "2022" @default.
• W4286436660 type Work @default.
• W4286436660 citedByCount "0" @default.
• W4286436660 crossrefType "journal-article" @default.
• W4286436660 hasAuthorship W4286436660A5003371947 @default.
• W4286436660 hasAuthorship W4286436660A5003794405 @default.
• W4286436660 hasAuthorship W4286436660A5010776860 @default.
• W4286436660 hasAuthorship W4286436660A5017244097 @default.
• W4286436660 hasAuthorship W4286436660A5019052956 @default.
• W4286436660 hasAuthorship W4286436660A5022706237 @default.
• W4286436660 hasConcept C178790620 @default.
• W4286436660 hasConcept C185592680 @default.
• W4286436660 hasConcept C190283241 @default.
• W4286436660 hasConcept C203522944 @default.
• W4286436660 hasConcept C2776151105 @default.
• W4286436660 hasConcept C2777722557 @default.
• W4286436660 hasConcept C2778175917 @default.
• W4286436660 hasConcept C2778979269 @default.
• W4286436660 hasConcept C2779491297 @default.
• W4286436660 hasConcept C29730261 @default.

• next