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- W4286504000 abstract "The availability of natural substances able to fulfill the role of antioxidants in a physiologic environment is important for the development of therapies against diseases associated with excessive production of reactive oxygen species and ensuing oxidative stress. Antioxidant properties have been reported episodically for sericin, a proteinaceous constituent of the silk thread in the cocoons generated by the larvae of the Lepidoptera order. We investigated the sericin fractions isolated from the cocoons spun by the domesticated (Bombyx mori) silkworm. Three fractions were isolated and evaluated, including two peptidoid fractions, the crude sericin and the purified (dialyzed) sericin, and the non-peptidoid methanolic extract of the crude fraction. When subjected to Trolox equivalent antioxidant capacity (TEAC) assay, the extract showed much higher antioxidant capacity as compared to the crude or purified sericin fractions. The three fractions were also evaluated in cultures of murine retinal photoreceptor cells (661 W), a cell line that is highly susceptible to oxidants and is crucially involved in the retinopathies primarily caused by oxidative stress. The extract displayed a significant dose-dependent protective effect on the cultured cells exposed to hydrogen peroxide. In identical conditions, the crude sericin showed a certain level of antioxidative activity at a higher concentration, while the purified sericin did not show any activity. We concluded that the non-peptidoid components accompanying sericin were chiefly responsible for the previously reported antioxidant capacity associated with sericin fractions, a conclusion supported by the qualitative detection of flavonoids in the extract but not in the purified sericin fraction." @default.
- W4286504000 created "2022-07-22" @default.
- W4286504000 creator A5023155783 @default.
- W4286504000 creator A5031263732 @default.
- W4286504000 creator A5032838441 @default.
- W4286504000 date "2022-07-20" @default.
- W4286504000 modified "2023-10-14" @default.
- W4286504000 title "Study of the Antioxidative Effects of Bombyx mori Silk Sericin in Cultures of Murine Retinal Photoreceptor Cells" @default.
- W4286504000 cites W1558538004 @default.
- W4286504000 cites W1565000572 @default.
- W4286504000 cites W1614231230 @default.
- W4286504000 cites W1840078646 @default.
- W4286504000 cites W1964170890 @default.
- W4286504000 cites W1964665314 @default.
- W4286504000 cites W1965059144 @default.
- W4286504000 cites W1966483924 @default.
- W4286504000 cites W1967344233 @default.
- W4286504000 cites W1967377567 @default.
- W4286504000 cites W1969214190 @default.
- W4286504000 cites W1973197599 @default.
- W4286504000 cites W1973632674 @default.
- W4286504000 cites W1978105235 @default.
- W4286504000 cites W1982472213 @default.
- W4286504000 cites W1985988760 @default.
- W4286504000 cites W1993464125 @default.
- W4286504000 cites W1997356810 @default.
- W4286504000 cites W2002716603 @default.
- W4286504000 cites W2003253820 @default.
- W4286504000 cites W2006688301 @default.
- W4286504000 cites W2007486199 @default.
- W4286504000 cites W2007649442 @default.
- W4286504000 cites W2008490744 @default.
- W4286504000 cites W2009750283 @default.
- W4286504000 cites W2012855138 @default.
- W4286504000 cites W2021234841 @default.
- W4286504000 cites W2021276082 @default.
- W4286504000 cites W2021814263 @default.
- W4286504000 cites W2022222693 @default.
- W4286504000 cites W2025607183 @default.
- W4286504000 cites W2029981489 @default.
- W4286504000 cites W2031283802 @default.
- W4286504000 cites W2032057286 @default.
- W4286504000 cites W2032877033 @default.
- W4286504000 cites W2037208492 @default.
- W4286504000 cites W2042509194 @default.
- W4286504000 cites W2046561857 @default.
- W4286504000 cites W2048775913 @default.
- W4286504000 cites W2054869205 @default.
- W4286504000 cites W2060368065 @default.
- W4286504000 cites W2061426580 @default.
- W4286504000 cites W2064175793 @default.
- W4286504000 cites W2064644800 @default.
- W4286504000 cites W2065922170 @default.
- W4286504000 cites W2075869234 @default.
- W4286504000 cites W2076504627 @default.
- W4286504000 cites W2077858184 @default.
- W4286504000 cites W2085013550 @default.
- W4286504000 cites W2092941085 @default.
- W4286504000 cites W2100429920 @default.
- W4286504000 cites W2103637364 @default.
- W4286504000 cites W2117702167 @default.
- W4286504000 cites W2120574479 @default.
- W4286504000 cites W2127553505 @default.
- W4286504000 cites W2132670562 @default.
- W4286504000 cites W2135245421 @default.
- W4286504000 cites W2141606379 @default.
- W4286504000 cites W2144479742 @default.
- W4286504000 cites W2149756786 @default.
- W4286504000 cites W2163649081 @default.
- W4286504000 cites W2168300796 @default.
- W4286504000 cites W2171312335 @default.
- W4286504000 cites W2193782215 @default.
- W4286504000 cites W2202554561 @default.
- W4286504000 cites W2213477978 @default.
- W4286504000 cites W2217172471 @default.
- W4286504000 cites W2217850601 @default.
- W4286504000 cites W2250405392 @default.
- W4286504000 cites W2315589142 @default.
- W4286504000 cites W2336275571 @default.
- W4286504000 cites W2383403191 @default.
- W4286504000 cites W2416029742 @default.
- W4286504000 cites W2419359437 @default.
- W4286504000 cites W2483853723 @default.
- W4286504000 cites W2490235379 @default.
- W4286504000 cites W2505333409 @default.
- W4286504000 cites W2516313847 @default.
- W4286504000 cites W2553157303 @default.
- W4286504000 cites W2604491676 @default.
- W4286504000 cites W2606037604 @default.
- W4286504000 cites W2611671269 @default.
- W4286504000 cites W2728264015 @default.
- W4286504000 cites W2740695644 @default.
- W4286504000 cites W2742919026 @default.
- W4286504000 cites W2765104909 @default.
- W4286504000 cites W2765543116 @default.
- W4286504000 cites W2770372368 @default.
- W4286504000 cites W2792981090 @default.
- W4286504000 cites W2799986334 @default.