FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286567100> ?p ?o ?g. }

• W4286567100 endingPage "121987" @default.
• W4286567100 startingPage "121987" @default.
• W4286567100 abstract "The co-formulation of glyburide (Gly) and vanillic acid (VA) as such in the form of nanomedicine has never been explored to treat metabolic diseases including type 2 diabetes mellitus. Both the drugs possess dissolution rate-limited oral bioavailability leading to poor therapeutic efficacy. Hence, co-loading these drugs into a nanocarrier could overcome their poor oral bioavailability related challenges. Owing to this objective, both drugs were co-loaded in amphiphilic polymeric micelles (APMs) and evaluated for their biopharmaceutical outcomes. The APMs were prepared using mPEG-b-PCL/CTAB as a copolymer-surfactant system via the liquid antisolvent precipitation (LAP) method. The design of these APMs were optimized using Box Behnken Design by taking various process/formulation based variables to achieve the desired micellar traits. The release of both the drugs from the optimized co-loaded APMs was compared in different media and displayed a remarkable sustained release profile owing to their hydrophobic interactions with the PCL core. The in vitro cytotoxicity study of co-loaded APMs on Caco-2 cells revealed 70 % cell viability in a concentration-dependent manner. The preventive effects of Gly and VA co-loaded in APMs on glucose uptake was studied in insulin-responsive human HepG2 cells treated with high glucose. The co-loading of both the drugs in optimized APMs exhibited synergistic glucose-lowering activity (p < 0.001) than raw drugs with low cytotoxicity on HepG2 cells within the test concentration. This could be attributed to an increase in the relative oral bioavailability of both the drugs in APMs i.e., 868 % for Gly and 87 % for VA respectively." @default.
• W4286567100 created "2022-07-22" @default.
• W4286567100 creator A5004543087 @default.
• W4286567100 creator A5007749446 @default.
• W4286567100 creator A5008834153 @default.
• W4286567100 creator A5009150583 @default.
• W4286567100 creator A5010367903 @default.
• W4286567100 creator A5014511927 @default.
• W4286567100 creator A5023533610 @default.
• W4286567100 creator A5024165513 @default.
• W4286567100 creator A5035358791 @default.
• W4286567100 creator A5039829599 @default.
• W4286567100 creator A5040015789 @default.
• W4286567100 creator A5044372095 @default.
• W4286567100 creator A5055121728 @default.
• W4286567100 creator A5063798252 @default.
• W4286567100 creator A5073251236 @default.
• W4286567100 creator A5075936988 @default.
• W4286567100 creator A5076219083 @default.
• W4286567100 creator A5086600671 @default.
• W4286567100 date "2022-08-01" @default.
• W4286567100 modified "2023-10-15" @default.
• W4286567100 title "Polymeric micelles loaded with glyburide and vanillic acid: I. Formulation development, in-vitro characterization and bioavailability studies" @default.
• W4286567100 cites W1971982726 @default.
• W4286567100 cites W1997156967 @default.
• W4286567100 cites W1999481657 @default.
• W4286567100 cites W2002419343 @default.
• W4286567100 cites W2005477647 @default.
• W4286567100 cites W2017422800 @default.
• W4286567100 cites W2026314563 @default.
• W4286567100 cites W2027542963 @default.
• W4286567100 cites W2061955697 @default.
• W4286567100 cites W2078369917 @default.
• W4286567100 cites W2079229392 @default.
• W4286567100 cites W2084562674 @default.
• W4286567100 cites W2087193946 @default.
• W4286567100 cites W2128597180 @default.
• W4286567100 cites W2142229269 @default.
• W4286567100 cites W2156011368 @default.
• W4286567100 cites W2187119809 @default.
• W4286567100 cites W2188207707 @default.
• W4286567100 cites W2516639854 @default.
• W4286567100 cites W2610485393 @default.
• W4286567100 cites W2617905968 @default.
• W4286567100 cites W2794594041 @default.
• W4286567100 cites W2806432392 @default.
• W4286567100 cites W2811076426 @default.
• W4286567100 cites W2890661934 @default.
• W4286567100 cites W2900478661 @default.
• W4286567100 cites W2996602442 @default.
• W4286567100 cites W3035486616 @default.
• W4286567100 cites W3154370106 @default.
• W4286567100 cites W3155873373 @default.
• W4286567100 cites W4211259434 @default.
• W4286567100 cites W4212895951 @default.
• W4286567100 cites W956454888 @default.
• W4286567100 doi "https://doi.org/10.1016/j.ijpharm.2022.121987" @default.
• W4286567100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35878873" @default.
• W4286567100 hasPublicationYear "2022" @default.
• W4286567100 type Work @default.
• W4286567100 citedByCount "10" @default.
• W4286567100 countsByYear W42865671002022 @default.
• W4286567100 countsByYear W42865671002023 @default.
• W4286567100 crossrefType "journal-article" @default.
• W4286567100 hasAuthorship W4286567100A5004543087 @default.
• W4286567100 hasAuthorship W4286567100A5007749446 @default.
• W4286567100 hasAuthorship W4286567100A5008834153 @default.
• W4286567100 hasAuthorship W4286567100A5009150583 @default.
• W4286567100 hasAuthorship W4286567100A5010367903 @default.
• W4286567100 hasAuthorship W4286567100A5014511927 @default.
• W4286567100 hasAuthorship W4286567100A5023533610 @default.
• W4286567100 hasAuthorship W4286567100A5024165513 @default.
• W4286567100 hasAuthorship W4286567100A5035358791 @default.
• W4286567100 hasAuthorship W4286567100A5039829599 @default.
• W4286567100 hasAuthorship W4286567100A5040015789 @default.
• W4286567100 hasAuthorship W4286567100A5044372095 @default.
• W4286567100 hasAuthorship W4286567100A5055121728 @default.
• W4286567100 hasAuthorship W4286567100A5063798252 @default.
• W4286567100 hasAuthorship W4286567100A5073251236 @default.
• W4286567100 hasAuthorship W4286567100A5075936988 @default.
• W4286567100 hasAuthorship W4286567100A5076219083 @default.
• W4286567100 hasAuthorship W4286567100A5086600671 @default.
• W4286567100 hasConcept C109316439 @default.
• W4286567100 hasConcept C11268172 @default.
• W4286567100 hasConcept C150903083 @default.
• W4286567100 hasConcept C178790620 @default.
• W4286567100 hasConcept C181389837 @default.
• W4286567100 hasConcept C18150654 @default.
• W4286567100 hasConcept C184651966 @default.
• W4286567100 hasConcept C185592680 @default.
• W4286567100 hasConcept C202751555 @default.
• W4286567100 hasConcept C2776549161 @default.
• W4286567100 hasConcept C2780035454 @default.
• W4286567100 hasConcept C2781047461 @default.
• W4286567100 hasConcept C43617362 @default.
• W4286567100 hasConcept C55493867 @default.
• W4286567100 hasConcept C58226133 @default.
• W4286567100 hasConcept C71924100 @default.

• next