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• W4286501660 endingPage "4639" @default.
• W4286501660 startingPage "4639" @default.
• W4286501660 abstract "Investigating novel compounds that may be useful in designing new, less toxic, selective, and potent breast anticancer agents is still the main challenge for medicinal chemists. Thus, in the present work, acetylthiophene was used as a building block to synthesize a novel series of thiazole-bearing thiophene derivatives. The structures of the synthesized compounds were elucidated based on elemental analysis and spectral measurements. The cytotoxic activities of the synthesized compounds were evaluated against MCF-7 tumor cells and compared to a cisplatin reference drug, and against the LLC-Mk2 normal cell line using the MTT assay, and the results revealed promising activities for compounds 4b and 13a. The active compounds were subjected to molecular modeling using MOE 2019, the pharmacokinetics were studied using SwissADME, and a toxicity radar was obtained from the biological screening data. The results obtained from the computational studies supported the results obtained from the anticancer biological studies." @default.
• W4286501660 created "2022-07-22" @default.
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• W4286501660 date "2022-07-20" @default.
• W4286501660 modified "2023-10-14" @default.
• W4286501660 title "Synthesis, Molecular Docking Study, and Cytotoxic Activity against MCF Cells of New Thiazole–Thiophene Scaffolds" @default.
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• W4286501660 doi "https://doi.org/10.3390/molecules27144639" @default.
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