FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286561100> ?p ?o ?g. }

• W4286561100 abstract "Previous data have reported that Sentrin/SUMO-specific protease 6 (SENP6) is involved in ischaemic brain injury and induces neuronal apoptosis after cerebral ischaemia, but the role of SENP6 in microglia-induced neuroinflammation and its underlying mechanism remain poorly understood. This research systematically explored the function and potential mechanism of SENP6 in microglia-induced neuroinflammation after ischaemic stroke.We first identified an increased protein level of SENP6 in microglia after cerebral ischaemia. Then, we demonstrated that SENP6 promoted detrimental microglial phenotype polarization. Specifically, SENP6-mediated de-SUMOylation of ANXA1 targeted the IκB kinase (IKK) complex and selectively inhibited the autophagic degradation of IKKα in an NBR1-dependent manner, activating the NF-κB pathway and enhancing proinflammatory cytokine expression. In addition, downregulation of SENP6 in microglia effectively reduced cocultured neuronal damage induced by ischaemic stroke. More importantly, we employed an AAV-based technique to specifically knockdown SENP6 in microglia/macrophages, and in vivo experiments showed that SENP6 inhibition in microglia/macrophages notably lessened brain ischaemic infarct size, decreased neurological deficit scores, and ameliorated motor and cognitive function in mice subjected to cerebral ischaemia surgery.We demonstrated a previously unidentified mechanism by which SENP6-mediated ANXA1 de-SUMOylation regulates microglial polarization and our results strongly indicated that in microglia, inhibition of SENP6 may be a crucial beneficial therapeutic strategy for ischaemic stroke." @default.
• W4286561100 created "2022-07-22" @default.
• W4286561100 creator A5017673049 @default.
• W4286561100 creator A5040040812 @default.
• W4286561100 creator A5049641684 @default.
• W4286561100 creator A5080457276 @default.
• W4286561100 creator A5082921193 @default.
• W4286561100 creator A5083476226 @default.
• W4286561100 date "2022-07-22" @default.
• W4286561100 modified "2023-10-13" @default.
• W4286561100 title "SENP6 induces microglial polarization and neuroinflammation through de-SUMOylation of Annexin-A1 after cerebral ischaemia–reperfusion injury" @default.
• W4286561100 cites W2020483997 @default.
• W4286561100 cites W2020971467 @default.
• W4286561100 cites W2036093656 @default.
• W4286561100 cites W2043301115 @default.
• W4286561100 cites W2058478749 @default.
• W4286561100 cites W2092684977 @default.
• W4286561100 cites W2153406260 @default.
• W4286561100 cites W2262503792 @default.
• W4286561100 cites W2345329114 @default.
• W4286561100 cites W2412051656 @default.
• W4286561100 cites W2507282775 @default.
• W4286561100 cites W2586083640 @default.
• W4286561100 cites W2597003300 @default.
• W4286561100 cites W2672056725 @default.
• W4286561100 cites W2761635843 @default.
• W4286561100 cites W2782378867 @default.
• W4286561100 cites W2793014640 @default.
• W4286561100 cites W2803718019 @default.
• W4286561100 cites W2807660866 @default.
• W4286561100 cites W2883561311 @default.
• W4286561100 cites W2883717630 @default.
• W4286561100 cites W2884200530 @default.
• W4286561100 cites W2910894118 @default.
• W4286561100 cites W2919592499 @default.
• W4286561100 cites W2921112006 @default.
• W4286561100 cites W2980310498 @default.
• W4286561100 cites W2981785373 @default.
• W4286561100 cites W2982606752 @default.
• W4286561100 cites W2988739644 @default.
• W4286561100 cites W3000673912 @default.
• W4286561100 cites W3000967366 @default.
• W4286561100 cites W3005598595 @default.
• W4286561100 cites W3008348330 @default.
• W4286561100 cites W3008535867 @default.
• W4286561100 cites W3011586959 @default.
• W4286561100 cites W3093557230 @default.
• W4286561100 cites W3099956633 @default.
• W4286561100 cites W3117793992 @default.
• W4286561100 cites W3119238477 @default.
• W4286561100 cites W3121800029 @default.
• W4286561100 cites W3126089501 @default.
• W4286561100 cites W3159754177 @default.
• W4286561100 cites W3169269533 @default.
• W4286561100 cites W3215251945 @default.
• W4286561100 cites W4206436306 @default.
• W4286561100 cites W4220701931 @default.
• W4286561100 cites W4220724669 @default.
• W4286561100 doi "https://doi.org/10.1186/s13578-022-00850-2" @default.
• W4286561100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35869493" @default.
• W4286561100 hasPublicationYear "2022" @default.
• W4286561100 type Work @default.
• W4286561100 citedByCount "6" @default.
• W4286561100 countsByYear W42865611002023 @default.
• W4286561100 crossrefType "journal-article" @default.
• W4286561100 hasAuthorship W4286561100A5017673049 @default.
• W4286561100 hasAuthorship W4286561100A5040040812 @default.
• W4286561100 hasAuthorship W4286561100A5049641684 @default.
• W4286561100 hasAuthorship W4286561100A5080457276 @default.
• W4286561100 hasAuthorship W4286561100A5082921193 @default.
• W4286561100 hasAuthorship W4286561100A5083476226 @default.
• W4286561100 hasBestOaLocation W42865611001 @default.
• W4286561100 hasConcept C104317684 @default.
• W4286561100 hasConcept C126322002 @default.
• W4286561100 hasConcept C164027704 @default.
• W4286561100 hasConcept C169760540 @default.
• W4286561100 hasConcept C171350616 @default.
• W4286561100 hasConcept C173396325 @default.
• W4286561100 hasConcept C190283241 @default.
• W4286561100 hasConcept C203014093 @default.
• W4286561100 hasConcept C25498285 @default.
• W4286561100 hasConcept C25602115 @default.
• W4286561100 hasConcept C2776914184 @default.
• W4286561100 hasConcept C2779830541 @default.
• W4286561100 hasConcept C541997718 @default.
• W4286561100 hasConcept C55493867 @default.
• W4286561100 hasConcept C71924100 @default.
• W4286561100 hasConcept C86803240 @default.
• W4286561100 hasConcept C87753298 @default.
• W4286561100 hasConcept C95444343 @default.
• W4286561100 hasConcept C98274493 @default.
• W4286561100 hasConceptScore W4286561100C104317684 @default.
• W4286561100 hasConceptScore W4286561100C126322002 @default.
• W4286561100 hasConceptScore W4286561100C164027704 @default.
• W4286561100 hasConceptScore W4286561100C169760540 @default.
• W4286561100 hasConceptScore W4286561100C171350616 @default.
• W4286561100 hasConceptScore W4286561100C173396325 @default.
• W4286561100 hasConceptScore W4286561100C190283241 @default.
• W4286561100 hasConceptScore W4286561100C203014093 @default.
• W4286561100 hasConceptScore W4286561100C25498285 @default.

• next