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- W4286560322 abstract "Regulation of cell signaling cascades is critical in making sure the response is activated spatially and for a desired duration. Cell signaling cascades are spatially and temporally controlled through local protein phosphorylation events which are determined by the activation of specific kinases and/or inactivation of phosphatases to elicit a complete and thorough response. For example, A-kinase-anchoring proteins (AKAPs) contribute to the local regulated activity protein kinase A (PKA). The activity of kinases and phosphatases can also be regulated through redox-dependent cysteine modifications that mediate the activity of these proteins. A primary example of this is the activation of the epidermal growth factor receptor (EGFR) and the inactivation of the phosphatase and tensin homologue (PTEN) phosphatase by reactive oxygen species (ROS). Therefore, the local redox environment must play a critical role in the timing and magnitude of these events. Mitochondria are a primary source of ROS and energy (ATP) that contributes to redox-dependent signaling and ATP-dependent phosphorylation events, respectively. The strategic positioning of mitochondria within cells contributes to intracellular gradients of ROS and ATP, which have been shown to correlate with changes to protein redox and phosphorylation status driving downstream cellular processes. In this review, we will discuss the relationship between subcellular mitochondrial positioning and intracellular ROS and ATP gradients that support dynamic oxidation and phosphorylation signaling and resulting cellular effects, specifically associated with cell migration signaling." @default.
- W4286560322 created "2022-07-22" @default.
- W4286560322 creator A5013832766 @default.
- W4286560322 creator A5084624529 @default.
- W4286560322 creator A5085980410 @default.
- W4286560322 date "2022-07-22" @default.
- W4286560322 modified "2023-09-30" @default.
- W4286560322 title "Mitochondrial trafficking and redox/phosphorylation signaling supporting cell migration phenotypes" @default.
- W4286560322 cites W124607863 @default.
- W4286560322 cites W1522866349 @default.
- W4286560322 cites W1523213544 @default.
- W4286560322 cites W1535283655 @default.
- W4286560322 cites W1579500241 @default.
- W4286560322 cites W1592859877 @default.
- W4286560322 cites W1604877879 @default.
- W4286560322 cites W1747138696 @default.
- W4286560322 cites W1802829593 @default.
- W4286560322 cites W1965498876 @default.
- W4286560322 cites W1969360388 @default.
- W4286560322 cites W1970302092 @default.
- W4286560322 cites W1973063454 @default.
- W4286560322 cites W1974214519 @default.
- W4286560322 cites W1975084717 @default.
- W4286560322 cites W1978880986 @default.
- W4286560322 cites W1979127230 @default.
- W4286560322 cites W1986124091 @default.
- W4286560322 cites W1987334422 @default.
- W4286560322 cites W1991878174 @default.
- W4286560322 cites W1995565650 @default.
- W4286560322 cites W2007636933 @default.
- W4286560322 cites W2008656776 @default.
- W4286560322 cites W2011575800 @default.
- W4286560322 cites W2012713600 @default.
- W4286560322 cites W2017233644 @default.
- W4286560322 cites W2020272282 @default.
- W4286560322 cites W2020453318 @default.
- W4286560322 cites W2024558090 @default.
- W4286560322 cites W2026772781 @default.
- W4286560322 cites W2029195231 @default.
- W4286560322 cites W2034716886 @default.
- W4286560322 cites W2036760275 @default.
- W4286560322 cites W2038394514 @default.
- W4286560322 cites W2042041984 @default.
- W4286560322 cites W2042552693 @default.
- W4286560322 cites W2043549608 @default.
- W4286560322 cites W2046616002 @default.
- W4286560322 cites W2050897300 @default.
- W4286560322 cites W2053697597 @default.
- W4286560322 cites W2056351479 @default.
- W4286560322 cites W2061237420 @default.
- W4286560322 cites W2069463594 @default.
- W4286560322 cites W2070143299 @default.
- W4286560322 cites W2077284342 @default.
- W4286560322 cites W2081301114 @default.
- W4286560322 cites W2087680897 @default.
- W4286560322 cites W2089044757 @default.
- W4286560322 cites W2093279875 @default.
- W4286560322 cites W2096499490 @default.
- W4286560322 cites W2102411854 @default.
- W4286560322 cites W2112546324 @default.
- W4286560322 cites W2113714326 @default.
- W4286560322 cites W2115470184 @default.
- W4286560322 cites W2117424780 @default.
- W4286560322 cites W2117962961 @default.
- W4286560322 cites W2118738797 @default.
- W4286560322 cites W2121113385 @default.
- W4286560322 cites W2121317746 @default.
- W4286560322 cites W2122341467 @default.
- W4286560322 cites W2123603473 @default.
- W4286560322 cites W2130254666 @default.
- W4286560322 cites W2134724797 @default.
- W4286560322 cites W2135110724 @default.
- W4286560322 cites W2135314348 @default.
- W4286560322 cites W2135841986 @default.
- W4286560322 cites W2142015620 @default.
- W4286560322 cites W2148332345 @default.
- W4286560322 cites W2148703449 @default.
- W4286560322 cites W2151924608 @default.
- W4286560322 cites W2152718807 @default.
- W4286560322 cites W2159765576 @default.
- W4286560322 cites W2162633290 @default.
- W4286560322 cites W2164444293 @default.
- W4286560322 cites W2165601218 @default.
- W4286560322 cites W2166499489 @default.
- W4286560322 cites W2167872299 @default.
- W4286560322 cites W2168750058 @default.
- W4286560322 cites W2169818209 @default.
- W4286560322 cites W2170591186 @default.
- W4286560322 cites W2171065062 @default.
- W4286560322 cites W2269336718 @default.
- W4286560322 cites W2317877264 @default.
- W4286560322 cites W2341537044 @default.
- W4286560322 cites W2342179630 @default.
- W4286560322 cites W2461913882 @default.
- W4286560322 cites W2522503981 @default.
- W4286560322 cites W2611851783 @default.
- W4286560322 cites W2613273453 @default.
- W4286560322 cites W2622794576 @default.
- W4286560322 cites W2725773065 @default.
- W4286560322 cites W2734745767 @default.