Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286632992> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4286632992 abstract "Abstract Huntington's disease is a progressive, neurodegenerative, and inherited disease. Antioxidants have been shown effective in slowing disease progression in animal models of HD and are under investigation in human clinical trials. α-Pinene, a polyphenolic compound of the terpene family, has been shown to exert antioxidant activity. Therefore, this study aimed to investigate the impact of α-pinene on animal model of HD. Thirty-two male Wistar rats received 3-Nitropropionic acid (3-NP) for induction of the disease model or treated with α-pinene + 3-NP in different groups. Motor skill, and biochemical evaluations to detect oxidant/antioxidant markers in rat cortex and striatum were performed in all groups. We found that α-pinene significantly improved 3-NP-induced changes in the body weight, rotarod activity, time taken to cross the narrow beam, and locomotor activity. Biochemical analysis revealed that α-pinene significantly decreased the 3NP-induced elevation in oxidant markers, nitrite, and malondialdehyde in both cortex and striatum. In addition, α-pinene counteracted the 3NP-induced fall in antioxidant enzymes, including superoxide dismutase, catalase, and glutathione in the cortex and striatum. In conclusion, we found that α-pinene prevented the motor dysfunction induced by 3-NP in the animal model of Huntington’s disease. Oxidants-antioxidant balance might be involved in the protective effect of α-pinene." @default.
- W4286632992 created "2022-07-23" @default.
- W4286632992 creator A5031280573 @default.
- W4286632992 creator A5037882634 @default.
- W4286632992 creator A5058878376 @default.
- W4286632992 creator A5086860801 @default.
- W4286632992 creator A5091298501 @default.
- W4286632992 date "2022-07-06" @default.
- W4286632992 modified "2023-10-18" @default.
- W4286632992 title "Alpha-Pinene alleviates motor activity in animal model of Huntington’s disease via enhancing antioxidant capacity" @default.
- W4286632992 doi "https://doi.org/10.21203/rs.3.rs-1781984/v1" @default.
- W4286632992 hasPublicationYear "2022" @default.
- W4286632992 type Work @default.
- W4286632992 citedByCount "0" @default.
- W4286632992 crossrefType "posted-content" @default.
- W4286632992 hasAuthorship W4286632992A5031280573 @default.
- W4286632992 hasAuthorship W4286632992A5037882634 @default.
- W4286632992 hasAuthorship W4286632992A5058878376 @default.
- W4286632992 hasAuthorship W4286632992A5086860801 @default.
- W4286632992 hasAuthorship W4286632992A5091298501 @default.
- W4286632992 hasBestOaLocation W42866329921 @default.
- W4286632992 hasConcept C126322002 @default.
- W4286632992 hasConcept C178790620 @default.
- W4286632992 hasConcept C185592680 @default.
- W4286632992 hasConcept C2775838275 @default.
- W4286632992 hasConcept C2776151105 @default.
- W4286632992 hasConcept C2777981454 @default.
- W4286632992 hasConcept C2778004101 @default.
- W4286632992 hasConcept C2778401633 @default.
- W4286632992 hasConcept C2778979269 @default.
- W4286632992 hasConcept C2779134260 @default.
- W4286632992 hasConcept C2779906576 @default.
- W4286632992 hasConcept C2780062018 @default.
- W4286632992 hasConcept C2780647506 @default.
- W4286632992 hasConcept C2985495968 @default.
- W4286632992 hasConcept C513476851 @default.
- W4286632992 hasConcept C55493867 @default.
- W4286632992 hasConcept C71924100 @default.
- W4286632992 hasConcept C98274493 @default.
- W4286632992 hasConceptScore W4286632992C126322002 @default.
- W4286632992 hasConceptScore W4286632992C178790620 @default.
- W4286632992 hasConceptScore W4286632992C185592680 @default.
- W4286632992 hasConceptScore W4286632992C2775838275 @default.
- W4286632992 hasConceptScore W4286632992C2776151105 @default.
- W4286632992 hasConceptScore W4286632992C2777981454 @default.
- W4286632992 hasConceptScore W4286632992C2778004101 @default.
- W4286632992 hasConceptScore W4286632992C2778401633 @default.
- W4286632992 hasConceptScore W4286632992C2778979269 @default.
- W4286632992 hasConceptScore W4286632992C2779134260 @default.
- W4286632992 hasConceptScore W4286632992C2779906576 @default.
- W4286632992 hasConceptScore W4286632992C2780062018 @default.
- W4286632992 hasConceptScore W4286632992C2780647506 @default.
- W4286632992 hasConceptScore W4286632992C2985495968 @default.
- W4286632992 hasConceptScore W4286632992C513476851 @default.
- W4286632992 hasConceptScore W4286632992C55493867 @default.
- W4286632992 hasConceptScore W4286632992C71924100 @default.
- W4286632992 hasConceptScore W4286632992C98274493 @default.
- W4286632992 hasLocation W42866329921 @default.
- W4286632992 hasOpenAccess W4286632992 @default.
- W4286632992 hasPrimaryLocation W42866329921 @default.
- W4286632992 hasRelatedWork W125774832 @default.
- W4286632992 hasRelatedWork W188720285 @default.
- W4286632992 hasRelatedWork W2038060280 @default.
- W4286632992 hasRelatedWork W2066852536 @default.
- W4286632992 hasRelatedWork W2314286400 @default.
- W4286632992 hasRelatedWork W2602111502 @default.
- W4286632992 hasRelatedWork W2609793639 @default.
- W4286632992 hasRelatedWork W2900924817 @default.
- W4286632992 hasRelatedWork W2994331181 @default.
- W4286632992 hasRelatedWork W3195549263 @default.
- W4286632992 isParatext "false" @default.
- W4286632992 isRetracted "false" @default.
- W4286632992 workType "article" @default.