FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286566360> ?p ?o ?g. }

• W4286566360 endingPage "109080" @default.
• W4286566360 startingPage "109080" @default.
• W4286566360 abstract "Uveitis is an intraocular inflammatory disease. Epigenetics has been associated with its pathogenesis. However, the role of N6-methyladenosine (m6A) in uveitis has not been reported. We aimed to examine the role of m6A and its regulatory mechanism in experimental autoimmune uveitis (EAU).The mRNA expression of m6A-related methylase and demethylase of retinal pigment epithelium (RPE) between mice with EAU and control mice was detected by RT-qPCR. The overall m6A level of ARPE-19 cells was detected by an m6A quantitative detection kit. Cell proliferation was observed by CCK-8 assays, and ELISA was used to test the secretion of inflammatory factors. The expression of tight junction proteins and the target genes of FTO were examined by western blotting and MeRIP-PCR.A decreased expression of FTO in RPE cells was found in mice with EAU. Increased overall m6A%, proliferation of cells and secretion of IL-6, IL-8 and MCP-1 were found after FTO knockdown in ARPE-19 cells. However, ZO-1 and occludin protein expression was decreased. ATF4 protein expression was decreased in the FTO knockdown (shFTO) group as compared with the control (shNC) group. In contrast, the m6A level of ATF4 was elevated, as shown by MeRIP-PCR. Functional analysis showed that p-STAT3 expression was increased in the shFTO group, and the change in occludin expression was reversed in ATF4 rescue experiment.FTO may affect the translation of ATF4 by regulating its m6A level, resulting in the increased expression of p-STAT3 and inflammatory factors, and leading to uveitis." @default.
• W4286566360 created "2022-07-22" @default.
• W4286566360 creator A5018118883 @default.
• W4286566360 creator A5022770789 @default.
• W4286566360 creator A5031315906 @default.
• W4286566360 creator A5036936453 @default.
• W4286566360 creator A5055294970 @default.
• W4286566360 creator A5075802444 @default.
• W4286566360 creator A5077348149 @default.
• W4286566360 date "2022-08-01" @default.
• W4286566360 modified "2023-10-13" @default.
• W4286566360 title "N6-methyladenosine demethylase FTO regulates inflammatory cytokine secretion and tight junctions in retinal pigment epithelium cells" @default.
• W4286566360 cites W1895681508 @default.
• W4286566360 cites W1952415318 @default.
• W4286566360 cites W1981629946 @default.
• W4286566360 cites W2015853744 @default.
• W4286566360 cites W2020826725 @default.
• W4286566360 cites W2032952316 @default.
• W4286566360 cites W2041036769 @default.
• W4286566360 cites W2049275241 @default.
• W4286566360 cites W2065847836 @default.
• W4286566360 cites W2071930821 @default.
• W4286566360 cites W2074471441 @default.
• W4286566360 cites W2153312133 @default.
• W4286566360 cites W2175514210 @default.
• W4286566360 cites W2563912688 @default.
• W4286566360 cites W2588330711 @default.
• W4286566360 cites W2589225545 @default.
• W4286566360 cites W2618870156 @default.
• W4286566360 cites W2743522323 @default.
• W4286566360 cites W2751668414 @default.
• W4286566360 cites W2777271597 @default.
• W4286566360 cites W2782419892 @default.
• W4286566360 cites W2787351196 @default.
• W4286566360 cites W2805506311 @default.
• W4286566360 cites W2883541825 @default.
• W4286566360 cites W2901016862 @default.
• W4286566360 cites W2901633430 @default.
• W4286566360 cites W2911349862 @default.
• W4286566360 cites W2921030200 @default.
• W4286566360 cites W2964951435 @default.
• W4286566360 cites W2979744254 @default.
• W4286566360 cites W2993470268 @default.
• W4286566360 cites W2997171616 @default.
• W4286566360 cites W3001876083 @default.
• W4286566360 cites W3015190397 @default.
• W4286566360 cites W3022065712 @default.
• W4286566360 cites W3025403854 @default.
• W4286566360 cites W3036083442 @default.
• W4286566360 cites W3046723694 @default.
• W4286566360 cites W3080195180 @default.
• W4286566360 cites W3083820674 @default.
• W4286566360 cites W3087125681 @default.
• W4286566360 cites W3093077098 @default.
• W4286566360 cites W3095499599 @default.
• W4286566360 cites W3110112315 @default.
• W4286566360 cites W3136908109 @default.
• W4286566360 cites W3140944384 @default.
• W4286566360 cites W3143787191 @default.
• W4286566360 cites W3185635035 @default.
• W4286566360 cites W4200581080 @default.
• W4286566360 cites W4239469316 @default.
• W4286566360 cites W4286494943 @default.
• W4286566360 doi "https://doi.org/10.1016/j.clim.2022.109080" @default.
• W4286566360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35878734" @default.
• W4286566360 hasPublicationYear "2022" @default.
• W4286566360 type Work @default.
• W4286566360 citedByCount "11" @default.
• W4286566360 countsByYear W42865663602022 @default.
• W4286566360 countsByYear W42865663602023 @default.
• W4286566360 crossrefType "journal-article" @default.
• W4286566360 hasAuthorship W4286566360A5018118883 @default.
• W4286566360 hasAuthorship W4286566360A5022770789 @default.
• W4286566360 hasAuthorship W4286566360A5031315906 @default.
• W4286566360 hasAuthorship W4286566360A5036936453 @default.
• W4286566360 hasAuthorship W4286566360A5055294970 @default.
• W4286566360 hasAuthorship W4286566360A5075802444 @default.
• W4286566360 hasAuthorship W4286566360A5077348149 @default.
• W4286566360 hasConcept C104317684 @default.
• W4286566360 hasConcept C134018914 @default.
• W4286566360 hasConcept C153911025 @default.
• W4286566360 hasConcept C173396325 @default.
• W4286566360 hasConcept C177779419 @default.
• W4286566360 hasConcept C185592680 @default.
• W4286566360 hasConcept C190283241 @default.
• W4286566360 hasConcept C2775962179 @default.
• W4286566360 hasConcept C2778024200 @default.
• W4286566360 hasConcept C2780827179 @default.
• W4286566360 hasConcept C2781364455 @default.
• W4286566360 hasConcept C41091548 @default.
• W4286566360 hasConcept C49039625 @default.
• W4286566360 hasConcept C55493867 @default.
• W4286566360 hasConcept C86803240 @default.
• W4286566360 hasConcept C95444343 @default.
• W4286566360 hasConceptScore W4286566360C104317684 @default.
• W4286566360 hasConceptScore W4286566360C134018914 @default.
• W4286566360 hasConceptScore W4286566360C153911025 @default.
• W4286566360 hasConceptScore W4286566360C173396325 @default.

• next