Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286561769> ?p ?o ?g. }
- W4286561769 abstract "Abstract Alzheimer’s disease (AD) is a fatal cognitive disorder with proteinaceous brain deposits, neuroinflammation, cerebrovascular dysfunction, and extensive neuronal loss over time. AD is a multifactorial disease, and lifestyle factors, including diet, are likely associated with the development of AD pathology. Since obesity and diabetes are recognized as risk factors for AD, it might be predicted that a high-fat diet (HFD) would worsen AD pathology. However, modeling HFD-induced obesity in AD animal models has yielded inconclusive results. Some studies report a deleterious effect of HFD on Aβ accumulation, neuroinflammation, and cognitive function, while others report that HFD worsens memory without affecting AD brain pathology. Moreover, several studies report no major effect of HFD on AD-related phenotypes in mice, while other studies show that HFD might, in fact, be protective. The lack of a clear association between dietary fat consumption and AD-related pathology and cognitive function in AD mouse models might be explained by experimental variations, including AD mouse model, sex and age of the animals, composition of the HFD, and timeline of HFD consumption. In this review, we summarize recent studies that aimed at elucidating the effect of HFD-induced obesity on AD-related pathology in mice and provide an overview of the factors that may have contributed to the results reported in these studies. Based on the heterogeneity of these animal model studies and given that the human population itself is quite disparate, it is likely that people will benefit most from individualized nutritional plans based on their medical history and clinical profiles." @default.
- W4286561769 created "2022-07-22" @default.
- W4286561769 creator A5009847380 @default.
- W4286561769 creator A5046709096 @default.
- W4286561769 creator A5081666339 @default.
- W4286561769 date "2022-07-22" @default.
- W4286561769 modified "2023-10-07" @default.
- W4286561769 title "The effect of dietary fat consumption on Alzheimer’s disease pathogenesis in mouse models" @default.
- W4286561769 cites W1483245362 @default.
- W4286561769 cites W1503258737 @default.
- W4286561769 cites W1503895697 @default.
- W4286561769 cites W1524376662 @default.
- W4286561769 cites W1555936968 @default.
- W4286561769 cites W186149320 @default.
- W4286561769 cites W1929267935 @default.
- W4286561769 cites W1967464880 @default.
- W4286561769 cites W1968531410 @default.
- W4286561769 cites W1970812394 @default.
- W4286561769 cites W1973276273 @default.
- W4286561769 cites W1975015501 @default.
- W4286561769 cites W1983924380 @default.
- W4286561769 cites W1984737558 @default.
- W4286561769 cites W1994083528 @default.
- W4286561769 cites W1995344309 @default.
- W4286561769 cites W2001210466 @default.
- W4286561769 cites W2008992496 @default.
- W4286561769 cites W2011885704 @default.
- W4286561769 cites W2013101568 @default.
- W4286561769 cites W2017581860 @default.
- W4286561769 cites W2028545299 @default.
- W4286561769 cites W2034354239 @default.
- W4286561769 cites W2041851050 @default.
- W4286561769 cites W2042794149 @default.
- W4286561769 cites W2053288363 @default.
- W4286561769 cites W2064694967 @default.
- W4286561769 cites W2066630911 @default.
- W4286561769 cites W2074676675 @default.
- W4286561769 cites W2090586279 @default.
- W4286561769 cites W2090620788 @default.
- W4286561769 cites W2096166726 @default.
- W4286561769 cites W2105155954 @default.
- W4286561769 cites W2109958697 @default.
- W4286561769 cites W2154212660 @default.
- W4286561769 cites W2156788921 @default.
- W4286561769 cites W2170644095 @default.
- W4286561769 cites W2239265781 @default.
- W4286561769 cites W2294215996 @default.
- W4286561769 cites W2348647453 @default.
- W4286561769 cites W2407468727 @default.
- W4286561769 cites W2420952677 @default.
- W4286561769 cites W2472186754 @default.
- W4286561769 cites W2531578777 @default.
- W4286561769 cites W2561241607 @default.
- W4286561769 cites W2563078526 @default.
- W4286561769 cites W2576073432 @default.
- W4286561769 cites W2686471536 @default.
- W4286561769 cites W2751577610 @default.
- W4286561769 cites W2763508344 @default.
- W4286561769 cites W2769568841 @default.
- W4286561769 cites W2782982995 @default.
- W4286561769 cites W2790911786 @default.
- W4286561769 cites W2886846674 @default.
- W4286561769 cites W2901046251 @default.
- W4286561769 cites W2902887888 @default.
- W4286561769 cites W2943992542 @default.
- W4286561769 cites W2958230138 @default.
- W4286561769 cites W2964584195 @default.
- W4286561769 cites W2975453802 @default.
- W4286561769 cites W2976687323 @default.
- W4286561769 cites W3005458426 @default.
- W4286561769 cites W3007464392 @default.
- W4286561769 cites W3015399495 @default.
- W4286561769 cites W3035923503 @default.
- W4286561769 cites W3045787305 @default.
- W4286561769 cites W3090628550 @default.
- W4286561769 cites W3090955472 @default.
- W4286561769 cites W3113152292 @default.
- W4286561769 cites W3152399208 @default.
- W4286561769 cites W3164808835 @default.
- W4286561769 cites W3165707786 @default.
- W4286561769 cites W3178684518 @default.
- W4286561769 cites W4210821588 @default.
- W4286561769 cites W4211238543 @default.
- W4286561769 cites W4238608606 @default.
- W4286561769 cites W44915015 @default.
- W4286561769 doi "https://doi.org/10.1038/s41398-022-02067-w" @default.
- W4286561769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35869065" @default.
- W4286561769 hasPublicationYear "2022" @default.
- W4286561769 type Work @default.
- W4286561769 citedByCount "5" @default.
- W4286561769 countsByYear W42865617692023 @default.
- W4286561769 crossrefType "journal-article" @default.
- W4286561769 hasAuthorship W4286561769A5009847380 @default.
- W4286561769 hasAuthorship W4286561769A5046709096 @default.
- W4286561769 hasAuthorship W4286561769A5081666339 @default.
- W4286561769 hasBestOaLocation W42865617691 @default.
- W4286561769 hasConcept C118552586 @default.
- W4286561769 hasConcept C126322002 @default.
- W4286561769 hasConcept C15744967 @default.
- W4286561769 hasConcept C169760540 @default.