Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286490116> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4286490116 abstract "Abstract Background: The tetratricopeptide repeat domain 39C ( TTC39C ) gene is a novel TTC genes, which mainly mediates the interaction between proteins. It has been shown to be involved in the progression of a variety of tumors. Here we aimed to identify the effect of TTC39C on lung adenocarcinoma, which can be used as potential intervention targets. Methods: Take samples from TCGA database for difference analysis of TTC39C. Transwell experiment was used to detect the ability of cell metastasis. Celigo and MTT assay detected the effect of TTC39C gene subtraction on cell proliferation. FACS was used to detect the effect of TTC39C gene subtraction on apoptosis. Clonal formation experiment was used to detect the effect of TTC39C gene subtraction on clonal ability. Transcriptomics, proteomics and metabolomics were used to study the possible enrichment pathway of TTC39C gene in the progression of lung adenocarcinoma. Results: TTC39C expression was significantly increased in lung adenocarcinoma. the proliferation, metastasis and cloning ability of human lung cancer cells were inhibited, while the apoptosis of cells increased significantly after TTC39C depletion. It is concluded that TTC39C may be involved in the progression of LUAD mainly through metabolic pathway and p53 pathway through transcriptomics combined with proteomics and metabolomics. Conclusion: In summary, TTC39C plays an important role in regulating the proliferation and metastasis of lung adenocarcinoma cells. The main pathways involved in TTC39C in lung adenocarcinoma mainly include energy metabolism and p53 pathway." @default.
- W4286490116 created "2022-07-22" @default.
- W4286490116 creator A5016463853 @default.
- W4286490116 creator A5032241163 @default.
- W4286490116 creator A5046245231 @default.
- W4286490116 creator A5062388901 @default.
- W4286490116 creator A5082859400 @default.
- W4286490116 date "2022-07-21" @default.
- W4286490116 modified "2023-09-26" @default.
- W4286490116 title "TTC39C may be a new target for the treatment of lung adenocarcinoma" @default.
- W4286490116 doi "https://doi.org/10.21203/rs.3.rs-1839531/v1" @default.
- W4286490116 hasPublicationYear "2022" @default.
- W4286490116 type Work @default.
- W4286490116 citedByCount "0" @default.
- W4286490116 crossrefType "posted-content" @default.
- W4286490116 hasAuthorship W4286490116A5016463853 @default.
- W4286490116 hasAuthorship W4286490116A5032241163 @default.
- W4286490116 hasAuthorship W4286490116A5046245231 @default.
- W4286490116 hasAuthorship W4286490116A5062388901 @default.
- W4286490116 hasAuthorship W4286490116A5082859400 @default.
- W4286490116 hasBestOaLocation W42864901161 @default.
- W4286490116 hasConcept C104317684 @default.
- W4286490116 hasConcept C121608353 @default.
- W4286490116 hasConcept C143998085 @default.
- W4286490116 hasConcept C150194340 @default.
- W4286490116 hasConcept C162317418 @default.
- W4286490116 hasConcept C173396325 @default.
- W4286490116 hasConcept C190283241 @default.
- W4286490116 hasConcept C2776256026 @default.
- W4286490116 hasConcept C2779013556 @default.
- W4286490116 hasConcept C2781182431 @default.
- W4286490116 hasConcept C46111723 @default.
- W4286490116 hasConcept C502942594 @default.
- W4286490116 hasConcept C54355233 @default.
- W4286490116 hasConcept C62112901 @default.
- W4286490116 hasConcept C71924100 @default.
- W4286490116 hasConcept C86803240 @default.
- W4286490116 hasConceptScore W4286490116C104317684 @default.
- W4286490116 hasConceptScore W4286490116C121608353 @default.
- W4286490116 hasConceptScore W4286490116C143998085 @default.
- W4286490116 hasConceptScore W4286490116C150194340 @default.
- W4286490116 hasConceptScore W4286490116C162317418 @default.
- W4286490116 hasConceptScore W4286490116C173396325 @default.
- W4286490116 hasConceptScore W4286490116C190283241 @default.
- W4286490116 hasConceptScore W4286490116C2776256026 @default.
- W4286490116 hasConceptScore W4286490116C2779013556 @default.
- W4286490116 hasConceptScore W4286490116C2781182431 @default.
- W4286490116 hasConceptScore W4286490116C46111723 @default.
- W4286490116 hasConceptScore W4286490116C502942594 @default.
- W4286490116 hasConceptScore W4286490116C54355233 @default.
- W4286490116 hasConceptScore W4286490116C62112901 @default.
- W4286490116 hasConceptScore W4286490116C71924100 @default.
- W4286490116 hasConceptScore W4286490116C86803240 @default.
- W4286490116 hasLocation W42864901161 @default.
- W4286490116 hasOpenAccess W4286490116 @default.
- W4286490116 hasPrimaryLocation W42864901161 @default.
- W4286490116 hasRelatedWork W2054174996 @default.
- W4286490116 hasRelatedWork W2081501617 @default.
- W4286490116 hasRelatedWork W2150881491 @default.
- W4286490116 hasRelatedWork W2600717990 @default.
- W4286490116 hasRelatedWork W2757171608 @default.
- W4286490116 hasRelatedWork W2781680339 @default.
- W4286490116 hasRelatedWork W2908335280 @default.
- W4286490116 hasRelatedWork W3012091774 @default.
- W4286490116 hasRelatedWork W3093576163 @default.
- W4286490116 hasRelatedWork W3185922740 @default.
- W4286490116 isParatext "false" @default.
- W4286490116 isRetracted "false" @default.
- W4286490116 workType "article" @default.