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• W4286500618 endingPage "4245" @default.
• W4286500618 startingPage "4227" @default.
• W4286500618 abstract "In patients with chronic obstructive pulmonary disease (COPD), exertional dyspnoea generally arises when there is imbalance between ventilatory demand and capacity, but the neurophysiological mechanisms are unclear. We therefore determined if disparity between elevated inspiratory neural drive (IND) and tidal volume (VT ) responses (neuromechanical dissociation) impacted dyspnoea intensity and quality during exercise, across the COPD severity spectrum. In this two-centre, cross-sectional observational study, 89 participants with COPD divided into tertiles of FEV1 %predicted (Tertile 1 = FEV1 = 87 ± 9%, Tertile 2 = 60 ± 9%, Tertile 3 = 32 ± 8%) and 18 non-smoking controls, completed a symptom-limited cardiopulmonary exercise test (CPET) with measurement of IND by diaphragm electromyography (EMGdi (%max)). The association between increasing dyspnoea intensity and EMGdi (%max) during CPET was strong (r = 0.730, P < 0.001) and not different between the four groups who showed marked heterogeneity in pulmonary gas exchange and mechanical abnormalities. Significant inspiratory constraints (tidal volume/inspiratory capacity (VT /IC) ≥ 70%) and onset of neuromechanical dissociation (EMGdi (%max):VT /IC > 0.75) occurred at progressively lower minute ventilation ( V̇E${dot{V}}_{{rm{E}}}$ ) from Control to Tertile 3. Lower resting IC meant earlier onset of neuromechanical dissociation, heightened dyspnoea intensity and greater propensity (93% in Tertile 3) to select qualitative descriptors of 'unsatisfied inspiration'. We concluded that, regardless of marked variation in mechanical and pulmonary gas exchange abnormalities in our study sample, exertional dyspnoea intensity was linked to the magnitude of EMGdi (%max). Moreover, onset of critical inspiratory constraints and attendant neuromechanical dissociation amplified dyspnoea intensity at higher exercise intensities. Simple measurements of IC and breathing pattern during CPET provide useful insights into mechanisms of dyspnoea and exercise intolerance in individuals with COPD. KEY POINTS: Dyspnoea during exercise is a common and troublesome symptom reported by patients with chronic obstructive pulmonary disease (COPD) and is linked to an elevated inspiratory neural drive (IND). The precise mechanisms of elevated IND and dyspnoea across the continuum of airflow obstruction severity in COPD remains unclear. The present study sought to determine the mechanisms of elevated IND (by diaphragm EMG, EMGdi (%max)) and dyspnoea during cardiopulmonary exercise testing (CPET) across the continuum of COPD severity. There was a strong association between increasing dyspnoea intensity and EMGdi (%max) during CPET across the COPD continuum despite significant heterogeneity in underlying pulmonary gas exchange and respiratory mechanical impairments. Critical inspiratory constraints occurred at progressively lower ventilation during exercise with worsening severity of COPD. This was associated with the progressively lower resting inspiratory capacity with worsening disease severity. Earlier critical inspiratory constraint was associated with earlier neuromechanical dissociation and greater likelihood of reporting the sensation of 'unsatisfied inspiration'." @default.
• W4286500618 created "2022-07-22" @default.
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• W4286500618 date "2022-08-05" @default.
• W4286500618 modified "2023-10-18" @default.
• W4286500618 title "Exertional dyspnoea in patients with mild‐to‐severe chronic obstructive pulmonary disease: neuromechanical mechanisms" @default.
• W4286500618 cites W1568232604 @default.
• W4286500618 cites W1756024634 @default.
• W4286500618 cites W1788656089 @default.
• W4286500618 cites W1909929741 @default.
• W4286500618 cites W1912369005 @default.
• W4286500618 cites W1918044012 @default.
• W4286500618 cites W1927839424 @default.
• W4286500618 cites W1929641254 @default.
• W4286500618 cites W1930538820 @default.
• W4286500618 cites W1958131677 @default.
• W4286500618 cites W1962642077 @default.
• W4286500618 cites W1972654327 @default.
• W4286500618 cites W1981434879 @default.
• W4286500618 cites W1981671170 @default.
• W4286500618 cites W1986814530 @default.
• W4286500618 cites W1987605472 @default.
• W4286500618 cites W1988226846 @default.
• W4286500618 cites W1990380901 @default.
• W4286500618 cites W1990881156 @default.
• W4286500618 cites W2000353630 @default.
• W4286500618 cites W2000545021 @default.
• W4286500618 cites W2000993407 @default.
• W4286500618 cites W2001097201 @default.
• W4286500618 cites W2004008756 @default.
• W4286500618 cites W2006650030 @default.
• W4286500618 cites W2011406495 @default.
• W4286500618 cites W2015008153 @default.
• W4286500618 cites W2021804364 @default.
• W4286500618 cites W2040959481 @default.
• W4286500618 cites W2043862418 @default.
• W4286500618 cites W2052964857 @default.
• W4286500618 cites W2062334089 @default.
• W4286500618 cites W2062877003 @default.
• W4286500618 cites W2066402174 @default.
• W4286500618 cites W2072085637 @default.
• W4286500618 cites W2074174707 @default.
• W4286500618 cites W2082101173 @default.
• W4286500618 cites W2085898803 @default.
• W4286500618 cites W2099449365 @default.
• W4286500618 cites W2100710359 @default.
• W4286500618 cites W2104718264 @default.
• W4286500618 cites W2108403907 @default.
• W4286500618 cites W2115656863 @default.
• W4286500618 cites W2120199320 @default.
• W4286500618 cites W2120213912 @default.
• W4286500618 cites W2123028443 @default.
• W4286500618 cites W2123243410 @default.
• W4286500618 cites W2126681890 @default.
• W4286500618 cites W2128288283 @default.
• W4286500618 cites W2134688398 @default.
• W4286500618 cites W2137692110 @default.
• W4286500618 cites W2139993058 @default.
• W4286500618 cites W2141922649 @default.
• W4286500618 cites W2145676647 @default.
• W4286500618 cites W2146965595 @default.
• W4286500618 cites W2151001381 @default.
• W4286500618 cites W2152906506 @default.
• W4286500618 cites W2156831035 @default.
• W4286500618 cites W2157968241 @default.
• W4286500618 cites W2158984839 @default.
• W4286500618 cites W2163457410 @default.
• W4286500618 cites W2164101297 @default.
• W4286500618 cites W2166780351 @default.
• W4286500618 cites W2167898167 @default.
• W4286500618 cites W2172741173 @default.
• W4286500618 cites W2206899609 @default.
• W4286500618 cites W2409277485 @default.
• W4286500618 cites W2472304112 @default.
• W4286500618 cites W2484791473 @default.
• W4286500618 cites W2755145368 @default.
• W4286500618 cites W2791379775 @default.
• W4286500618 cites W2892160145 @default.
• W4286500618 cites W2943840688 @default.
• W4286500618 cites W2965632267 @default.
• W4286500618 cites W2981067716 @default.
• W4286500618 cites W3012488966 @default.
• W4286500618 cites W3042198919 @default.
• W4286500618 cites W3047597075 @default.
• W4286500618 cites W3089100525 @default.
• W4286500618 cites W3096945620 @default.
• W4286500618 cites W3119399166 @default.
• W4286500618 cites W3127796758 @default.
• W4286500618 cites W3134102052 @default.

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