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- W4286566596 endingPage "166459" @default.
- W4286566596 startingPage "166459" @default.
- W4286566596 abstract "Magnetic iron oxide nanoclusters (IONCs) are the secondary structure consisting of multiple single primary magnetic iron oxide nanoparticles (IONPs), which significantly enhance the magnetic response of the entire material due to synergistic magnetism, while retaining the superparamagnetic characteristics in the meantime and avoid agglomeration caused by residual magnetization. IONCs provide versatile platforms and opportunities due to their unique magnetic property and biosafety for biomedical applications such as magnetic resonance imaging (MRI), magnetic particle imaging (MPI), immunodetection, drug delivery and hyperthermia. These techniques rely on external stimuli-responsiveness of materials, such as the generation of local fields and dynamic response to external fields. To pursue ultimate performance, precisely controlled doping engineering of IONCs is desired for tailoring their physical and chemical properties in biomedical applications. Therefore, this review outlines the design considerations and implications of magnetic nanoclusters in the above-mentioned applications. It focuses on the recent progress in the doping engineering of IONCs and their biomedical applications in vitro and in vivo. It further discusses the functionalization and the related biological responses of metal-doped IONCs. The doping strategy and sources for functionalizing IONCs will be provided to facilitate ongoing research in multifunctional biomedical applications." @default.
- W4286566596 created "2022-07-22" @default.
- W4286566596 creator A5032407442 @default.
- W4286566596 creator A5063835503 @default.
- W4286566596 creator A5072282231 @default.
- W4286566596 creator A5073983312 @default.
- W4286566596 creator A5082252890 @default.
- W4286566596 date "2022-11-01" @default.
- W4286566596 modified "2023-10-18" @default.
- W4286566596 title "Doping engineering and functionalization of iron oxide nanoclusters for biomedical applications" @default.
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