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- W4286511907 endingPage "213036" @default.
- W4286511907 startingPage "213036" @default.
- W4286511907 abstract "The dialogue between host macrophages (Mφs) and endogenous mesenchymal stem cells (MSCs) promotes M2 Mφs polarization to resolve early-stage inflammation, thereby effectively guiding in situ bone regeneration. Once inflammation is unresolved/incontrollable, it will induce the impediment of MSCs homing at bone defect site, implying the seasonable resolution of inflammation in balancing bone homeostasis. Repeatedly, evidence elucidated that specialized pro-resolving mediators (SPMs) could conduce to proper resolve inflammation and promote the repairing of bone defect. A difunctional demineralized bone matrix (DBM) scaffold co-modified by maresin 1 (MaR1) and aptamer 19S (Apt19S) was fabricated to facilitate the osteogenesis of MSCs. To confirm the osteogenesis and immunomodulatory role of the difunctional DBM scaffold, the proliferation, recruitment, and osteogenic differentiation of MSCs and the Mφs M2 subtype polarization were evaluated in vitro. Then, the DBM scaffolds were implanted into mice model with critical size calvarial defect to evaluate bone repair efficiency. Finally, the specific resolution mechanism in Mφs cultured on the difunctional DBM scaffold was further in-depth investigated. This difunctional DBM scaffold exhibited an enhanced function on the recruitment, proliferation, migration, osteogenesis of MSCs and the resolution of inflammation, finally improved bone-scaffold integration. At the same time, MaR1 modified on the difunctional DBM scaffold increased the biosynthesis of 12-lipoxygenase (12-LOX) and 12S-hydroxy-eicosatetraenoic acid (12S-HETE), and also directly stimulated lipid droplets (LDs) biogenesis in Mφs, which suggested that MaR1 regulated Mφ lipid metabolism at bone repair site. Findings based on this synergy strategy demonstrated that Mφ lipid metabolism was essential in bone homeostasis, which might provide a theoretical direction for the treatment-associated application of MaR1 in inflammatory bone disease." @default.
- W4286511907 created "2022-07-22" @default.
- W4286511907 creator A5045854308 @default.
- W4286511907 creator A5082827291 @default.
- W4286511907 date "2022-08-01" @default.
- W4286511907 modified "2023-10-05" @default.
- W4286511907 title "A cell-free difunctional demineralized bone matrix scaffold enhances the recruitment and osteogenesis of mesenchymal stem cells by promoting inflammation resolution" @default.
- W4286511907 cites W1505047300 @default.
- W4286511907 cites W1529732941 @default.
- W4286511907 cites W1535815464 @default.
- W4286511907 cites W1562310953 @default.
- W4286511907 cites W1670356458 @default.
- W4286511907 cites W1779095282 @default.
- W4286511907 cites W1964033571 @default.
- W4286511907 cites W1967693339 @default.
- W4286511907 cites W1978134672 @default.
- W4286511907 cites W1984685797 @default.
- W4286511907 cites W1996485697 @default.
- W4286511907 cites W2003968006 @default.
- W4286511907 cites W2017335731 @default.
- W4286511907 cites W2017636893 @default.
- W4286511907 cites W2039684640 @default.
- W4286511907 cites W2045654913 @default.
- W4286511907 cites W2049478866 @default.
- W4286511907 cites W2054250836 @default.
- W4286511907 cites W2057237423 @default.
- W4286511907 cites W2073883364 @default.
- W4286511907 cites W2076898547 @default.
- W4286511907 cites W2090609282 @default.
- W4286511907 cites W2122405246 @default.
- W4286511907 cites W2125555008 @default.
- W4286511907 cites W2132182857 @default.
- W4286511907 cites W2134236498 @default.
- W4286511907 cites W2147263332 @default.
- W4286511907 cites W2162465757 @default.
- W4286511907 cites W2168513234 @default.
- W4286511907 cites W2214439439 @default.
- W4286511907 cites W2252287206 @default.
- W4286511907 cites W2284643044 @default.
- W4286511907 cites W2290548509 @default.
- W4286511907 cites W2417191518 @default.
- W4286511907 cites W2520957155 @default.
- W4286511907 cites W2524211206 @default.
- W4286511907 cites W2547703783 @default.
- W4286511907 cites W2587360484 @default.
- W4286511907 cites W2593091324 @default.
- W4286511907 cites W2604848467 @default.
- W4286511907 cites W2736400110 @default.
- W4286511907 cites W2737893453 @default.
- W4286511907 cites W2760815328 @default.
- W4286511907 cites W2767429780 @default.
- W4286511907 cites W2800101210 @default.
- W4286511907 cites W2800441622 @default.
- W4286511907 cites W2802357699 @default.
- W4286511907 cites W2804680715 @default.
- W4286511907 cites W2807670328 @default.
- W4286511907 cites W2813411201 @default.
- W4286511907 cites W2885214828 @default.
- W4286511907 cites W2887215933 @default.
- W4286511907 cites W2897962060 @default.
- W4286511907 cites W2906997838 @default.
- W4286511907 cites W2911225507 @default.
- W4286511907 cites W2911667875 @default.
- W4286511907 cites W2919279492 @default.
- W4286511907 cites W2921132259 @default.
- W4286511907 cites W2930099870 @default.
- W4286511907 cites W2945412194 @default.
- W4286511907 cites W2945703177 @default.
- W4286511907 cites W2982895754 @default.
- W4286511907 cites W2990005654 @default.
- W4286511907 cites W3005155384 @default.
- W4286511907 cites W3005941992 @default.
- W4286511907 cites W3022445007 @default.
- W4286511907 cites W3049766578 @default.
- W4286511907 cites W3084786401 @default.
- W4286511907 cites W3089315332 @default.
- W4286511907 cites W3091956344 @default.
- W4286511907 cites W3092030063 @default.
- W4286511907 cites W3093010709 @default.
- W4286511907 cites W3134029010 @default.
- W4286511907 cites W3157420813 @default.
- W4286511907 cites W3159938043 @default.
- W4286511907 cites W3167760186 @default.
- W4286511907 cites W3189138355 @default.
- W4286511907 cites W3192898797 @default.
- W4286511907 doi "https://doi.org/10.1016/j.bioadv.2022.213036" @default.
- W4286511907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35905556" @default.
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