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- W4286587598 abstract "Fibrotic tissues share many common features with neoplasms where there is an increased stiffness of the extracellular matrix (ECM). In this review, we present recent discoveries related to the role of the mechanosensitive ion channel Piezo1 in several diseases, especially in regulating tumor progression, and how this can be compared with cardiac mechanobiology. Based on recent findings, Piezo1 could be upregulated in cardiac fibroblasts as a consequence of the mechanical stress and pro-inflammatory stimuli that occurs after myocardial injury, and its increased activity could be responsible for a positive feedback loop that leads to fibrosis progression. The increased Piezo1-mediated calcium flow may play an important role in cytoskeleton reorganization since it induces actin stress fibers formation, a well-known characteristic of fibroblast transdifferentiation into the activated myofibroblast. Moreover, Piezo1 activity stimulates ECM and cytokines production, which in turn promotes the phenoconversion of adjacent fibroblasts into new myofibroblasts, enhancing the invasive character. Thus, by assuming the Piezo1 involvement in the activation of intrinsic fibroblasts, recruitment of new myofibroblasts, and uncontrolled excessive ECM production, a new approach to blocking the fibrotic progression can be predicted. Therefore, targeted therapies against Piezo1 could also be beneficial for cardiac fibrosis." @default.
- W4286587598 created "2022-07-22" @default.
- W4286587598 creator A5003951356 @default.
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- W4286587598 creator A5056427677 @default.
- W4286587598 creator A5074125267 @default.
- W4286587598 date "2022-07-22" @default.
- W4286587598 modified "2023-10-17" @default.
- W4286587598 title "Piezo1 Channel as a Potential Target for Hindering Cardiac Fibrotic Remodeling" @default.
- W4286587598 cites W1496643658 @default.
- W4286587598 cites W1626382598 @default.
- W4286587598 cites W1928745964 @default.
- W4286587598 cites W1955400364 @default.
- W4286587598 cites W1964851005 @default.
- W4286587598 cites W1966485417 @default.
- W4286587598 cites W1969049128 @default.
- W4286587598 cites W1972071814 @default.
- W4286587598 cites W1974797581 @default.
- W4286587598 cites W1975367328 @default.
- W4286587598 cites W1979069664 @default.
- W4286587598 cites W1983281361 @default.
- W4286587598 cites W1990374465 @default.
- W4286587598 cites W1991455457 @default.
- W4286587598 cites W1995592152 @default.
- W4286587598 cites W1997711954 @default.
- W4286587598 cites W1999720993 @default.
- W4286587598 cites W2000465700 @default.
- W4286587598 cites W2004659005 @default.
- W4286587598 cites W2005868264 @default.
- W4286587598 cites W2007586155 @default.
- W4286587598 cites W2014812641 @default.
- W4286587598 cites W2016193552 @default.
- W4286587598 cites W2019427642 @default.
- W4286587598 cites W2028446666 @default.
- W4286587598 cites W2030094330 @default.
- W4286587598 cites W2036145275 @default.
- W4286587598 cites W2041427079 @default.
- W4286587598 cites W2049782913 @default.
- W4286587598 cites W2051788770 @default.
- W4286587598 cites W2051816002 @default.
- W4286587598 cites W2058738554 @default.
- W4286587598 cites W2063277345 @default.
- W4286587598 cites W2077633415 @default.
- W4286587598 cites W2081848364 @default.
- W4286587598 cites W2082837373 @default.
- W4286587598 cites W2086822491 @default.
- W4286587598 cites W2087495354 @default.
- W4286587598 cites W2089089629 @default.
- W4286587598 cites W2093726551 @default.
- W4286587598 cites W2098030130 @default.
- W4286587598 cites W2098774098 @default.
- W4286587598 cites W2104190934 @default.
- W4286587598 cites W2105231460 @default.
- W4286587598 cites W2110889721 @default.
- W4286587598 cites W2125649895 @default.
- W4286587598 cites W2134265214 @default.
- W4286587598 cites W2151168522 @default.
- W4286587598 cites W2155347215 @default.
- W4286587598 cites W2160579895 @default.
- W4286587598 cites W2160644893 @default.
- W4286587598 cites W2161918376 @default.
- W4286587598 cites W2163388642 @default.
- W4286587598 cites W2164950412 @default.
- W4286587598 cites W2165254772 @default.
- W4286587598 cites W2168072233 @default.
- W4286587598 cites W2170350209 @default.
- W4286587598 cites W2301678655 @default.
- W4286587598 cites W2316911260 @default.
- W4286587598 cites W2322527785 @default.
- W4286587598 cites W2335745392 @default.
- W4286587598 cites W2346671729 @default.
- W4286587598 cites W2407918174 @default.
- W4286587598 cites W2429902053 @default.
- W4286587598 cites W2462759503 @default.
- W4286587598 cites W2530131374 @default.
- W4286587598 cites W2555705980 @default.
- W4286587598 cites W2589971096 @default.
- W4286587598 cites W2597639984 @default.
- W4286587598 cites W2604497571 @default.
- W4286587598 cites W2604895296 @default.
- W4286587598 cites W2606062902 @default.
- W4286587598 cites W2608817389 @default.
- W4286587598 cites W2610549085 @default.
- W4286587598 cites W2614814213 @default.
- W4286587598 cites W2615881490 @default.
- W4286587598 cites W2616087011 @default.
- W4286587598 cites W2684441367 @default.
- W4286587598 cites W2730872653 @default.
- W4286587598 cites W2735977809 @default.
- W4286587598 cites W2752163435 @default.
- W4286587598 cites W2767701190 @default.
- W4286587598 cites W2779962245 @default.
- W4286587598 cites W2793563162 @default.
- W4286587598 cites W2794340792 @default.
- W4286587598 cites W2794849131 @default.
- W4286587598 cites W2794944257 @default.
- W4286587598 cites W2795448946 @default.