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• W4286598082 abstract "Cellular senescence is a debatably irreversible block on the proliferation of potentially oncogenic or damaged cells. Senescent cells comprise heterogeneous and evolving states with various phenotypes based on cell type, senescence etiology, and degree of senescence. The accumulation of senescent cells with age and disease progression reflects a combination of dysfunctional senescent cell clearance and upregulated senescence induction by stress, telomere erosion, paracrine signaling, and DNA damage. A hallmark of senescent cells is the secretion of proinflammatory proteins, and growth and necrotic factors, in an expression phenotype termed the senescence-associated secretory phenotype (SASP). SASPs modulate the immune response to senescent cells and can induce senescence in other cells. This creates a positive feedback loop of induction and inflammation, which may explain its association with chronic inflammatory disorders such as Alzheimer’s, diabetes, and chronic kidney disease. In this chapter, we discuss the potency of senescent cell-targeting therapeutics, or “Senotherapeutics,” as strategies against age-related disorders. Clearing senescent cells improves cell viability in vitro and tissue function, halts the progression of age-related disorders, and increases lifespan in vivo. We explore “Senolytics,” molecules that induce cell death in senescent cells, immunomodulators that condition the immune response, vaccines that may boost immune cell-mediated clearance of senescent cells, senescence-reversing agents, and SASP-inhibitory agents that aid net clearance by preventing further senescence induction. As senotherapeutics begin to populate clinical trials, we outline the challenges in drug repurposing and efficacy, and target identification that will decide their future in treating age-related disorders." @default.
• W4286598082 created "2022-07-22" @default.
• W4286598082 creator A5042988569 @default.
• W4286598082 creator A5075109650 @default.
• W4286598082 date "2022-01-01" @default.
• W4286598082 modified "2023-10-16" @default.
• W4286598082 title "Clearance of senescent cells: potent anti-aging approach" @default.
• W4286598082 cites W1033197108 @default.
• W4286598082 cites W1702885827 @default.
• W4286598082 cites W1910950086 @default.
• W4286598082 cites W1932046626 @default.
• W4286598082 cites W1970924670 @default.
• W4286598082 cites W1973300568 @default.
• W4286598082 cites W1975258835 @default.
• W4286598082 cites W2001699624 @default.
• W4286598082 cites W2023845721 @default.
• W4286598082 cites W2042140414 @default.
• W4286598082 cites W2067833766 @default.
• W4286598082 cites W2080590768 @default.
• W4286598082 cites W2094197540 @default.
• W4286598082 cites W2104397341 @default.
• W4286598082 cites W2105218405 @default.
• W4286598082 cites W2115852450 @default.
• W4286598082 cites W2130458932 @default.
• W4286598082 cites W2167550136 @default.
• W4286598082 cites W2193792657 @default.
• W4286598082 cites W2210634983 @default.
• W4286598082 cites W2266290735 @default.
• W4286598082 cites W2403350024 @default.
• W4286598082 cites W2470410803 @default.
• W4286598082 cites W2499070802 @default.
• W4286598082 cites W2593208709 @default.
• W4286598082 cites W2594683399 @default.
• W4286598082 cites W2612435930 @default.
• W4286598082 cites W2616605368 @default.
• W4286598082 cites W2753524716 @default.
• W4286598082 cites W2766438319 @default.
• W4286598082 cites W2790749994 @default.
• W4286598082 cites W2793474173 @default.
• W4286598082 cites W2802384001 @default.
• W4286598082 cites W2804285711 @default.
• W4286598082 cites W2804341160 @default.
• W4286598082 cites W2809248765 @default.
• W4286598082 cites W2810250321 @default.
• W4286598082 cites W2890873793 @default.
• W4286598082 cites W2893617001 @default.
• W4286598082 cites W2899243313 @default.
• W4286598082 cites W2901275685 @default.
• W4286598082 cites W2901293244 @default.
• W4286598082 cites W2903331848 @default.
• W4286598082 cites W2904408826 @default.
• W4286598082 cites W2906721882 @default.
• W4286598082 cites W2913600879 @default.
• W4286598082 cites W2915779410 @default.
• W4286598082 cites W2921478729 @default.
• W4286598082 cites W2929830445 @default.
• W4286598082 cites W2931875016 @default.
• W4286598082 cites W2935344533 @default.
• W4286598082 cites W2951114010 @default.
• W4286598082 cites W2954240092 @default.
• W4286598082 cites W2961396211 @default.
• W4286598082 cites W2962580752 @default.
• W4286598082 cites W2974643180 @default.
• W4286598082 cites W2976108770 @default.
• W4286598082 cites W2980879216 @default.
• W4286598082 cites W2981220896 @default.
• W4286598082 cites W2993917443 @default.
• W4286598082 cites W3001142947 @default.
• W4286598082 cites W3006297561 @default.
• W4286598082 cites W3009846583 @default.
• W4286598082 cites W3010830192 @default.
• W4286598082 cites W3011369649 @default.
• W4286598082 cites W3014006805 @default.
• W4286598082 cites W3018442280 @default.
• W4286598082 cites W3021816293 @default.
• W4286598082 cites W3021903614 @default.
• W4286598082 cites W3022847059 @default.
• W4286598082 cites W3025956887 @default.
• W4286598082 cites W3032449805 @default.
• W4286598082 cites W3032765970 @default.
• W4286598082 cites W3033613861 @default.
• W4286598082 cites W3036603151 @default.
• W4286598082 cites W3037268978 @default.
• W4286598082 cites W3038217579 @default.
• W4286598082 cites W3038795705 @default.
• W4286598082 cites W3041106862 @default.
• W4286598082 cites W3087504560 @default.
• W4286598082 cites W3087598675 @default.
• W4286598082 cites W3092172736 @default.
• W4286598082 cites W3093701510 @default.
• W4286598082 cites W3108996799 @default.
• W4286598082 cites W3109445174 @default.
• W4286598082 cites W3117211004 @default.
• W4286598082 cites W4210433744 @default.
• W4286598082 cites W620553544 @default.
• W4286598082 doi "https://doi.org/10.1016/b978-0-323-90235-9.00002-1" @default.
• W4286598082 hasPublicationYear "2022" @default.
• W4286598082 type Work @default.

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