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- W4286655741 endingPage "117" @default.
- W4286655741 startingPage "99" @default.
- W4286655741 abstract "Pain sensation is a normal physiological response to alert and prevent further tissue damage. It involves the perception of external stimuli by somatosensory neurons, then transmission of the message to various other types of neurons present in the spinal cord and brain to generate an appropriate response. Currently available analgesics exhibit very modest efficacy, and that too in only a subset of patients with chronic pain conditions, particularly neuropathic pain. The G protein-coupled receptors (GPCRs) are expressed on presynaptic, postsynaptic terminals, and soma of somatosensory neurons, which binds to various types of ligands to modulate neuronal activity and thus pain sensation in both directions. Fundamentally, neuropathic pain arises due to aberrant neuronal plasticity, which includes the sensitization of peripheral primary afferents (dorsal root ganglia and trigeminal ganglia) and the sensitization of central nociceptive neurons in the spinal cord or trigeminal nucleus or brain stem and cortex. Owing to the expression profiles of GPCRs in somatosensory neurons and other neuroanatomical regions involved in pain processing and transmission, this article shall focus only on four families of GPCRs: 1- Opioid receptors, 2-Cannabinoid receptors, 3-Adenosine receptors, and 4-Chemokine receptors." @default.
- W4286655741 created "2022-07-23" @default.
- W4286655741 creator A5038542864 @default.
- W4286655741 creator A5049054862 @default.
- W4286655741 creator A5062903002 @default.
- W4286655741 creator A5090122866 @default.
- W4286655741 date "2022-01-01" @default.
- W4286655741 modified "2023-10-03" @default.
- W4286655741 title "Targeting G protein coupled receptors for alleviating neuropathic pain" @default.
- W4286655741 cites W100098653 @default.
- W4286655741 cites W1480176511 @default.
- W4286655741 cites W1550940982 @default.
- W4286655741 cites W1637996628 @default.
- W4286655741 cites W1661652663 @default.
- W4286655741 cites W1826960795 @default.
- W4286655741 cites W1891953138 @default.
- W4286655741 cites W1919448202 @default.
- W4286655741 cites W1964215798 @default.
- W4286655741 cites W1970796628 @default.
- W4286655741 cites W1972907659 @default.
- W4286655741 cites W1979569718 @default.
- W4286655741 cites W1979675387 @default.
- W4286655741 cites W1990708187 @default.
- W4286655741 cites W1991319303 @default.
- W4286655741 cites W1993102927 @default.
- W4286655741 cites W1993285878 @default.
- W4286655741 cites W1996746265 @default.
- W4286655741 cites W1996987808 @default.
- W4286655741 cites W2009812771 @default.
- W4286655741 cites W2020196989 @default.
- W4286655741 cites W2023860870 @default.
- W4286655741 cites W2024941342 @default.
- W4286655741 cites W2026097155 @default.
- W4286655741 cites W2026808357 @default.
- W4286655741 cites W2029614668 @default.
- W4286655741 cites W2032609258 @default.
- W4286655741 cites W2046296795 @default.
- W4286655741 cites W2049628760 @default.
- W4286655741 cites W2050338155 @default.
- W4286655741 cites W2050931359 @default.
- W4286655741 cites W2053458702 @default.
- W4286655741 cites W2057403693 @default.
- W4286655741 cites W2057633398 @default.
- W4286655741 cites W2062565407 @default.
- W4286655741 cites W2062830657 @default.
- W4286655741 cites W2068290096 @default.
- W4286655741 cites W2071801806 @default.
- W4286655741 cites W2074709986 @default.
- W4286655741 cites W2075715972 @default.
- W4286655741 cites W2078044085 @default.
- W4286655741 cites W2078865976 @default.
- W4286655741 cites W2081090537 @default.
- W4286655741 cites W2082707570 @default.
- W4286655741 cites W2084643091 @default.
- W4286655741 cites W2087838893 @default.
- W4286655741 cites W2092460680 @default.
- W4286655741 cites W2093924523 @default.
- W4286655741 cites W2094384373 @default.
- W4286655741 cites W2094469214 @default.
- W4286655741 cites W2094638520 @default.
- W4286655741 cites W2095045616 @default.
- W4286655741 cites W2104818454 @default.
- W4286655741 cites W2112924959 @default.
- W4286655741 cites W2115745004 @default.
- W4286655741 cites W2116147934 @default.
- W4286655741 cites W2121731026 @default.
- W4286655741 cites W2129143684 @default.
- W4286655741 cites W2130632774 @default.
- W4286655741 cites W2130753172 @default.
- W4286655741 cites W2134557769 @default.
- W4286655741 cites W2155524482 @default.
- W4286655741 cites W2168634451 @default.
- W4286655741 cites W2213314638 @default.
- W4286655741 cites W2268612623 @default.
- W4286655741 cites W2325416065 @default.
- W4286655741 cites W2331959327 @default.
- W4286655741 cites W2378230445 @default.
- W4286655741 cites W2512819857 @default.
- W4286655741 cites W2557809815 @default.
- W4286655741 cites W2612657724 @default.
- W4286655741 cites W2621496977 @default.
- W4286655741 cites W2725512209 @default.
- W4286655741 cites W2752069735 @default.
- W4286655741 cites W2770893462 @default.
- W4286655741 cites W2789922692 @default.
- W4286655741 cites W2794850243 @default.
- W4286655741 cites W2800457250 @default.
- W4286655741 cites W2805539079 @default.
- W4286655741 cites W2807281752 @default.
- W4286655741 cites W2890801064 @default.
- W4286655741 cites W2922184287 @default.
- W4286655741 cites W2940073658 @default.
- W4286655741 cites W3005211134 @default.
- W4286655741 cites W3005973888 @default.
- W4286655741 cites W3099599005 @default.
- W4286655741 cites W3104253340 @default.
- W4286655741 cites W3106049705 @default.
- W4286655741 cites W3126646721 @default.