Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286632583> ?p ?o ?g. }
- W4286632583 abstract "Immunotherapy with T cells genetically modified with chimeric antigen receptors (CARs) has shown significant clinical efficacy in patients with relapsed/refractory B-cell lymphoma. Nevertheless, more than 50% of treated patients do not benefit from such therapy due to either absence of response or further relapse. Elucidation of clinical and biological features that would predict clinical response to CART19 therapy is of paramount importance and eventually may allow for selection of those patients with greater chances of response. In the last 5 years, significant clinical experience has been obtained in the treatment of diffuse large B-cell lymphoma (DLBCL) patients with CAR19 T cells, and major advances have been made on the understanding of CART19 efficacy mechanisms. In this review, we discuss clinical and tumor features associated with response to CART19 in DLBCL patients as well as the impact of biological features of the infusion CART19 product on the clinical response. Prognosis of DLBCL patients that fail CART19 is poor and therapeutic approaches with new drugs are also discussed." @default.
- W4286632583 created "2022-07-23" @default.
- W4286632583 creator A5023720691 @default.
- W4286632583 creator A5053280136 @default.
- W4286632583 creator A5071949122 @default.
- W4286632583 creator A5088317216 @default.
- W4286632583 date "2022-07-06" @default.
- W4286632583 modified "2023-10-06" @default.
- W4286632583 title "CAR T-Cell Therapy Predictive Response Markers in Diffuse Large B-Cell Lymphoma and Therapeutic Options After CART19 Failure" @default.
- W4286632583 cites W1481612531 @default.
- W4286632583 cites W1963522404 @default.
- W4286632583 cites W1966542058 @default.
- W4286632583 cites W1982795546 @default.
- W4286632583 cites W1989273697 @default.
- W4286632583 cites W1996815863 @default.
- W4286632583 cites W1998278019 @default.
- W4286632583 cites W2016853666 @default.
- W4286632583 cites W2018071905 @default.
- W4286632583 cites W2018311892 @default.
- W4286632583 cites W2020604513 @default.
- W4286632583 cites W2020789296 @default.
- W4286632583 cites W2028460943 @default.
- W4286632583 cites W2034881106 @default.
- W4286632583 cites W2047205338 @default.
- W4286632583 cites W2050297562 @default.
- W4286632583 cites W2052587346 @default.
- W4286632583 cites W2052749202 @default.
- W4286632583 cites W2059128083 @default.
- W4286632583 cites W2060466778 @default.
- W4286632583 cites W2069832110 @default.
- W4286632583 cites W2071548401 @default.
- W4286632583 cites W2075627595 @default.
- W4286632583 cites W2075864830 @default.
- W4286632583 cites W2077184259 @default.
- W4286632583 cites W2077941010 @default.
- W4286632583 cites W2096596684 @default.
- W4286632583 cites W2099570622 @default.
- W4286632583 cites W2099736081 @default.
- W4286632583 cites W2104173785 @default.
- W4286632583 cites W2105400883 @default.
- W4286632583 cites W2113802879 @default.
- W4286632583 cites W2124373740 @default.
- W4286632583 cites W2127734125 @default.
- W4286632583 cites W2130011407 @default.
- W4286632583 cites W2132923173 @default.
- W4286632583 cites W2137816642 @default.
- W4286632583 cites W2139047632 @default.
- W4286632583 cites W2141410122 @default.
- W4286632583 cites W2144796561 @default.
- W4286632583 cites W2150587745 @default.
- W4286632583 cites W2156506990 @default.
- W4286632583 cites W2158346246 @default.
- W4286632583 cites W2164337721 @default.
- W4286632583 cites W2166487857 @default.
- W4286632583 cites W2170513194 @default.
- W4286632583 cites W2179454156 @default.
- W4286632583 cites W2219506342 @default.
- W4286632583 cites W2236959863 @default.
- W4286632583 cites W2296829012 @default.
- W4286632583 cites W2322790172 @default.
- W4286632583 cites W2342423058 @default.
- W4286632583 cites W2343125831 @default.
- W4286632583 cites W2401536218 @default.
- W4286632583 cites W2417431203 @default.
- W4286632583 cites W2480367868 @default.
- W4286632583 cites W2508616096 @default.
- W4286632583 cites W2508961955 @default.
- W4286632583 cites W2509364267 @default.
- W4286632583 cites W2523343293 @default.
- W4286632583 cites W2528306813 @default.
- W4286632583 cites W2551804989 @default.
- W4286632583 cites W2566677727 @default.
- W4286632583 cites W2570323108 @default.
- W4286632583 cites W2571138221 @default.
- W4286632583 cites W2579884965 @default.
- W4286632583 cites W2598700764 @default.
- W4286632583 cites W2602369513 @default.
- W4286632583 cites W2606654718 @default.
- W4286632583 cites W2734515449 @default.
- W4286632583 cites W2744261860 @default.
- W4286632583 cites W2765314233 @default.
- W4286632583 cites W2766877982 @default.
- W4286632583 cites W2766903152 @default.
- W4286632583 cites W2773804840 @default.
- W4286632583 cites W2774935690 @default.
- W4286632583 cites W2775369717 @default.
- W4286632583 cites W2781864644 @default.
- W4286632583 cites W2787301955 @default.
- W4286632583 cites W2787621143 @default.
- W4286632583 cites W2792232222 @default.
- W4286632583 cites W2797413896 @default.
- W4286632583 cites W2797429263 @default.
- W4286632583 cites W2800949131 @default.
- W4286632583 cites W2801641802 @default.
- W4286632583 cites W2805923035 @default.
- W4286632583 cites W2807819616 @default.
- W4286632583 cites W2886274086 @default.
- W4286632583 cites W2888063816 @default.
- W4286632583 cites W2891902322 @default.
- W4286632583 cites W2893691711 @default.