FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286447655> ?p ?o ?g. }

• W4286447655 abstract "Objectives This retrospective study sought to investigate the risk and proportion of gonadal neoplasms in phenotypic female pediatric patients with DSD and the presence of the Y chromosome and different genetic backgrounds in a single Chinese center. Materials and Methods From January 2012 to December 2020, pediatric and adolescent patients with DSD and the presence of the Y chromosome who had unambiguous female genitalia and underwent bilateral gonadectomy or gonadal biopsy were included in this study. Patients’ demographics, karyotype, laboratory test results, gross pathology, and histology of gonadal tissue were all collected. The patients were divided into three groups based on their different genetic backgrounds, and the percentage of gonadal tumors was calculated to assess the risk of gonadal tumor and malignancy by etiology. Results A total of 22 patients with DSD and an unambiguous female phenotype with a Y chromosome were recruited. The mean age was 10.91 ± 4.99 years (9 months to 19 years). Gonadal neoplasia was confirmed in six (27.3%) cases by pathological examination of surgical gonadal tissue samples. Among 44 gonadal samples from these 22 patients, the following were identified: five gonadoblastomas, three dysgerminomas, and two Leydig cell tumors. The youngest patient with a tumor was a 2-year-old girl with 46,XY complete gonadal dysgenesis (46,XY CGD or Swyer syndrome) and bilateral gonadoblastoma. Patients with 46,XY complete gonadal dysgenesis (4/6; 66.7%) had the highest tumor occurrence rate. Among 10 patients with Turner syndrome with the presence of the Y chromosome, only one patient was diagnosed with a gonadal tumor. Leydig cell tumor was diagnosed in only one of six patients with 46,XY androgen synthesis/action disorders. Conclusion Pediatric patients with 46,XY complete gonadal dysgenesis had a significantly increased risk of developing gonadal tumors and underwent prophylactic gonadectomy as soon as the diagnosis was confirmed, whereas those with Turner syndrome with Y chromosome and 46,XY androgen synthesis/action disorders had a relatively low risk. In view of the limited number of patients, a large multicenter study with close follow-ups is needed to support these conclusions." @default.
• W4286447655 created "2022-07-22" @default.
• W4286447655 creator A5022326948 @default.
• W4286447655 creator A5024188214 @default.
• W4286447655 creator A5044936528 @default.
• W4286447655 date "2022-07-22" @default.
• W4286447655 modified "2023-09-30" @default.
• W4286447655 title "Gonadal tumor risk in pediatric and adolescent phenotypic females with disorders of sex development and Y chromosomal constitution with different genetic etiologies" @default.
• W4286447655 cites W1746088225 @default.
• W4286447655 cites W1876187171 @default.
• W4286447655 cites W1974597510 @default.
• W4286447655 cites W1985543856 @default.
• W4286447655 cites W1998033340 @default.
• W4286447655 cites W2009171567 @default.
• W4286447655 cites W2020611882 @default.
• W4286447655 cites W2054268095 @default.
• W4286447655 cites W2062263904 @default.
• W4286447655 cites W2065868868 @default.
• W4286447655 cites W2072013425 @default.
• W4286447655 cites W2077746313 @default.
• W4286447655 cites W2080711382 @default.
• W4286447655 cites W2081983661 @default.
• W4286447655 cites W2114346198 @default.
• W4286447655 cites W2124844058 @default.
• W4286447655 cites W2125130956 @default.
• W4286447655 cites W2128005191 @default.
• W4286447655 cites W2129295306 @default.
• W4286447655 cites W2144254428 @default.
• W4286447655 cites W2144357013 @default.
• W4286447655 cites W2145361683 @default.
• W4286447655 cites W2150695541 @default.
• W4286447655 cites W2156526029 @default.
• W4286447655 cites W2162829213 @default.
• W4286447655 cites W2178394645 @default.
• W4286447655 cites W2284518822 @default.
• W4286447655 cites W2290319078 @default.
• W4286447655 cites W2296216892 @default.
• W4286447655 cites W2512567399 @default.
• W4286447655 cites W2518796137 @default.
• W4286447655 cites W2530491399 @default.
• W4286447655 cites W2531253057 @default.
• W4286447655 cites W2613704658 @default.
• W4286447655 cites W2617084359 @default.
• W4286447655 cites W2768300546 @default.
• W4286447655 cites W2780799896 @default.
• W4286447655 cites W2922255797 @default.
• W4286447655 cites W2971314430 @default.
• W4286447655 cites W3004658380 @default.
• W4286447655 cites W3195819066 @default.
• W4286447655 cites W3197473370 @default.
• W4286447655 cites W4210671949 @default.
• W4286447655 cites W4232753436 @default.
• W4286447655 cites W4251038717 @default.
• W4286447655 doi "https://doi.org/10.3389/fped.2022.856128" @default.
• W4286447655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35935368" @default.
• W4286447655 hasPublicationYear "2022" @default.
• W4286447655 type Work @default.
• W4286447655 citedByCount "1" @default.
• W4286447655 countsByYear W42864476552023 @default.
• W4286447655 crossrefType "journal-article" @default.
• W4286447655 hasAuthorship W4286447655A5022326948 @default.
• W4286447655 hasAuthorship W4286447655A5024188214 @default.
• W4286447655 hasAuthorship W4286447655A5044936528 @default.
• W4286447655 hasBestOaLocation W42864476551 @default.
• W4286447655 hasConcept C104317684 @default.
• W4286447655 hasConcept C126322002 @default.
• W4286447655 hasConcept C137627325 @default.
• W4286447655 hasConcept C142724271 @default.
• W4286447655 hasConcept C2778324535 @default.
• W4286447655 hasConcept C2779272188 @default.
• W4286447655 hasConcept C2779399171 @default.
• W4286447655 hasConcept C2779683239 @default.
• W4286447655 hasConcept C2780246931 @default.
• W4286447655 hasConcept C29456083 @default.
• W4286447655 hasConcept C30481170 @default.
• W4286447655 hasConcept C53226629 @default.
• W4286447655 hasConcept C54355233 @default.
• W4286447655 hasConcept C71924100 @default.
• W4286447655 hasConcept C86803240 @default.
• W4286447655 hasConceptScore W4286447655C104317684 @default.
• W4286447655 hasConceptScore W4286447655C126322002 @default.
• W4286447655 hasConceptScore W4286447655C137627325 @default.
• W4286447655 hasConceptScore W4286447655C142724271 @default.
• W4286447655 hasConceptScore W4286447655C2778324535 @default.
• W4286447655 hasConceptScore W4286447655C2779272188 @default.
• W4286447655 hasConceptScore W4286447655C2779399171 @default.
• W4286447655 hasConceptScore W4286447655C2779683239 @default.
• W4286447655 hasConceptScore W4286447655C2780246931 @default.
• W4286447655 hasConceptScore W4286447655C29456083 @default.
• W4286447655 hasConceptScore W4286447655C30481170 @default.
• W4286447655 hasConceptScore W4286447655C53226629 @default.
• W4286447655 hasConceptScore W4286447655C54355233 @default.
• W4286447655 hasConceptScore W4286447655C71924100 @default.
• W4286447655 hasConceptScore W4286447655C86803240 @default.
• W4286447655 hasLocation W42864476551 @default.
• W4286447655 hasLocation W42864476552 @default.
• W4286447655 hasLocation W42864476553 @default.
• W4286447655 hasOpenAccess W4286447655 @default.
• W4286447655 hasPrimaryLocation W42864476551 @default.
• W4286447655 hasRelatedWork W2018278391 @default.

• next