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- W4286564648 abstract "Traumatic brain injury (TBI) is known to impair synaptic function, and subsequently contribute to observed cognitive deficits. Retinoic Acid (RA) signaling modulates expression of synaptic plasticity proteins and is involved in hippocampal learning and memory. All trans-retinoic acid (ATRA), a metabolite of Vitamin A, has been identified as a potential pharmacotherapeutic for other neurological disorders due to this role. This study conducted an ATRA dose response to determine its therapeutic effects on cognitive behaviors and expression of hippocampal markers of synaptic plasticity and RA signaling proteins after experimental TBI. Under isoflurane anesthesia, adult male Sprague Dawley rats received either controlled cortical impact (CCI, 2.5 mm deformation, 4 m/s) or control surgery. Animals received daily intraperitoneal injection of 0.5, 1, 5, or 10 mg/kg of ATRA or vehicle for 2 weeks. Animals underwent motor and spatial learning and memory testing. Hippocampal expression of synaptic plasticity proteins neurogranin (Ng), and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 sub-unit, as well as RA signaling proteins STRA6, ADLH1a1, CYP26A1 and CYP26B1 were evaluated by western blot at 2-weeks post-injury. ATRA treatment significantly recovered Ng synaptic protein expression, while having no effect on motor performance, spatial learning, and memory, and GluA1 expression after TBI. RA signaling protein expression is unchanged 2 weeks after TBI. Overall, ATRA administration after TBI showed limited therapeutic benefits compared to the vehicle." @default.
- W4286564648 created "2022-07-22" @default.
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- W4286564648 date "2022-09-01" @default.
- W4286564648 modified "2023-10-18" @default.
- W4286564648 title "All-trans Retinoic Acid has Limited Therapeutic Effects on Cognition and Hippocampal Protein Expression After Controlled Cortical Impact" @default.
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- W4286564648 cites W1919133853 @default.
- W4286564648 cites W1923767489 @default.
- W4286564648 cites W1964169664 @default.
- W4286564648 cites W1966316797 @default.
- W4286564648 cites W1969112847 @default.
- W4286564648 cites W1969968664 @default.
- W4286564648 cites W1973719910 @default.
- W4286564648 cites W1978628739 @default.
- W4286564648 cites W1979056400 @default.
- W4286564648 cites W1980420209 @default.
- W4286564648 cites W1981278455 @default.
- W4286564648 cites W1983759041 @default.
- W4286564648 cites W1985796926 @default.
- W4286564648 cites W1989824843 @default.
- W4286564648 cites W1993119799 @default.
- W4286564648 cites W1994819066 @default.
- W4286564648 cites W1997435185 @default.
- W4286564648 cites W1998905522 @default.
- W4286564648 cites W1999170657 @default.
- W4286564648 cites W2005311714 @default.
- W4286564648 cites W2014567150 @default.
- W4286564648 cites W2015122191 @default.
- W4286564648 cites W2019794759 @default.
- W4286564648 cites W2021330953 @default.
- W4286564648 cites W2022474992 @default.
- W4286564648 cites W2025011598 @default.
- W4286564648 cites W2027575557 @default.
- W4286564648 cites W2034671678 @default.
- W4286564648 cites W2038111587 @default.
- W4286564648 cites W2041165019 @default.
- W4286564648 cites W2042313154 @default.
- W4286564648 cites W2043999797 @default.
- W4286564648 cites W2050519369 @default.
- W4286564648 cites W2054013982 @default.
- W4286564648 cites W2057774514 @default.
- W4286564648 cites W2060901333 @default.
- W4286564648 cites W2062090669 @default.
- W4286564648 cites W2067629356 @default.
- W4286564648 cites W2076013820 @default.
- W4286564648 cites W2083267691 @default.
- W4286564648 cites W2084817972 @default.
- W4286564648 cites W2089531918 @default.
- W4286564648 cites W2090571205 @default.
- W4286564648 cites W2094188444 @default.
- W4286564648 cites W2094628771 @default.
- W4286564648 cites W2096181156 @default.
- W4286564648 cites W2116871842 @default.
- W4286564648 cites W2125577585 @default.
- W4286564648 cites W2148096341 @default.
- W4286564648 cites W2161262899 @default.
- W4286564648 cites W2167916157 @default.
- W4286564648 cites W2196629482 @default.
- W4286564648 cites W2201282324 @default.
- W4286564648 cites W2358610562 @default.
- W4286564648 cites W2528514032 @default.
- W4286564648 cites W2594920035 @default.
- W4286564648 cites W2604861321 @default.
- W4286564648 cites W2762839102 @default.
- W4286564648 cites W2763815330 @default.
- W4286564648 cites W2792893657 @default.
- W4286564648 cites W2801231655 @default.
- W4286564648 cites W2804028881 @default.
- W4286564648 cites W2889651885 @default.
- W4286564648 cites W2947536369 @default.
- W4286564648 cites W2970660635 @default.
- W4286564648 cites W2975389431 @default.
- W4286564648 cites W2989241662 @default.
- W4286564648 cites W3027168795 @default.
- W4286564648 cites W3084372857 @default.
- W4286564648 cites W3088354352 @default.
- W4286564648 cites W310871232 @default.
- W4286564648 cites W3153496315 @default.
- W4286564648 cites W3194151968 @default.
- W4286564648 cites W3195119857 @default.
- W4286564648 cites W4220862725 @default.
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- W4286564648 doi "https://doi.org/10.1016/j.neuroscience.2022.07.021" @default.
- W4286564648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35878718" @default.
- W4286564648 hasPublicationYear "2022" @default.
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