FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286697367> ?p ?o ?g. }

• W4286697367 abstract "In vitro maturation (IVM) refers to the process of developing immature oocytes into the mature in vitro under the microenvironment analogous to follicle fluid. It is an important technique for patients with polycystic ovary syndrome and, especially, those young patients with the need of fertility preservation. However, as the mechanisms of oocyte maturation have not been fully understood yet, the cultivation efficiency of IVM is not satisfactory. It was confirmed in our previous study that oocyte maturation was impaired after N-acetyltransferase 10 (NAT10) knockdown (KD). In the present study, we further explored the transcriptome alteration of NAT10-depleted oocytes and found that O-GlcNAcase ( OGA ) was an important target gene for NAT10-mediated ac4C modification in oocyte maturation. NAT10 might regulate OGA stability and expression by suppressing its degradation. To find out whether the influence of NAT10-mediated ac4C on oocyte maturation was mediated by OGA , we further explored the role of OGA in IVM. After knocking down OGA of oocytes, oocyte maturation was inhibited. In addition, as oocytes matured, OGA expression increased and, conversely, O-linked N-acetylglucosamine (O-GlcNAc) level decreased. On the basis of NAT10 KD transcriptome and OGA KD transcriptome data, NAT10-mediated ac4C modification of OGA might play a role through G protein–coupled receptors, molecular transduction, nucleosome DNA binding, and other mechanisms in oocyte maturation. Rsph6a , Gm7788 , Gm41780 , Trpc7 , Gm29036 , and Gm47144 were potential downstream genes. In conclusion, NAT10 maintained the stability of OGA transcript by ac4C modification on it, thus positively regulating IVM. Moreover, our study revealed the regulation mechanisms of oocytes maturation and provided reference for improving IVM outcomes. At the same time, the interaction between mRNA ac4C modification and protein O-GlcNAc modification was found for the first time, which enriched the regulation network of oocyte maturation." @default.
• W4286697367 created "2022-07-23" @default.
• W4286697367 creator A5008333363 @default.
• W4286697367 creator A5008911055 @default.
• W4286697367 creator A5013962913 @default.
• W4286697367 creator A5020700704 @default.
• W4286697367 creator A5023487841 @default.
• W4286697367 creator A5029838949 @default.
• W4286697367 creator A5037111397 @default.
• W4286697367 creator A5042696842 @default.
• W4286697367 creator A5053171345 @default.
• W4286697367 creator A5056475996 @default.
• W4286697367 creator A5056581525 @default.
• W4286697367 date "2022-07-22" @default.
• W4286697367 modified "2023-10-16" @default.
• W4286697367 title "NAT10 Maintains OGA mRNA Stability Through ac4C Modification in Regulating Oocyte Maturation" @default.
• W4286697367 cites W1568866400 @default.
• W4286697367 cites W1924099744 @default.
• W4286697367 cites W2042868184 @default.
• W4286697367 cites W2080380725 @default.
• W4286697367 cites W2096077902 @default.
• W4286697367 cites W2102278945 @default.
• W4286697367 cites W2109470455 @default.
• W4286697367 cites W2114499607 @default.
• W4286697367 cites W2138489179 @default.
• W4286697367 cites W2165434543 @default.
• W4286697367 cites W2179438025 @default.
• W4286697367 cites W2315881813 @default.
• W4286697367 cites W2331611239 @default.
• W4286697367 cites W2627064270 @default.
• W4286697367 cites W2769995426 @default.
• W4286697367 cites W2901932654 @default.
• W4286697367 cites W2904095049 @default.
• W4286697367 cites W2909473282 @default.
• W4286697367 cites W2917068997 @default.
• W4286697367 cites W2950464315 @default.
• W4286697367 cites W2965635599 @default.
• W4286697367 cites W2980604225 @default.
• W4286697367 cites W2980833500 @default.
• W4286697367 cites W2990291594 @default.
• W4286697367 cites W3004491707 @default.
• W4286697367 cites W3007049433 @default.
• W4286697367 cites W3009881134 @default.
• W4286697367 cites W3021036873 @default.
• W4286697367 cites W3034750978 @default.
• W4286697367 cites W3046654839 @default.
• W4286697367 cites W3081618492 @default.
• W4286697367 cites W3088405549 @default.
• W4286697367 cites W3105784566 @default.
• W4286697367 cites W3119677574 @default.
• W4286697367 cites W3122156717 @default.
• W4286697367 cites W3134145701 @default.
• W4286697367 cites W3139168703 @default.
• W4286697367 cites W3158703856 @default.
• W4286697367 cites W3158832418 @default.
• W4286697367 cites W3169236703 @default.
• W4286697367 cites W3190034507 @default.
• W4286697367 cites W4200395562 @default.
• W4286697367 cites W4210588589 @default.
• W4286697367 cites W4211056897 @default.
• W4286697367 cites W4214855994 @default.
• W4286697367 cites W1548261575 @default.
• W4286697367 doi "https://doi.org/10.3389/fendo.2022.907286" @default.
• W4286697367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35937804" @default.
• W4286697367 hasPublicationYear "2022" @default.
• W4286697367 type Work @default.
• W4286697367 citedByCount "6" @default.
• W4286697367 countsByYear W42866973672023 @default.
• W4286697367 crossrefType "journal-article" @default.
• W4286697367 hasAuthorship W4286697367A5008333363 @default.
• W4286697367 hasAuthorship W4286697367A5008911055 @default.
• W4286697367 hasAuthorship W4286697367A5013962913 @default.
• W4286697367 hasAuthorship W4286697367A5020700704 @default.
• W4286697367 hasAuthorship W4286697367A5023487841 @default.
• W4286697367 hasAuthorship W4286697367A5029838949 @default.
• W4286697367 hasAuthorship W4286697367A5037111397 @default.
• W4286697367 hasAuthorship W4286697367A5042696842 @default.
• W4286697367 hasAuthorship W4286697367A5053171345 @default.
• W4286697367 hasAuthorship W4286697367A5056475996 @default.
• W4286697367 hasAuthorship W4286697367A5056581525 @default.
• W4286697367 hasBestOaLocation W42866973671 @default.
• W4286697367 hasConcept C104317684 @default.
• W4286697367 hasConcept C126322002 @default.
• W4286697367 hasConcept C134018914 @default.
• W4286697367 hasConcept C150194340 @default.
• W4286697367 hasConcept C162317418 @default.
• W4286697367 hasConcept C16685009 @default.
• W4286697367 hasConcept C173396325 @default.
• W4286697367 hasConcept C196843134 @default.
• W4286697367 hasConcept C2775966511 @default.
• W4286697367 hasConcept C2776690073 @default.
• W4286697367 hasConcept C2777391703 @default.
• W4286697367 hasConcept C2779306644 @default.
• W4286697367 hasConcept C3018442814 @default.
• W4286697367 hasConcept C55493867 @default.
• W4286697367 hasConcept C71924100 @default.
• W4286697367 hasConcept C86803240 @default.
• W4286697367 hasConcept C95444343 @default.
• W4286697367 hasConceptScore W4286697367C104317684 @default.
• W4286697367 hasConceptScore W4286697367C126322002 @default.

• next