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- W4286511237 abstract "Depression is one of the common psychiatric diseases worldwide. Previous studies showed that chronic stress could increase defecation and inhibit weight gain; however, the effects of chronic stress on gastrointestinal peristalsis had not been clarified. To study the mechanisms of depression, chronic restraint stress (CRS) is widely used as a traditional depressive animal model. In this study, we investigate the effects of CRS on gastric emptying and intestinal propulsion in mice. Our results showed that the mice exhibited obvious depression-like behaviors 4 weeks after CRS. Compared with the control group, gastric emptying and intestinal propulsion were significantly decreased in the CRS group. Further, we examined the expression of ArhGEF18, a Rho-specific guanine nucleotide exchanging factor, which was significantly reduced in the gut in the CRS group. Therefore, CRS caused depressive behaviors and abnormal gastrointestinal function. The ArhGEF18-RhoA/Rho signaling pathway may be a potential mediator in the brain–gut axis under stress." @default.
- W4286511237 created "2022-07-22" @default.
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- W4286511237 date "2022-08-01" @default.
- W4286511237 modified "2023-09-26" @default.
- W4286511237 title "Chronic restraint stress induces gastrointestinal function alternation: A potential role of the ArhGEF18-RhoA/Rho signaling pathway in the brain–gut axis under stress" @default.
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- W4286511237 doi "https://doi.org/10.26599/sab.2022.9060015" @default.
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