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- W4286715900 abstract "to the editor—We read with great interest the correspondence “Safety and Tolerability of Paxlovid (Nirmatrelvir/Ritonavir) in High-Risk Patients” by Pesko and colleagues from the University of Washington [1], and greatly appreciate their interest in our study [2]. Pesko and colleagues assessed tolerability and safety of Paxlovid in high-risk patients, through telephonic postprescription outreach, and found high incidence of adverse effects. Alongside the rise in the use of Paxlovid comes the need to evaluate the adverse effects of this in a real-world setting [3]. However, our study aimed to evaluate the effectiveness of Paxlovid in a real-world setting in means of preventing severe COVID-19 and mortality [2]. Unfortunately, we have no data of Paxlovid’s adverse effects and were unable to examine its tolerability and safety. Pesko and colleagues show a high incidence of adverse effects with 85% of patients reporting at least 1 adverse effect; 17.5% of patients discontinued the drug prematurely as opposed to 22.6% and 2.1%, respectively, in the randomized clinical trial EPIC-HR (Evaluation of Protease Inhibition for Covid-19 in High-Risk Patients) [4]. Most notably, dysgeusia was reported in 57.5% of patients compared to 5.6% in the EPIC-HR trial [4]. Although these proportions clearly outnumber the proportions in the EPIC-HR trial, the sample size in this analysis is very small and might affect the precision of the estimates." @default.
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- W4286715900 date "2022-07-23" @default.
- W4286715900 modified "2023-10-16" @default.
- W4286715900 title "Reply to Pesko et al" @default.
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- W4286715900 doi "https://doi.org/10.1093/cid/ciac589" @default.
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