FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286560912> ?p ?o ?g. }

• W4286560912 abstract "In both diurnal and nocturnal mammals, the timing of activity is regulated by the central circadian clock of the suprachiasmatic nucleus (SCN). The SCN is synchronized to the external light cycle via the retinohypothalamic tract (RHT). To investigate potential differences in light processing between nocturnal mice and the diurnal rodent Rhabdomys pumilio, we mimicked retinal input by stimulation of the RHT ex vivo. Using Ca2+ imaging, we observed excitations as well as inhibitions of SCN neurons in response to electrical RHT stimulation. In mice, the vast majority of responses were excitatory (85%), whereas in Rhabdomys, the proportion of excitatory and inhibitory responses was similar (51% excitatory, 49% inhibitory). Glutamate blockers AP5 and CNQX blocked the excitatory responses to RHT stimulation but did not abolish the inhibitory responses in mice or Rhabdomys, indicating that the inhibitions were monosynaptically transmitted via the RHT. Simultaneous application of glutamate blockers with the GABAA antagonist gabazine blocked all inhibitory responses in mice, but not in Rhabdomys. Collectively, our results indicate that in Rhabdomys, considerably more inhibitory responses to light are present and that these responses are driven directly by the RHT. We propose that this increased proportion of inhibitory input could reflect a difference in the entrainment mechanism employed by diurnal rodents." @default.
• W4286560912 created "2022-07-22" @default.
• W4286560912 creator A5004262821 @default.
• W4286560912 creator A5020160452 @default.
• W4286560912 creator A5029752148 @default.
• W4286560912 creator A5045235800 @default.
• W4286560912 creator A5050757957 @default.
• W4286560912 creator A5062352766 @default.
• W4286560912 creator A5066128766 @default.
• W4286560912 creator A5083022369 @default.
• W4286560912 date "2022-07-22" @default.
• W4286560912 modified "2023-10-18" @default.
• W4286560912 title "Inhibitory responses to retinohypothalamic tract stimulation in the circadian clock of the diurnal rodent <i>Rhabdomys pumilio</i>" @default.
• W4286560912 cites W1496968249 @default.
• W4286560912 cites W1538299079 @default.
• W4286560912 cites W1906704471 @default.
• W4286560912 cites W1968779417 @default.
• W4286560912 cites W1979948609 @default.
• W4286560912 cites W1996569207 @default.
• W4286560912 cites W2018437467 @default.
• W4286560912 cites W2019394392 @default.
• W4286560912 cites W2020551161 @default.
• W4286560912 cites W2027029625 @default.
• W4286560912 cites W2028963652 @default.
• W4286560912 cites W2034098043 @default.
• W4286560912 cites W2040495168 @default.
• W4286560912 cites W2041124882 @default.
• W4286560912 cites W2047678578 @default.
• W4286560912 cites W2054936731 @default.
• W4286560912 cites W2055273697 @default.
• W4286560912 cites W2063976426 @default.
• W4286560912 cites W2078689239 @default.
• W4286560912 cites W2088459975 @default.
• W4286560912 cites W2093986158 @default.
• W4286560912 cites W2094426488 @default.
• W4286560912 cites W2096235467 @default.
• W4286560912 cites W2116214322 @default.
• W4286560912 cites W2127617657 @default.
• W4286560912 cites W2129449621 @default.
• W4286560912 cites W2137252071 @default.
• W4286560912 cites W2149814646 @default.
• W4286560912 cites W2153042537 @default.
• W4286560912 cites W2157266711 @default.
• W4286560912 cites W2161711916 @default.
• W4286560912 cites W2162570080 @default.
• W4286560912 cites W2164000351 @default.
• W4286560912 cites W2413659530 @default.
• W4286560912 cites W2808964483 @default.
• W4286560912 cites W2892779344 @default.
• W4286560912 cites W2998412655 @default.
• W4286560912 cites W3022183975 @default.
• W4286560912 cites W3164743632 @default.
• W4286560912 cites W4220759139 @default.
• W4286560912 cites W4226484846 @default.
• W4286560912 cites W4286560912 @default.
• W4286560912 doi "https://doi.org/10.1096/fj.202200477r" @default.
• W4286560912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35867045" @default.
• W4286560912 hasPublicationYear "2022" @default.
• W4286560912 type Work @default.
• W4286560912 citedByCount "4" @default.
• W4286560912 countsByYear W42865609122022 @default.
• W4286560912 countsByYear W42865609122023 @default.
• W4286560912 crossrefType "journal-article" @default.
• W4286560912 hasAuthorship W4286560912A5004262821 @default.
• W4286560912 hasAuthorship W4286560912A5020160452 @default.
• W4286560912 hasAuthorship W4286560912A5029752148 @default.
• W4286560912 hasAuthorship W4286560912A5045235800 @default.
• W4286560912 hasAuthorship W4286560912A5050757957 @default.
• W4286560912 hasAuthorship W4286560912A5062352766 @default.
• W4286560912 hasAuthorship W4286560912A5066128766 @default.
• W4286560912 hasAuthorship W4286560912A5083022369 @default.
• W4286560912 hasBestOaLocation W42865609121 @default.
• W4286560912 hasConcept C112592302 @default.
• W4286560912 hasConcept C121446783 @default.
• W4286560912 hasConcept C169760540 @default.
• W4286560912 hasConcept C170493617 @default.
• W4286560912 hasConcept C17077164 @default.
• W4286560912 hasConcept C18903297 @default.
• W4286560912 hasConcept C24998067 @default.
• W4286560912 hasConcept C2777334680 @default.
• W4286560912 hasConcept C2779317972 @default.
• W4286560912 hasConcept C55493867 @default.
• W4286560912 hasConcept C61174792 @default.
• W4286560912 hasConcept C86803240 @default.
• W4286560912 hasConceptScore W4286560912C112592302 @default.
• W4286560912 hasConceptScore W4286560912C121446783 @default.
• W4286560912 hasConceptScore W4286560912C169760540 @default.
• W4286560912 hasConceptScore W4286560912C170493617 @default.
• W4286560912 hasConceptScore W4286560912C17077164 @default.
• W4286560912 hasConceptScore W4286560912C18903297 @default.
• W4286560912 hasConceptScore W4286560912C24998067 @default.
• W4286560912 hasConceptScore W4286560912C2777334680 @default.
• W4286560912 hasConceptScore W4286560912C2779317972 @default.
• W4286560912 hasConceptScore W4286560912C55493867 @default.
• W4286560912 hasConceptScore W4286560912C61174792 @default.
• W4286560912 hasConceptScore W4286560912C86803240 @default.
• W4286560912 hasFunder F4320309607 @default.
• W4286560912 hasFunder F4320338335 @default.
• W4286560912 hasIssue "8" @default.
• W4286560912 hasLocation W42865609121 @default.

• next