Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286511497> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4286511497 endingPage "e631" @default.
- W4286511497 startingPage "e624" @default.
- W4286511497 abstract "The role of surgery in recurrent glioblastoma multiforme (GBM) remains a controversial topic. The goal of this study was to perform a case control analysis including time to tumor recurrence as an additional prognostic factor in order to determine which patients benefit most from repeat surgery.Our brain tumor database was reviewed over a 10-year period for all adult (≥18 years old) patients with primary isocitrate dehydrogenase wildtype GBM who received surgery for recurrent disease. These patients were then age, sex, and treatment matched to case controls from our institution who received medical therapy for recurrent disease.A total of 174 adult patients with GBM were included in the study, 87 patients who received surgery for recurrent GBM (surgery cohort) and 87 patients who did not receive surgery for recurrent GBM (nonsurgery cohort). The surgery cohort had longer overall survival (P = 0.0003) and postrecurrence survival (P = 0.001) than the nonsurgery cohort. When the surgery cohort was split into 2 groups on the basis of time to tumor recurrence, the long time to recurrence group (>6 months) demonstrated significantly increased survival compared with the short time to recurrence group (P < 0.0001). Multivariate analysis of both cohorts demonstrated surgery for recurrent GBM was independently significant after adjusting for age, Karnofsky Performance Scale, and time to tumor recurrence (P < 0.0001).Surgery for recurrent GBM leads to improved survival independent of age, Karnofsky Performance Scale, and time to tumor recurrence. Patients with time to tumor recurrence >6 months benefit most from additional surgery." @default.
- W4286511497 created "2022-07-22" @default.
- W4286511497 creator A5009342117 @default.
- W4286511497 creator A5019043638 @default.
- W4286511497 creator A5055946870 @default.
- W4286511497 creator A5072584423 @default.
- W4286511497 date "2022-10-01" @default.
- W4286511497 modified "2023-09-30" @default.
- W4286511497 title "Surgery for Recurrent Glioblastoma Multiforme: A Retrospective Case Control Study" @default.
- W4286511497 cites W1860764269 @default.
- W4286511497 cites W1881534971 @default.
- W4286511497 cites W2040283668 @default.
- W4286511497 cites W2110265246 @default.
- W4286511497 cites W2169590480 @default.
- W4286511497 cites W2266410811 @default.
- W4286511497 cites W2436534309 @default.
- W4286511497 cites W2490921156 @default.
- W4286511497 cites W2611762350 @default.
- W4286511497 cites W2918212993 @default.
- W4286511497 cites W2922687256 @default.
- W4286511497 cites W2964869047 @default.
- W4286511497 cites W2982426240 @default.
- W4286511497 cites W3092373574 @default.
- W4286511497 cites W3176048796 @default.
- W4286511497 doi "https://doi.org/10.1016/j.wneu.2022.07.070" @default.
- W4286511497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35870781" @default.
- W4286511497 hasPublicationYear "2022" @default.
- W4286511497 type Work @default.
- W4286511497 citedByCount "1" @default.
- W4286511497 countsByYear W42865114972023 @default.
- W4286511497 crossrefType "journal-article" @default.
- W4286511497 hasAuthorship W4286511497A5009342117 @default.
- W4286511497 hasAuthorship W4286511497A5019043638 @default.
- W4286511497 hasAuthorship W4286511497A5055946870 @default.
- W4286511497 hasAuthorship W4286511497A5072584423 @default.
- W4286511497 hasConcept C126322002 @default.
- W4286511497 hasConcept C141071460 @default.
- W4286511497 hasConcept C167135981 @default.
- W4286511497 hasConcept C2776194525 @default.
- W4286511497 hasConcept C2779134260 @default.
- W4286511497 hasConcept C38180746 @default.
- W4286511497 hasConcept C502942594 @default.
- W4286511497 hasConcept C71924100 @default.
- W4286511497 hasConcept C72563966 @default.
- W4286511497 hasConceptScore W4286511497C126322002 @default.
- W4286511497 hasConceptScore W4286511497C141071460 @default.
- W4286511497 hasConceptScore W4286511497C167135981 @default.
- W4286511497 hasConceptScore W4286511497C2776194525 @default.
- W4286511497 hasConceptScore W4286511497C2779134260 @default.
- W4286511497 hasConceptScore W4286511497C38180746 @default.
- W4286511497 hasConceptScore W4286511497C502942594 @default.
- W4286511497 hasConceptScore W4286511497C71924100 @default.
- W4286511497 hasConceptScore W4286511497C72563966 @default.
- W4286511497 hasLocation W42865114971 @default.
- W4286511497 hasLocation W42865114972 @default.
- W4286511497 hasOpenAccess W4286511497 @default.
- W4286511497 hasPrimaryLocation W42865114971 @default.
- W4286511497 hasRelatedWork W2002120878 @default.
- W4286511497 hasRelatedWork W2003938723 @default.
- W4286511497 hasRelatedWork W2047967234 @default.
- W4286511497 hasRelatedWork W2099768740 @default.
- W4286511497 hasRelatedWork W2118496982 @default.
- W4286511497 hasRelatedWork W2439875401 @default.
- W4286511497 hasRelatedWork W2606371609 @default.
- W4286511497 hasRelatedWork W4238867864 @default.
- W4286511497 hasRelatedWork W4320724410 @default.
- W4286511497 hasRelatedWork W2525756941 @default.
- W4286511497 hasVolume "166" @default.
- W4286511497 isParatext "false" @default.
- W4286511497 isRetracted "false" @default.
- W4286511497 workType "article" @default.