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- W4286485011 abstract "The multivalent nanobody TNF inhibitor ozoralizumab could be a safe and effective treatment for rheumatoid arthritis, according to the results of a phase 2/3 randomised trial by Tsutomu Takeuchi and colleagues. 381 patients were randomly assigned to receive 30 mg ozoralizumab (n=152), 80 mg ozoralizumab (n=154), or placebo (n=75) subcutaneously every 4 weeks concomitant with methotrexate (6–16 mg/week) for 24 weeks. At week 16, 121 (79·6%) of patients on 30 mg ozoralizumab and 116 (75·3%) on 80 mg ozoralizumab had a 20% improvement in the American College of Rheumatology criteria (ACR20 response; the primary outcome) versus 28 (37·3%) on placebo (p<0·0001 for both doses). Serious adverse events occurred in four (2·6%) patients on 30 mg ozoralizumab, four (2·6%) on 80 mg ozoralizumab, and two (2·7%) on placebo; one death occurred in the 80 mg ozoralizumab group (due to disseminated tuberculosis, deemed to be causally related to the study drug)." @default.
- W4286485011 created "2022-07-22" @default.
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- W4286485011 date "2022-08-01" @default.
- W4286485011 modified "2023-09-30" @default.
- W4286485011 title "Research in Brief" @default.
- W4286485011 doi "https://doi.org/10.1016/s2665-9913(22)00196-5" @default.
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