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- W4286509648 abstract "To evaluate Stereotactic body radiotherapy (SBRT) in metastatic colorectal cancer (mCRC) and identify the benefit of the treatment by using a predictive algorithm.85 patients treated with SBRT for mCRC were retrospectively analyzed. The CLInical Categorical Algorithm (CLICAL©) was used to predict probability of relapse after SBRT. Variables pre-SBRT were tested for significance for time to relapse (TTR). The patients' CLICAL© score was the mean of sub-scores of each significant variable's effect on the endpoint. Patients with similar scores were grouped into four signatures dependent on level of benefit after SBRT.Median age was 69 years (42-88), 63 % had a performance status 0 and 47 % were treated for a single metastasis. At the time of the analysis, 90 % had relapsed (95 % out-of-field). Median TTR was 7.3 months (4.6-8.5), and the 2-year relapse-free rate was 15 % (95 %CI = 7-22). The CLICAL© signature III-IV predicted a low risk of relapse if receiving high dose SBRT to all metastases or to lung metastases only. Signature I-II had a short TTR, why SBRT for these patients was judged non-beneficial.The benefit from SBRT varies among mCRC patients. CLICAL© may serve as a screening tool for SBRT referrals but needs to be validated." @default.
- W4286509648 created "2022-07-22" @default.
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- W4286509648 date "2022-09-01" @default.
- W4286509648 modified "2023-10-15" @default.
- W4286509648 title "Predicting the benefit of stereotactic body radiotherapy of colorectal cancer metastases" @default.
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- W4286509648 cites W2028556505 @default.
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- W4286509648 cites W2061653825 @default.
- W4286509648 cites W2070360377 @default.
- W4286509648 cites W2072034139 @default.
- W4286509648 cites W2079620338 @default.
- W4286509648 cites W2083352053 @default.
- W4286509648 cites W2097537959 @default.
- W4286509648 cites W2100125385 @default.
- W4286509648 cites W2110069491 @default.
- W4286509648 cites W2111465076 @default.
- W4286509648 cites W2131110909 @default.
- W4286509648 cites W2142928555 @default.
- W4286509648 cites W2144326782 @default.
- W4286509648 cites W2166459387 @default.
- W4286509648 cites W2166756664 @default.
- W4286509648 cites W2170281599 @default.
- W4286509648 cites W2216911472 @default.
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- W4286509648 doi "https://doi.org/10.1016/j.ctro.2022.07.006" @default.
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