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- W4286586322 abstract "The rapidly emerging phenomenon of antibiotic resistance threatens to substantially reduce the efficacy of available antibacterial therapies. Dissemination of resistance, even between phylogenetically distant bacterial species, is mediated mainly by mobile genetic elements, considered to be natural vectors of horizontal gene transfer. Transposable elements (TEs) play a major role in this process-due to their highly recombinogenic nature they can mobilize adjacent genes and can introduce them into the pool of mobile DNA. Studies investigating this phenomenon usually focus on the genetic load of transposons and the molecular basis of their mobility. However, genes introduced into evolutionarily distant hosts are not necessarily expressed. As a result, bacterial genomes contain a reservoir of transcriptionally silent genetic information that can be activated by various transposon-related recombination events. The TEs themselves along with processes associated with their transposition can introduce promoters into random genomic locations. Thus, similarly to integrons, they have the potential to convert dormant genes into fully functional antibiotic resistance determinants. In this review, we describe the genetic basis of such events and by extension the mechanisms promoting the emergence of new drug-resistant bacterial strains." @default.
- W4286586322 created "2022-07-22" @default.
- W4286586322 creator A5004300803 @default.
- W4286586322 creator A5052214171 @default.
- W4286586322 creator A5091776493 @default.
- W4286586322 date "2022-07-22" @default.
- W4286586322 modified "2023-10-05" @default.
- W4286586322 title "How Do Transposable Elements Activate Expression of Transcriptionally Silent Antibiotic Resistance Genes?" @default.
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