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- W4286587139 abstract "Epidemiological and experimental evidence recognize a relationship between sleep-wake cycles and adiposity levels, but the mechanisms that link both are not entirely understood. Adipose tissue secretes adiponectin and leptin hormones, mainly involved as indicators of adiposity levels and recently associated to sleep. To understand how two of the main adipose tissue hormones could influence sleep-wake regulation, we evaluated in male rats, the effect of direct administration of adiponectin or leptin in the ventrolateral preoptic nuclei (VLPO), a major area for sleep promotion. The presence of adiponectin (AdipoR1 and AdipoR2) and leptin receptors in VLPO were confirmed by immunohistochemistry. Adiponectin administration increased wakefulness during the rest phase, reduced delta power, and activated wake-promoting neurons, such as the locus coeruleus (LC), tuberomammillary nucleus (TMN) and hypocretin/orexin neurons (OX) within the lateral hypothalamus (LH) and perifornical area (PeF). Conversely, leptin promoted REM and NREM sleep, including increase of delta power during NREM sleep, and induced c-Fos expression in VLPO and melanin concentrating hormone expressing neurons (MCH). In addition, a reduction in wake-promoting neurons activity was found in the TMN, lateral hypothalamus (LH) and perifornical area (PeF), including in the OX neurons. Moreover, leptin administration reduced tyrosine hydroxylase (TH) immunoreactivity in the LC. Our data suggest that adiponectin and leptin act as hormonal mediators between the status of body energy and the regulation of the sleep-wake cycle." @default.
- W4286587139 created "2022-07-22" @default.
- W4286587139 creator A5005452676 @default.
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- W4286587139 creator A5085845396 @default.
- W4286587139 date "2022-07-22" @default.
- W4286587139 modified "2023-10-16" @default.
- W4286587139 title "Leptin and adiponectin regulate the activity of nuclei involved in sleep-wake cycle in male rats" @default.
- W4286587139 cites W1509096603 @default.
- W4286587139 cites W1513674275 @default.
- W4286587139 cites W1513719789 @default.
- W4286587139 cites W1537253812 @default.
- W4286587139 cites W1591122824 @default.
- W4286587139 cites W1611501527 @default.
- W4286587139 cites W1612453552 @default.
- W4286587139 cites W1895384166 @default.
- W4286587139 cites W1964014715 @default.
- W4286587139 cites W1976458121 @default.
- W4286587139 cites W1985827032 @default.
- W4286587139 cites W1986838819 @default.
- W4286587139 cites W1988003558 @default.
- W4286587139 cites W1989621413 @default.
- W4286587139 cites W2000913774 @default.
- W4286587139 cites W2006068102 @default.
- W4286587139 cites W2006945340 @default.
- W4286587139 cites W2014345877 @default.
- W4286587139 cites W2015214863 @default.
- W4286587139 cites W2016011459 @default.
- W4286587139 cites W2017054186 @default.
- W4286587139 cites W2017132921 @default.
- W4286587139 cites W2018360208 @default.
- W4286587139 cites W2026178749 @default.
- W4286587139 cites W2027437492 @default.
- W4286587139 cites W2029544683 @default.
- W4286587139 cites W2031463153 @default.
- W4286587139 cites W2033100201 @default.
- W4286587139 cites W2035666331 @default.
- W4286587139 cites W2038008568 @default.
- W4286587139 cites W2038312320 @default.
- W4286587139 cites W2040330546 @default.
- W4286587139 cites W2044712116 @default.
- W4286587139 cites W2046908130 @default.
- W4286587139 cites W2049173726 @default.
- W4286587139 cites W2057554134 @default.
- W4286587139 cites W2058185026 @default.
- W4286587139 cites W2060138288 @default.
- W4286587139 cites W2064442671 @default.
- W4286587139 cites W2065273349 @default.
- W4286587139 cites W2066561594 @default.
- W4286587139 cites W2067132822 @default.
- W4286587139 cites W2076310317 @default.
- W4286587139 cites W2080680751 @default.
- W4286587139 cites W2081393100 @default.
- W4286587139 cites W2085510141 @default.
- W4286587139 cites W2089339596 @default.
- W4286587139 cites W2091934134 @default.
- W4286587139 cites W2092950426 @default.
- W4286587139 cites W2093876680 @default.
- W4286587139 cites W2094615493 @default.
- W4286587139 cites W2101664081 @default.
- W4286587139 cites W2109898272 @default.
- W4286587139 cites W2113087631 @default.
- W4286587139 cites W2113836851 @default.
- W4286587139 cites W2115505164 @default.
- W4286587139 cites W2115754884 @default.
- W4286587139 cites W2124544973 @default.
- W4286587139 cites W2124953491 @default.
- W4286587139 cites W2127207059 @default.
- W4286587139 cites W2128267059 @default.
- W4286587139 cites W2128485668 @default.
- W4286587139 cites W2129632024 @default.
- W4286587139 cites W2130357926 @default.
- W4286587139 cites W2133991442 @default.
- W4286587139 cites W2136189569 @default.
- W4286587139 cites W2136864883 @default.
- W4286587139 cites W2138330700 @default.
- W4286587139 cites W2149295638 @default.
- W4286587139 cites W2152003280 @default.
- W4286587139 cites W2155866679 @default.
- W4286587139 cites W2160610924 @default.
- W4286587139 cites W2167382671 @default.
- W4286587139 cites W2171610265 @default.
- W4286587139 cites W2213043300 @default.
- W4286587139 cites W2253911195 @default.
- W4286587139 cites W2283961973 @default.
- W4286587139 cites W2346066638 @default.
- W4286587139 cites W2361659253 @default.
- W4286587139 cites W2398584588 @default.
- W4286587139 cites W2419540537 @default.
- W4286587139 cites W2471663974 @default.
- W4286587139 cites W2512823779 @default.
- W4286587139 cites W2514190534 @default.
- W4286587139 cites W2516335543 @default.
- W4286587139 cites W2526118136 @default.