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- W4286587583 startingPage "3563" @default.
- W4286587583 abstract "Gut microbiota can have opposing functions from pro-tumorigenic to anti-tumorigenic effects. Increasing preclinical and clinical evidence suggests that the intestinal microbiota affects cancer patients' response to immune checkpoint inhibitors (ICIs) immunotherapy, such as anti-programmed cell death protein 1 (PD-1) and its ligand (PD-L1) and anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4). Microbiota-induced inflammation possibly contributes to tumor growth and cancer development. Microbiota-derived metabolites can also be converted to carcinogenic agents related to genetic mutations and DNA damage in organs such as the colon. However, other attributes of microbiota, such as greater diversity and specific bacterial species and their metabolites, are linked to better clinical outcomes and potentially improved anti-tumor immunity. In addition, the intratumoral microbial composition strongly affects T-cell-mediated cytotoxicity and anti-tumor immune surveillance, adding more complexity to the cancer-microbiome-immune axis. Despite the emerging clinical evidence for the activity of the gut microbiota in immuno-oncology, the fundamental mechanisms of such activity are not well understood. This review provides an overview of underlying mechanisms by which the gut microbiota and its metabolites enhance or suppress anti-tumor immune responses. Understanding such mechanisms allows for better design of microbiome-specific treatment strategies to improve the clinical outcome in cancer patients undergoing systemic therapy." @default.
- W4286587583 created "2022-07-22" @default.
- W4286587583 creator A5053773479 @default.
- W4286587583 creator A5084060241 @default.
- W4286587583 date "2022-07-22" @default.
- W4286587583 modified "2023-09-30" @default.
- W4286587583 title "The Effect of the Gut Microbiota on Systemic and Anti-Tumor Immunity and Response to Systemic Therapy against Cancer" @default.
- W4286587583 cites W143136217 @default.
- W4286587583 cites W1431584087 @default.
- W4286587583 cites W1487955035 @default.
- W4286587583 cites W1513574675 @default.
- W4286587583 cites W1618337835 @default.
- W4286587583 cites W1967821667 @default.
- W4286587583 cites W1975605578 @default.
- W4286587583 cites W1985964328 @default.
- W4286587583 cites W1990515033 @default.
- W4286587583 cites W2004774344 @default.
- W4286587583 cites W2010125549 @default.
- W4286587583 cites W2034082915 @default.
- W4286587583 cites W2034706392 @default.
- W4286587583 cites W2039907390 @default.
- W4286587583 cites W2041053955 @default.
- W4286587583 cites W2055703363 @default.
- W4286587583 cites W2056433310 @default.
- W4286587583 cites W2058362335 @default.
- W4286587583 cites W2067003464 @default.
- W4286587583 cites W2072417345 @default.
- W4286587583 cites W2075121741 @default.
- W4286587583 cites W2084659308 @default.
- W4286587583 cites W2089246633 @default.
- W4286587583 cites W2097875133 @default.
- W4286587583 cites W2098005365 @default.
- W4286587583 cites W2098793175 @default.
- W4286587583 cites W2103561589 @default.
- W4286587583 cites W2104885590 @default.
- W4286587583 cites W2107369528 @default.
- W4286587583 cites W2110389012 @default.
- W4286587583 cites W2125826054 @default.
- W4286587583 cites W2150735608 @default.
- W4286587583 cites W2157570303 @default.
- W4286587583 cites W2166691283 @default.
- W4286587583 cites W2188593832 @default.
- W4286587583 cites W2192215408 @default.
- W4286587583 cites W2257914719 @default.
- W4286587583 cites W2260426525 @default.
- W4286587583 cites W2263759961 @default.
- W4286587583 cites W2275606382 @default.
- W4286587583 cites W2278335898 @default.
- W4286587583 cites W2317340981 @default.
- W4286587583 cites W2335996377 @default.
- W4286587583 cites W2338446464 @default.
- W4286587583 cites W2401857311 @default.
- W4286587583 cites W2436511965 @default.
- W4286587583 cites W2508233001 @default.
- W4286587583 cites W2523298690 @default.
- W4286587583 cites W2605479606 @default.
- W4286587583 cites W2606051721 @default.
- W4286587583 cites W2616825195 @default.
- W4286587583 cites W2618591706 @default.
- W4286587583 cites W2734426471 @default.
- W4286587583 cites W2753871615 @default.
- W4286587583 cites W2756403351 @default.
- W4286587583 cites W2762609158 @default.
- W4286587583 cites W2765314233 @default.
- W4286587583 cites W2766903152 @default.
- W4286587583 cites W2767699537 @default.
- W4286587583 cites W2782333299 @default.
- W4286587583 cites W2790589159 @default.
- W4286587583 cites W2797068438 @default.
- W4286587583 cites W2798038951 @default.
- W4286587583 cites W2803417520 @default.
- W4286587583 cites W2809307170 @default.
- W4286587583 cites W2889133269 @default.
- W4286587583 cites W2899391538 @default.
- W4286587583 cites W2901366516 @default.
- W4286587583 cites W2909668868 @default.
- W4286587583 cites W2913442468 @default.
- W4286587583 cites W2921846932 @default.
- W4286587583 cites W2925756170 @default.
- W4286587583 cites W2930205604 @default.
- W4286587583 cites W2942123458 @default.
- W4286587583 cites W2942715272 @default.
- W4286587583 cites W2956016709 @default.
- W4286587583 cites W2967450000 @default.
- W4286587583 cites W2972674410 @default.
- W4286587583 cites W2973106630 @default.
- W4286587583 cites W2976586374 @default.
- W4286587583 cites W2987253676 @default.
- W4286587583 cites W2990153084 @default.
- W4286587583 cites W2992042179 @default.
- W4286587583 cites W2995998815 @default.
- W4286587583 cites W2996194551 @default.
- W4286587583 cites W2996819857 @default.
- W4286587583 cites W2997530335 @default.
- W4286587583 cites W3006318834 @default.
- W4286587583 cites W3006520677 @default.
- W4286587583 cites W3008359597 @default.
- W4286587583 cites W3015782419 @default.