Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286632139> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4286632139 abstract "Abstract Background: Lymphopenia was often observed during follow-up for cancer patients, this study aimed to evaluate the prognostic value of prolonged lymphopenia for breast cancer patients. Methods: This was a retrospective cohort analysis of 296 patients with clinical stage I-III operable breast cancer, who had received chemotherapy and/or radiotherapy. Absolute lymphocyte count lower than 1.1×10^3/ul was defined as lymphopenia. Lymphopenia around the 6 th month after chemo-radiotherapy was defined as cohort L, while normal Absolute lymphocyte count was defined as cohort N. Predictors of lymphopenia were assessed using univariate and multivariate logistic regression analyses. Kaplan–Meier and Cox regression analyses were used to evaluate the relationship between the two cohorts. Results: The baseline characteristics analysis: comparing to cohort N, cohort L had more Stage III(47.4% vs. 25.5%) and less Stage I cancer(12.3% vs. 20.1%)(p=0.005), more patients experienced combined chemotherapy regimen(86.0% vs. 69.5%, p=0.012), more patients experienced radiotherapy(78.9% vs. 64.9%, p=0.041), and less patients experienced endocrine therapy(54.4% vs. 68.2%, p=0.049). Multivariate logistic regression analysis revealed two negative independent factors associated with DFS: pTNM staging (stage II vs. I: HR=5.346, 95% CI: 2.286-12.504, p<0.001; stage III vs. II: HR=3.089, 95% CI:1.739-5.487, p<0.001), and ALC status 6 months after chemo- and/or radiotherapy (HR=2.445, 95% CI: 1.577-3.788, p<0.001). Cohort L had significantly shorter DFS (log rank: p< 0.001), as well as significantly shorter OS (log rank: p< 0.001). Conclusion: Persistent lymphopenia after chemotherapy and/or radiotherapy was an independent predictor for breast cancer relapse and unfavorable survival." @default.
- W4286632139 created "2022-07-23" @default.
- W4286632139 creator A5000122749 @default.
- W4286632139 creator A5018302078 @default.
- W4286632139 creator A5018792250 @default.
- W4286632139 creator A5030147905 @default.
- W4286632139 creator A5037188176 @default.
- W4286632139 creator A5040843106 @default.
- W4286632139 creator A5047108686 @default.
- W4286632139 creator A5051653656 @default.
- W4286632139 creator A5059010780 @default.
- W4286632139 creator A5062862687 @default.
- W4286632139 creator A5082571425 @default.
- W4286632139 creator A5087879286 @default.
- W4286632139 date "2022-07-06" @default.
- W4286632139 modified "2023-10-18" @default.
- W4286632139 title "Persistent lymphopenia after chemotherapy and/or radiotherapy predicted unfavorable outcome in breast cancer patients - a retrospective cohort study" @default.
- W4286632139 doi "https://doi.org/10.21203/rs.3.rs-1603322/v2" @default.
- W4286632139 hasPublicationYear "2022" @default.
- W4286632139 type Work @default.
- W4286632139 citedByCount "0" @default.
- W4286632139 crossrefType "posted-content" @default.
- W4286632139 hasAuthorship W4286632139A5000122749 @default.
- W4286632139 hasAuthorship W4286632139A5018302078 @default.
- W4286632139 hasAuthorship W4286632139A5018792250 @default.
- W4286632139 hasAuthorship W4286632139A5030147905 @default.
- W4286632139 hasAuthorship W4286632139A5037188176 @default.
- W4286632139 hasAuthorship W4286632139A5040843106 @default.
- W4286632139 hasAuthorship W4286632139A5047108686 @default.
- W4286632139 hasAuthorship W4286632139A5051653656 @default.
- W4286632139 hasAuthorship W4286632139A5059010780 @default.
- W4286632139 hasAuthorship W4286632139A5062862687 @default.
- W4286632139 hasAuthorship W4286632139A5082571425 @default.
- W4286632139 hasAuthorship W4286632139A5087879286 @default.
- W4286632139 hasBestOaLocation W42866321391 @default.
- W4286632139 hasConcept C121608353 @default.
- W4286632139 hasConcept C126322002 @default.
- W4286632139 hasConcept C143998085 @default.
- W4286632139 hasConcept C144301174 @default.
- W4286632139 hasConcept C146357865 @default.
- W4286632139 hasConcept C151730666 @default.
- W4286632139 hasConcept C151956035 @default.
- W4286632139 hasConcept C167135981 @default.
- W4286632139 hasConcept C2776694085 @default.
- W4286632139 hasConcept C2781413609 @default.
- W4286632139 hasConcept C38180746 @default.
- W4286632139 hasConcept C50382708 @default.
- W4286632139 hasConcept C509974204 @default.
- W4286632139 hasConcept C530470458 @default.
- W4286632139 hasConcept C71924100 @default.
- W4286632139 hasConcept C72563966 @default.
- W4286632139 hasConcept C86803240 @default.
- W4286632139 hasConcept C90924648 @default.
- W4286632139 hasConceptScore W4286632139C121608353 @default.
- W4286632139 hasConceptScore W4286632139C126322002 @default.
- W4286632139 hasConceptScore W4286632139C143998085 @default.
- W4286632139 hasConceptScore W4286632139C144301174 @default.
- W4286632139 hasConceptScore W4286632139C146357865 @default.
- W4286632139 hasConceptScore W4286632139C151730666 @default.
- W4286632139 hasConceptScore W4286632139C151956035 @default.
- W4286632139 hasConceptScore W4286632139C167135981 @default.
- W4286632139 hasConceptScore W4286632139C2776694085 @default.
- W4286632139 hasConceptScore W4286632139C2781413609 @default.
- W4286632139 hasConceptScore W4286632139C38180746 @default.
- W4286632139 hasConceptScore W4286632139C50382708 @default.
- W4286632139 hasConceptScore W4286632139C509974204 @default.
- W4286632139 hasConceptScore W4286632139C530470458 @default.
- W4286632139 hasConceptScore W4286632139C71924100 @default.
- W4286632139 hasConceptScore W4286632139C72563966 @default.
- W4286632139 hasConceptScore W4286632139C86803240 @default.
- W4286632139 hasConceptScore W4286632139C90924648 @default.
- W4286632139 hasLocation W42866321391 @default.
- W4286632139 hasOpenAccess W4286632139 @default.
- W4286632139 hasPrimaryLocation W42866321391 @default.
- W4286632139 hasRelatedWork W1975479077 @default.
- W4286632139 hasRelatedWork W1988030834 @default.
- W4286632139 hasRelatedWork W2234839489 @default.
- W4286632139 hasRelatedWork W2361700749 @default.
- W4286632139 hasRelatedWork W2363865786 @default.
- W4286632139 hasRelatedWork W2388730008 @default.
- W4286632139 hasRelatedWork W2994794698 @default.
- W4286632139 hasRelatedWork W3035870079 @default.
- W4286632139 hasRelatedWork W4220939315 @default.
- W4286632139 hasRelatedWork W4291189777 @default.
- W4286632139 isParatext "false" @default.
- W4286632139 isRetracted "false" @default.
- W4286632139 workType "article" @default.