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- W4286586775 endingPage "3571" @default.
- W4286586775 startingPage "3571" @default.
- W4286586775 abstract "Tumor Budding (TB) represents a single cancer cell or a small cluster of less than five cancer cells on the infiltrative tumor front. Accumulating evidence suggests TB is an independent prognostic factor in oral squamous cell carcinoma (OSCC). However, its exact role is not yet elucidated, and a standardized scoring system is still necessary. The study aims to extensively review the literature data regarding the prognostic role of TB in OSCC. The results of TB are an independent prognostic factor of poor survival outcomes in OSCC. To date, the manual detection of hematoxylin and eosin-staining or pancytokeratin-immunostaining sections are the most commonly used methods. Between the several cut-offs, the two-tier system with five buds/field cut-offs provides better risk stratification. The prognostic role of the BD model in predicting survival outcomes was extensively validated; however, the inclusion of DOI, which is already a staging parameter, encouraged other authors to propose other models, integrating TB count with other adverse risk factors, such as the tumor–stroma ratio and tumor-infiltrated lymphocytes. The prognostic relevance of TB in OSCC highlights its evaluation in daily pathological practice. Therefore, the TB detection method and the TB scoring system should be validated based on tumor stage and site." @default.
- W4286586775 created "2022-07-22" @default.
- W4286586775 creator A5016503997 @default.
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- W4286586775 date "2022-07-22" @default.
- W4286586775 modified "2023-09-29" @default.
- W4286586775 title "The Emerging Impact of Tumor Budding in Oral Squamous Cell Carcinoma: Main Issues and Clinical Relevance of a New Prognostic Marker" @default.
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- W4286586775 doi "https://doi.org/10.3390/cancers14153571" @default.
- W4286586775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35892830" @default.
- W4286586775 hasPublicationYear "2022" @default.