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• W4286598839 endingPage "52" @default.
• W4286598839 startingPage "33" @default.
• W4286598839 abstract "MicroRNAs (miRNAs) are key posttranscriptional regulators of gene expression in many cellular pathways, and play critical functions in developmental and pathological processes. Thus, alterations in the levels of individual or entire families of miRNAs are associated with the pathogenesis of a wide range of human and animal diseases. Indeed, disease-associated miRNAs represent a new class of targets for the development of miRNA-based therapeutic modalities. The interest in miRNA research has accelerated the development of several in vitro and in vivo experimental approaches for probing miRNA functions by means of miRNA interference (RNAi). This chapter will summarize and assess the technologies that have demonstrated their efficacy and reliability in inhibiting and enhancing miRNA expression. Furthermore, we describe the most commonly used in vivo delivery strategies for miRNAi. Finally, we critically summarize recent progress of therapeutics based on miRNAi and their impact in human diseases." @default.
• W4286598839 created "2022-07-22" @default.
• W4286598839 creator A5045201369 @default.
• W4286598839 creator A5052350151 @default.
• W4286598839 creator A5069082315 @default.
• W4286598839 date "2022-01-01" @default.
• W4286598839 modified "2023-10-16" @default.
• W4286598839 title "MicroRNA interference" @default.
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