FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4286702004> ?p ?o ?g. }

• W4286702004 endingPage "597" @default.
• W4286702004 startingPage "587" @default.
• W4286702004 abstract "The authors evaluated the feasibility of using the first clinical-grade confocal laser endomicroscopy (CLE) system using fluorescein sodium for intraoperative in vivo imaging of brain tumors.A CLE system cleared by the FDA was used in 30 prospectively enrolled patients with 31 brain tumors (13 gliomas, 5 meningiomas, 6 other primary tumors, 3 metastases, and 4 reactive brain tissue). A neuropathologist classified CLE images as interpretable or noninterpretable. Images were compared with corresponding frozen and permanent histology sections, with image correlation to biopsy location using neuronavigation. The specificities and sensitivities of CLE images and frozen sections were calculated using permanent histological sections as the standard for comparison. A recently developed surgical telepathology software platform was used in 11 cases to provide real-time intraoperative consultation with a neuropathologist.Overall, 10,713 CLE images from 335 regions of interest were acquired. The mean duration of the use of the CLE system was 7 minutes (range 3-18 minutes). Interpretable CLE images were obtained in all cases. The first interpretable image was acquired within a mean of 6 (SD 10) images and within the first 5 (SD 13) seconds of imaging; 4896 images (46%) were interpretable. Interpretable image acquisition was positively correlated with study progression, number of cases per surgeon, cumulative length of CLE time, and CLE time per case (p ≤ 0.01). The diagnostic accuracy, sensitivity, and specificity of CLE compared with frozen sections were 94%, 94%, and 100%, respectively, and the diagnostic accuracy, sensitivity, and specificity of CLE compared with permanent histological sections were 92%, 90%, and 94%, respectively. No difference was observed between lesion types for the time to first interpretable image (p = 0.35). Deeply located lesions were associated with a higher percentage of interpretable images than superficial lesions (p = 0.02). The study met the primary end points, confirming the safety and feasibility and acquisition of noninvasive digital biopsies in all cases. The study met the secondary end points for the duration of CLE use necessary to obtain interpretable images. A neuropathologist could interpret the CLE images in 29 (97%) of 30 cases.The clinical-grade CLE system allows in vivo, intraoperative, high-resolution cellular visualization of tissue microstructure and identification of lesional tissue patterns in real time, without the need for tissue preparation." @default.
• W4286702004 created "2022-07-23" @default.
• W4286702004 creator A5025035801 @default.
• W4286702004 creator A5027044830 @default.
• W4286702004 creator A5033435512 @default.
• W4286702004 creator A5037512143 @default.
• W4286702004 creator A5040484699 @default.
• W4286702004 creator A5040939351 @default.
• W4286702004 creator A5041161334 @default.
• W4286702004 creator A5047715823 @default.
• W4286702004 creator A5050335101 @default.
• W4286702004 creator A5055257752 @default.
• W4286702004 creator A5059246529 @default.
• W4286702004 creator A5075772642 @default.
• W4286702004 creator A5078234471 @default.
• W4286702004 creator A5083325281 @default.
• W4286702004 date "2023-03-01" @default.
• W4286702004 modified "2023-10-14" @default.
• W4286702004 title "Intraoperative confocal laser endomicroscopy: prospective in vivo feasibility study of a clinical-grade system for brain tumors" @default.
• W4286702004 cites W2326952007 @default.
• W4286702004 doi "https://doi.org/10.3171/2022.5.jns2282" @default.
• W4286702004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35901698" @default.
• W4286702004 hasPublicationYear "2023" @default.
• W4286702004 type Work @default.
• W4286702004 citedByCount "10" @default.
• W4286702004 countsByYear W42867020042022 @default.
• W4286702004 countsByYear W42867020042023 @default.
• W4286702004 crossrefType "journal-article" @default.
• W4286702004 hasAuthorship W4286702004A5025035801 @default.
• W4286702004 hasAuthorship W4286702004A5027044830 @default.
• W4286702004 hasAuthorship W4286702004A5033435512 @default.
• W4286702004 hasAuthorship W4286702004A5037512143 @default.
• W4286702004 hasAuthorship W4286702004A5040484699 @default.
• W4286702004 hasAuthorship W4286702004A5040939351 @default.
• W4286702004 hasAuthorship W4286702004A5041161334 @default.
• W4286702004 hasAuthorship W4286702004A5047715823 @default.
• W4286702004 hasAuthorship W4286702004A5050335101 @default.
• W4286702004 hasAuthorship W4286702004A5055257752 @default.
• W4286702004 hasAuthorship W4286702004A5059246529 @default.
• W4286702004 hasAuthorship W4286702004A5075772642 @default.
• W4286702004 hasAuthorship W4286702004A5078234471 @default.
• W4286702004 hasAuthorship W4286702004A5083325281 @default.
• W4286702004 hasBestOaLocation W42867020041 @default.
• W4286702004 hasConcept C126838900 @default.
• W4286702004 hasConcept C142724271 @default.
• W4286702004 hasConcept C143409427 @default.
• W4286702004 hasConcept C2775934546 @default.
• W4286702004 hasConcept C2778195096 @default.
• W4286702004 hasConcept C2989005 @default.
• W4286702004 hasConcept C40993552 @default.
• W4286702004 hasConcept C544855455 @default.
• W4286702004 hasConcept C57742111 @default.
• W4286702004 hasConcept C71924100 @default.
• W4286702004 hasConceptScore W4286702004C126838900 @default.
• W4286702004 hasConceptScore W4286702004C142724271 @default.
• W4286702004 hasConceptScore W4286702004C143409427 @default.
• W4286702004 hasConceptScore W4286702004C2775934546 @default.
• W4286702004 hasConceptScore W4286702004C2778195096 @default.
• W4286702004 hasConceptScore W4286702004C2989005 @default.
• W4286702004 hasConceptScore W4286702004C40993552 @default.
• W4286702004 hasConceptScore W4286702004C544855455 @default.
• W4286702004 hasConceptScore W4286702004C57742111 @default.
• W4286702004 hasConceptScore W4286702004C71924100 @default.
• W4286702004 hasIssue "3" @default.
• W4286702004 hasLocation W42867020041 @default.
• W4286702004 hasLocation W42867020042 @default.
• W4286702004 hasOpenAccess W4286702004 @default.
• W4286702004 hasPrimaryLocation W42867020041 @default.
• W4286702004 hasRelatedWork W2946068364 @default.
• W4286702004 hasRelatedWork W3092023166 @default.
• W4286702004 hasRelatedWork W3111903003 @default.
• W4286702004 hasRelatedWork W3187376498 @default.
• W4286702004 hasRelatedWork W3215143150 @default.
• W4286702004 hasRelatedWork W4245471151 @default.
• W4286702004 hasRelatedWork W4292111241 @default.
• W4286702004 hasRelatedWork W4295127549 @default.
• W4286702004 hasRelatedWork W4312867903 @default.
• W4286702004 hasRelatedWork W4387065422 @default.
• W4286702004 hasVolume "138" @default.
• W4286702004 isParatext "false" @default.
• W4286702004 isRetracted "false" @default.
• W4286702004 workType "article" @default.