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- W4286512860 abstract "RNA localization and biomolecular condensate formation are key biological strategies for organizing the cytoplasm and generating cellular polarity. In Xenopus oocytes, RNAs required for germ layer patterning localize in biomolecular condensates, termed Localization bodies (L-bodies). Here, we have used an L-body RNA-binding protein, PTBP3, to test the role of RNA-protein interactions in regulating the biophysical characteristics of L-bodies in vivo and PTBP3-RNA condensates in vitro. Our results reveal that RNA-protein interactions drive recruitment of PTBP3 and localized RNA to L-bodies and that multivalent interactions tune the dynamics of the PTBP3 after localization. In a concentration-dependent manner, RNA becomes non-dynamic and interactions with the RNA determine PTBP3 dynamics within these biomolecular condensates in vivo and in vitro. Importantly, RNA, and not protein, is required for maintenance of the PTBP3-RNA condensates in vitro, pointing to a model where RNA serves as a non-dynamic substructure in these condensates." @default.
- W4286512860 created "2022-07-22" @default.
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- W4286512860 date "2022-08-01" @default.
- W4286512860 modified "2023-09-27" @default.
- W4286512860 title "Multivalent interactions with RNA drive recruitment and dynamics in biomolecular condensates in Xenopus oocytes" @default.
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- W4286512860 doi "https://doi.org/10.1016/j.isci.2022.104811" @default.
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