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• W4286670794 abstract "Background Childhood obesity is associated with adult major depressive disorder (MDD), but their causality is not clear. Methods We performed a two-sample Mendelian randomization (MR) analysis to explore the causality of childhood body mass index (BMI) and childhood obesity on MDD, followed by a multivariable MR (MVMR) analysis to investigate the potential role of adult BMI in mediating such effect. We accessed genome-wide association summary statistics of childhood BMI, childhood obesity, adult BMI and adult MDD from the Early Growth Genetics consortium (nBMI = 47 541, nobesity = 24 160), the Genetic Investigation of Anthropometric Traits consortium (nadult_BMI = ∼700 000) and the Psychiatric Genomics consortium (nMDD = 500 199), respectively. The MR-PRESSO test was performed to remove SNPs with potential pleiotropic effect. The MR analysis was performed by inverse-variance weighted test. Further sensitivity analyses, including the MR-Egger intercept test and leave-one-out analysis, were performed to evaluate the reliability of the results. Results Our study found that childhood obesity might increase the odds of developing MDD in adults (OR = 1.03, 95% CI: 1.01–1.06, p = 2.6 × 10−3). Children with higher BMI were more likely to develop MDD in adulthood, with an OR of 1.12 per standard deviation score (SDS) increase in BMI (95% CI: 1.07–1.17, p = 4.4 × 10−7). Sensitivity analyses verified the reliability of the causality between childhood BMI/obesity and MDD. Further MVMR results revealed that the impact of childhood BMI on MDD risk was predominantly mediated by adult BMI. Conclusion Our findings provided evidence of a causal relationship between childhood BMI/obesity and adult MDD, thus providing new insights into the prevention of MDD." @default.
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• W4286670794 date "2022-07-22" @default.
• W4286670794 modified "2023-10-17" @default.
• W4286670794 title "Mendelian randomization analysis identified causal Association of Childhood Obesity with adult major depressive disorder" @default.
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• W4286670794 doi "https://doi.org/10.1111/ijpo.12960" @default.
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