FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286512444> ?p ?o ?g. }

• W4286512444 endingPage "213041" @default.
• W4286512444 startingPage "213041" @default.
• W4286512444 abstract "Tissue engineering with human cardiac fibroblasts (CF) allows identifying novel mechanisms and anti-fibrotic drugs in the context of cardiac fibrosis. However, substantial knowledge on the influences of the used materials and tissue geometries on tissue properties and cell phenotypes is necessary to be able to choose an appropriate model for a specific research question. As there is a clear lack of information on how CF react to the mold architecture in engineered connective tissues (ECT), we first compared the effect of two mold geometries and materials with different hardnesses on the biomechanical properties of ECT. We could show that ECT, which formed around two distant poles (non-uniform model) were less stiff and more strain-resistant than ECT, which formed around a central rod (uniform model), independent of the materials used for poles and rods. Next, we investigated the cell state and could demonstrate that in the uniform versus non-uniform model, the embedded cells have a higher cell cycle activity and display a more pronounced myofibroblast phenotype. Differential gene expression analysis revealed that uniform ECT displayed a fibrosis-associated gene signature similar to the diseased heart. Furthermore, we were able to identify important relationships between cell and tissue characteristics, as well as between biomechanical tissue parameters by implementing cells from normal heart and end-stage heart failure explants from patients with ischemic or dilated cardiomyopathy. Finally, we show that the application of pro- and anti-fibrotic factors in the non-uniform and uniform model, respectively, is not sufficient to mimic the effect of the other geometry. Taken together, we demonstrate that modifying the mold geometry in tissue engineering with CF offers the possibility to compare different cellular phenotypes and biomechanical tissue properties." @default.
• W4286512444 created "2022-07-22" @default.
• W4286512444 creator A5005975685 @default.
• W4286512444 creator A5010686800 @default.
• W4286512444 creator A5031530341 @default.
• W4286512444 creator A5040619925 @default.
• W4286512444 creator A5050135589 @default.
• W4286512444 creator A5050249160 @default.
• W4286512444 creator A5054336885 @default.
• W4286512444 creator A5063477512 @default.
• W4286512444 creator A5072077160 @default.
• W4286512444 creator A5072903340 @default.
• W4286512444 creator A5073087480 @default.
• W4286512444 date "2022-08-01" @default.
• W4286512444 modified "2023-10-16" @default.
• W4286512444 title "Using different geometries to modulate the cardiac fibroblast phenotype and the biomechanical properties of engineered connective tissues" @default.
• W4286512444 cites W1617495083 @default.
• W4286512444 cites W1946469214 @default.
• W4286512444 cites W1972449305 @default.
• W4286512444 cites W1972782439 @default.
• W4286512444 cites W1974848384 @default.
• W4286512444 cites W1976572971 @default.
• W4286512444 cites W1984514301 @default.
• W4286512444 cites W1989277387 @default.
• W4286512444 cites W1993415261 @default.
• W4286512444 cites W1997906188 @default.
• W4286512444 cites W2006812487 @default.
• W4286512444 cites W2007759711 @default.
• W4286512444 cites W2023692320 @default.
• W4286512444 cites W2027274753 @default.
• W4286512444 cites W2030014267 @default.
• W4286512444 cites W2043731345 @default.
• W4286512444 cites W2045949302 @default.
• W4286512444 cites W2053677311 @default.
• W4286512444 cites W2063907039 @default.
• W4286512444 cites W2086368972 @default.
• W4286512444 cites W2086670943 @default.
• W4286512444 cites W2105050893 @default.
• W4286512444 cites W2118692920 @default.
• W4286512444 cites W2138207763 @default.
• W4286512444 cites W2140057975 @default.
• W4286512444 cites W2158217645 @default.
• W4286512444 cites W2162514162 @default.
• W4286512444 cites W2168139605 @default.
• W4286512444 cites W2169456326 @default.
• W4286512444 cites W2175892199 @default.
• W4286512444 cites W2179438025 @default.
• W4286512444 cites W2272318470 @default.
• W4286512444 cites W2318892216 @default.
• W4286512444 cites W2345376732 @default.
• W4286512444 cites W2482213414 @default.
• W4286512444 cites W2530928249 @default.
• W4286512444 cites W2587079466 @default.
• W4286512444 cites W2604927641 @default.
• W4286512444 cites W2615881490 @default.
• W4286512444 cites W2747169980 @default.
• W4286512444 cites W2750808153 @default.
• W4286512444 cites W2768398928 @default.
• W4286512444 cites W2789397833 @default.
• W4286512444 cites W2800350399 @default.
• W4286512444 cites W2802903441 @default.
• W4286512444 cites W2804064570 @default.
• W4286512444 cites W2804825996 @default.
• W4286512444 cites W2806131394 @default.
• W4286512444 cites W2871148319 @default.
• W4286512444 cites W2884514580 @default.
• W4286512444 cites W2900044275 @default.
• W4286512444 cites W2900569176 @default.
• W4286512444 cites W2909389152 @default.
• W4286512444 cites W2913263558 @default.
• W4286512444 cites W2924188812 @default.
• W4286512444 cites W2934133090 @default.
• W4286512444 cites W2950025421 @default.
• W4286512444 cites W2955275838 @default.
• W4286512444 cites W2999995689 @default.
• W4286512444 cites W3003178444 @default.
• W4286512444 cites W3007723686 @default.
• W4286512444 cites W3086997047 @default.
• W4286512444 cites W3088401235 @default.
• W4286512444 cites W3147690167 @default.
• W4286512444 cites W3158485841 @default.
• W4286512444 cites W3202571733 @default.
• W4286512444 cites W3210718651 @default.
• W4286512444 cites W4205101740 @default.
• W4286512444 cites W4225082671 @default.
• W4286512444 doi "https://doi.org/10.1016/j.bioadv.2022.213041" @default.
• W4286512444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35909053" @default.
• W4286512444 hasPublicationYear "2022" @default.
• W4286512444 type Work @default.
• W4286512444 citedByCount "2" @default.
• W4286512444 countsByYear W42865124442023 @default.
• W4286512444 crossrefType "journal-article" @default.
• W4286512444 hasAuthorship W4286512444A5005975685 @default.
• W4286512444 hasAuthorship W4286512444A5010686800 @default.
• W4286512444 hasAuthorship W4286512444A5031530341 @default.
• W4286512444 hasAuthorship W4286512444A5040619925 @default.
• W4286512444 hasAuthorship W4286512444A5050135589 @default.
• W4286512444 hasAuthorship W4286512444A5050249160 @default.

• next