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- W4286586327 abstract "Abstract Background: Vitamin D is synthesized in the skin or supplied. Cholecalciferol is hydroxylated in the liver to 25(OH) vitamin D [25D]. 25D is further hydroxylated in the kidney to 1,25(OH) vitamin D [1,25D]. Catabolism occurs by further hydroxylation. Magnesium is a cofactor of all involved hydroxylases. Aim: To investigate the association between serum levels of 1,25D and serum magnesium concentrations, and renal function. Method: Laboratory values measured in an outpatient cohort over 2 years were analysed. Results: Renal function and magnesium level did not influence 25D values. Mean serum 1,25D values decreased from 106.5 ± 44.3 pmol/l in individuals with normal renal function to 51.7 ± 18.9 pmol/l in those with severe renal insufficiency (p<0.01). A weak positive correlation was observed between 1,25D and eGFR (r=0.317), and between 1,25D and serum magnesium (r=0.217). Conclusion: Impaired renal function and low magnesium serum levels are slightly associated with low 1,25D concentrations. Measuring 25D, but not 1,25D, may overestimate the patient’s vitamin D status. In patients with renal insufficiency adequate magnesium supply should be ensured." @default.
- W4286586327 created "2022-07-22" @default.
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- W4286586327 date "2022-07-22" @default.
- W4286586327 modified "2023-09-27" @default.
- W4286586327 title "Renal insufficiency and magnesium deficiency hinder the formation of biologically active cholecalciferol" @default.
- W4286586327 doi "https://doi.org/10.21203/rs.3.rs-1859477/v1" @default.
- W4286586327 hasPublicationYear "2022" @default.
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