Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286559675> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4286559675 endingPage "512" @default.
- W4286559675 startingPage "507" @default.
- W4286559675 abstract "Small interfering RNAs (siRNAs) with N-acetylgalactosamine (GalNAc) conjugation for improved liver uptake represent an emerging class of drugs to treat liver diseases. Understanding how pharmacokinetics and pharmacodynamics translate is pivotal for in vivo study design and human dose prediction. However, the literature is sparse on translational data for this modality, and pharmacokinetics in the liver is seldom measured. To overcome these difficulties, we collected time-course biomarker data for 11 GalNAc–siRNAs in various species and applied the kinetic-pharmacodynamic modeling approach to estimate the biophase (liver) half-life and the potency. Our analysis indicates that the biophase half-life is 0.6–3 weeks in mouse, 1–8 weeks in monkey, and 1.5–14 weeks in human. For individual siRNAs, the biophase half-life is 1–8 times longer in human than in mouse, and generally 1–3 times longer in human than in monkey. The analysis indicates that the siRNAs are more potent in human than in mouse and monkey." @default.
- W4286559675 created "2022-07-22" @default.
- W4286559675 creator A5002506738 @default.
- W4286559675 creator A5018809376 @default.
- W4286559675 creator A5019093073 @default.
- W4286559675 creator A5076779683 @default.
- W4286559675 creator A5081380130 @default.
- W4286559675 date "2022-12-01" @default.
- W4286559675 modified "2023-10-01" @default.
- W4286559675 title "Cross-Species Translation of Biophase Half-Life and Potency of GalNAc-Conjugated siRNAs" @default.
- W4286559675 cites W2027319450 @default.
- W4286559675 cites W2073909589 @default.
- W4286559675 cites W2322913813 @default.
- W4286559675 cites W2568306867 @default.
- W4286559675 cites W2595169180 @default.
- W4286559675 cites W2734498030 @default.
- W4286559675 cites W2896199800 @default.
- W4286559675 cites W2911904102 @default.
- W4286559675 cites W2944262545 @default.
- W4286559675 cites W3037874297 @default.
- W4286559675 cites W3092190815 @default.
- W4286559675 cites W3108615218 @default.
- W4286559675 cites W3121560287 @default.
- W4286559675 cites W3137153690 @default.
- W4286559675 cites W3146237634 @default.
- W4286559675 cites W3157259886 @default.
- W4286559675 cites W3161865957 @default.
- W4286559675 cites W3174704442 @default.
- W4286559675 cites W4206591430 @default.
- W4286559675 cites W620005749 @default.
- W4286559675 doi "https://doi.org/10.1089/nat.2022.0010" @default.
- W4286559675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35867041" @default.
- W4286559675 hasPublicationYear "2022" @default.
- W4286559675 type Work @default.
- W4286559675 citedByCount "1" @default.
- W4286559675 countsByYear W42865596752023 @default.
- W4286559675 crossrefType "journal-article" @default.
- W4286559675 hasAuthorship W4286559675A5002506738 @default.
- W4286559675 hasAuthorship W4286559675A5018809376 @default.
- W4286559675 hasAuthorship W4286559675A5019093073 @default.
- W4286559675 hasAuthorship W4286559675A5076779683 @default.
- W4286559675 hasAuthorship W4286559675A5081380130 @default.
- W4286559675 hasBestOaLocation W42865596751 @default.
- W4286559675 hasConcept C104317684 @default.
- W4286559675 hasConcept C111113717 @default.
- W4286559675 hasConcept C112705442 @default.
- W4286559675 hasConcept C185592680 @default.
- W4286559675 hasConcept C202751555 @default.
- W4286559675 hasConcept C207001950 @default.
- W4286559675 hasConcept C22615655 @default.
- W4286559675 hasConcept C2776418720 @default.
- W4286559675 hasConcept C54355233 @default.
- W4286559675 hasConcept C55493867 @default.
- W4286559675 hasConcept C57992300 @default.
- W4286559675 hasConcept C67705224 @default.
- W4286559675 hasConcept C71924100 @default.
- W4286559675 hasConcept C86803240 @default.
- W4286559675 hasConcept C98274493 @default.
- W4286559675 hasConceptScore W4286559675C104317684 @default.
- W4286559675 hasConceptScore W4286559675C111113717 @default.
- W4286559675 hasConceptScore W4286559675C112705442 @default.
- W4286559675 hasConceptScore W4286559675C185592680 @default.
- W4286559675 hasConceptScore W4286559675C202751555 @default.
- W4286559675 hasConceptScore W4286559675C207001950 @default.
- W4286559675 hasConceptScore W4286559675C22615655 @default.
- W4286559675 hasConceptScore W4286559675C2776418720 @default.
- W4286559675 hasConceptScore W4286559675C54355233 @default.
- W4286559675 hasConceptScore W4286559675C55493867 @default.
- W4286559675 hasConceptScore W4286559675C57992300 @default.
- W4286559675 hasConceptScore W4286559675C67705224 @default.
- W4286559675 hasConceptScore W4286559675C71924100 @default.
- W4286559675 hasConceptScore W4286559675C86803240 @default.
- W4286559675 hasConceptScore W4286559675C98274493 @default.
- W4286559675 hasIssue "6" @default.
- W4286559675 hasLocation W42865596751 @default.
- W4286559675 hasLocation W42865596752 @default.
- W4286559675 hasLocation W42865596753 @default.
- W4286559675 hasLocation W42865596754 @default.
- W4286559675 hasOpenAccess W4286559675 @default.
- W4286559675 hasPrimaryLocation W42865596751 @default.
- W4286559675 hasRelatedWork W1998587742 @default.
- W4286559675 hasRelatedWork W2004556784 @default.
- W4286559675 hasRelatedWork W2010793381 @default.
- W4286559675 hasRelatedWork W2227061539 @default.
- W4286559675 hasRelatedWork W2254638634 @default.
- W4286559675 hasRelatedWork W2388069209 @default.
- W4286559675 hasRelatedWork W2582907174 @default.
- W4286559675 hasRelatedWork W2753834235 @default.
- W4286559675 hasRelatedWork W2953758866 @default.
- W4286559675 hasRelatedWork W2992709639 @default.
- W4286559675 hasVolume "32" @default.
- W4286559675 isParatext "false" @default.
- W4286559675 isRetracted "false" @default.
- W4286559675 workType "article" @default.