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- W4286587590 abstract "Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with early-onset breast cancer. We found significant differential expression of the gene encoding potassium channel tetramerization domain-containing 15, KCTD15, when comparing primary tumors of the breast to the tissue of origin, the normal breast: in women aged 45 and younger, and women aged 70 and higher. KCTD15 was also differentially expressed in the brain metastases of patients with brain metastatic breast cancer. KCTD15 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of KCTD15 in primary tumors of the breast was correlated with overall survival in patients with basal, luminal B and HER2+ subtype breast cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. KCTD15 may be of relevance to initiation, maintenance or progression of cancers of the female breast." @default.
- W4286587590 created "2022-07-22" @default.
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- W4286587590 date "2022-07-22" @default.
- W4286587590 modified "2023-10-16" @default.
- W4286587590 title "Differential expression of KCTD15 in cancers of the breast." @default.
- W4286587590 doi "https://doi.org/10.31219/osf.io/cqf73" @default.
- W4286587590 hasPublicationYear "2022" @default.
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